BAY-593074 [Ligand Id: 10348] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL1354658 (BAY-593074) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554] | ||||||||
| ChEMBL | Displacement of [3H]CP 55940 from human CB1 receptor in cell free system | B | 7.32 | pKi | 48.3 | nM | Ki | Eur J Med Chem (2011) 46: 547-555 [PMID:21183257] |
| ChEMBL | Displacement of [3H]BAY-38-7271 from CB1 receptor in human brain cortex membranes after 90 mins by scintillation counting | B | 7.32 | pKi | 48.3 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 5999-6002 [PMID:21880487] |
| GtoPdb | - | - | 7.32 | pKi | 48.3 | nM | Ki | J Pharmacol Exp Ther (2004) 310: 620-32 [PMID:15140913] |
| CB1 receptor/Cannabinoid CB1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3571] [GtoPdb: 56] [UniProtKB: P20272] | ||||||||
| ChEMBL | Displacement of [3H]BAY-38-7271 from CB1 receptor in Wistar rat brain membranes after 90 mins by scintillation counting | B | 7.26 | pKi | 55.4 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 5999-6002 [PMID:21880487] |
| ChEMBL | Displacement of [3H]CP55940 from rat cannabinoid CB1 receptor | B | 7.26 | pKi | 55.4 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 5999-6002 [PMID:21880487] |
| GtoPdb | - | - | 7.26 | pKi | 55.4 | nM | Ki | J Pharmacol Exp Ther (2004) 310: 620-32 [PMID:15140913] |
| CB2 receptor/Cannabinoid CB2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972] | ||||||||
| GtoPdb | - | - | 7.34 | pKi | 45.5 | nM | Ki | J Pharmacol Exp Ther (2004) 310: 620-32 [PMID:15140913] |
| ChEMBL | Displacement of [3H]CP 55940 from human CB2 receptor in cell free system | B | 7.34 | pKi | 45.5 | nM | Ki | Eur J Med Chem (2011) 46: 547-555 [PMID:21183257] |
| ChEMBL | Displacement of [3H]BAY-38-7271 from recombinant human CB2 receptor expressed in CHO cells after 90 mins by scintillation counting | B | 7.34 | pKi | 45.5 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 5999-6002 [PMID:21880487] |
| ChEMBL | Displacement of [3H]CP55940 from human cannabinoid CB2 receptor | B | 7.34 | pKi | 45.5 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 5999-6002 [PMID:21880487] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
