balamapimod [Ligand Id: 9925] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2104954 (Balamapimod, MKI-833) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Raf-1 proto-oncogene, serine/threonine kinase in Human [GtoPdb: 2184] [UniProtKB: P04049] | ||||||||
| GtoPdb | Measuring c-Raf mediated activation of MEK and phosphorylation of MEK substrate. | - | 6.94 | pIC50 | 114 | nM | IC50 | US20090062281A1. 3-quinolinecarbonitrile protein kinase inhibitors (2009) |
| SRC proto-oncogene, non-receptor tyrosine kinase in Human [GtoPdb: 2206] [UniProtKB: P12931] | ||||||||
| GtoPdb | Measuring inhibition substrate phosphorylation by p60c-src tyrosine kinase in an ELISA, using an anti-phosphotyrosine detection antibody. | - | 6.55 | pIC50 | 281 | nM | IC50 | US20090062281A1. 3-quinolinecarbonitrile protein kinase inhibitors (2009) |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
