ChEMBL ligand: CHEMBL41632 (3,5,3'-triiodothyroacetate, Levothyroxine sodium impurity, triiodothyroacetic acid, or t3-acetic acid-, NSC-759294, T3-acetic acid, Tiracana, Tiratricol, TRIAC, Triiodothyroacetic acid)
Androgen receptor/Androgen Receptor in Human [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275] There should be some charts here, you may need to enable JavaScript!
Sodium/bile acid and sulphated solute cotransporter 1/Bile acid transporter in Human [ChEMBL: CHEMBL5287] [GtoPdb: 959] [UniProtKB: Q14973] There should be some charts here, you may need to enable JavaScript!
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231] There should be some charts here, you may need to enable JavaScript!
Proliferating cell nuclear antigen in Human [ChEMBL: CHEMBL2346488] [UniProtKB: P12004] There should be some charts here, you may need to enable JavaScript!
Retinoid X receptor-α/Retinoid X receptor alpha in Human [ChEMBL: CHEMBL2061] [GtoPdb: 610] [UniProtKB: P19793] There should be some charts here, you may need to enable JavaScript!
OATP1C1/Solute carrier organic anion transporter family member 1C1 in Mouse [ChEMBL: CHEMBL2073688] [GtoPdb: 1222] [UniProtKB: Q9ERB5] There should be some charts here, you may need to enable JavaScript!
Thyroid hormone receptor-α/Thyroid hormone receptor alpha in Human [ChEMBL: CHEMBL1860] [GtoPdb: 588] [UniProtKB: P10827] There should be some charts here, you may need to enable JavaScript!
Thyroid hormone receptor-β/Thyroid hormone receptor beta-1 in Human [ChEMBL: CHEMBL1947] [GtoPdb: 589] [UniProtKB: P10828] Thyroid hormone receptor-β/Thyroid hormone receptor beta-1 in Rat [ChEMBL: CHEMBL3917] [GtoPdb: 589] [UniProtKB: P18113] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Androgen receptor/Androgen Receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275]
ChEMBL	Transcriptional activity at human androgen receptor BF3 site stably transfected in eGFP-expressing human LNCAP cells after 5 days by fluorometric analysis	B	4.46	pIC50	34800	nM	IC50	J Med Chem (2011) 54: 8563-8573 [PMID:22047606]
Sodium/bile acid and sulphated solute cotransporter 1/Bile acid transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5287] [GtoPdb: 959] [UniProtKB: Q14973]
ChEMBL	Inhibition of preS1-peptide binding to human HA-tagged NTCP in U2OS expresseing NTCP in incubated for 24 hrs using Myrcludex B as substrate by competitive binding assay	B	5	pIC50	>10000	nM	IC50	J Med Chem (2022) 65: 12546-12561 [PMID:36111355]
ChEMBL	Inhibition of HA-tagged human NTCP expressed in human U2OS cells assessed as reduction in [14C]taurocholate uptake preincubated for 10 mins followed by [14C] taurocholate addition and further incubation for 10 mins by scintillation counting method	B	5.16	pIC50	6900	nM	IC50	Bioorg Med Chem Lett (2019) 29: 126623-126623 [PMID:31439379]
ChEMBL	Inhibition of human NTCP mediated TCA uptake in U2OS expresseing HA-tagged NTCP cells preincubated for 10 mins followed by substrate addition and measured after 2 mins using [3H]-taurocholate as substrate by liquid scintillation counter analysis	B	5.16	pIC50	6900	nM	IC50	J Med Chem (2022) 65: 12546-12561 [PMID:36111355]
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231]
ChEMBL	Binding affinity to recombinant PPARgamma LBD (unknown origin) by isothermal titration calorimetry	B	6.7	pKd	200	nM	Kd	J Med Chem (2020) 63: 6727-6740 [PMID:32356658]
ChEMBL	Agonist activity at recombinant human pFA-CMV fused PPARgamma expressed in HEK293T cells transfected with pFR-luciferase plasmid and pRL-SV40 plasmid incubated for 14 to 16 hrs by dual glo luciferase reporter gene assay	B	6.43	pEC50	370	nM	EC50	J Med Chem (2020) 63: 6727-6740 [PMID:32356658]
Proliferating cell nuclear antigen in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2346488] [UniProtKB: P12004]
ChEMBL	Inhibition of human recombinant PCNA interaction with PIP box protein N-5-carboxyfluorescein-SAVLQKKITDYFHPKK after 30 mins by fluorescence polarization assay	B	4.6	pIC50	25000	nM	IC50	Bioorg Med Chem (2013) 21: 1972-1977 [PMID:23395113]
Retinoid X receptor-α/Retinoid X receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2061] [GtoPdb: 610] [UniProtKB: P19793]
ChEMBL	Binding affinity to RXRalpha LBD (unknown origin) by isothermal titration calorimetry	B	5.88	pKd	1320	nM	Kd	J Med Chem (2020) 63: 6727-6740 [PMID:32356658]
ChEMBL	Agonist activity at recombinant human pFA-CMV fused RXRalpha LBD expressed in HEK293T cells transfected with pFR-luciferase plasmid and pRL-SV40 plasmid incubated for 14 to 16 hrs by dual glo luciferase reporter gene assay	B	4.92	pEC50	12000	nM	EC50	J Med Chem (2020) 63: 6727-6740 [PMID:32356658]
OATP1C1/Solute carrier organic anion transporter family member 1C1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073688] [GtoPdb: 1222] [UniProtKB: Q9ERB5]
ChEMBL	TP_TRANSPORTER: inhibition of L-T4 uptake in Oatp14-expressing HEK293 cells	F	5.67	pKi	2150	nM	Ki	Endocrinology (2004) 145: 4384-4391 [PMID:15166123]
Thyroid hormone receptor-α/Thyroid hormone receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1860] [GtoPdb: 588] [UniProtKB: P10827]
ChEMBL	Inhibition of thyroid hormone receptor alpha	B	9.85	pIC50	0.14	nM	IC50	Bioorg Med Chem (2007) 15: 4609-4617 [PMID:17467994]
ChEMBL	Concentration required to inhibit 50% of I-T3 binding to hTR1 (Thyroid hormone receptor alpha) was determined	B	9.85	pIC50	0.14	nM	IC50	J Med Chem (2003) 46: 1580-1588 [PMID:12699376]
Thyroid hormone receptor-β/Thyroid hormone receptor beta-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1947] [GtoPdb: 589] [UniProtKB: P10828]
GtoPdb	-	-	10.7	pKd	-	-	-	Mol Endocrinol (1990) 4: 227-34 [PMID:2158622]
ChEMBL	Concentration required to inhibit 50% of I-T3 binding to hTR1 (Thyroid hormone receptor beta) was determined	B	10.32	pIC50	0.05	nM	IC50	J Med Chem (2003) 46: 1580-1588 [PMID:12699376]
ChEMBL	Inhibition of human thyroid hormone receptor beta 1	B	10.32	pIC50	0.05	nM	IC50	Bioorg Med Chem (2007) 15: 5251-5261 [PMID:17524652]
ChEMBL	Inhibition of thyroid hormone receptor beta	B	10.39	pIC50	0.04	nM	IC50	Bioorg Med Chem (2007) 15: 4609-4617 [PMID:17467994]
Thyroid hormone receptor-β/Thyroid hormone receptor beta-1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3917] [GtoPdb: 589] [UniProtKB: P18113]
ChEMBL	In vitro inhibition of bound [125I]L-T3 rat plasma membrane 3,5,3'' L-triiodothyronine receptor	B	5.3	pIC50	>5000	nM	IC50	J Med Chem (1995) 38: 695-707 [PMID:7861417]
ChEMBL	In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor	B	9.82	pIC50	0.15	nM	IC50	J Med Chem (1995) 38: 695-707 [PMID:7861417]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]