BAY-X1005 [Ligand Id: 5148] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL88712 (BAY-X-005, BAY X 1005, BAY X-1005, BAY-X-1005, DG-031, Veliflapon) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 5-LOX/Arachidonate 5-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL215] [GtoPdb: 1385] [UniProtKB: P09917] | ||||||||
| ChEMBL | Inhibition of 5-LOX in human whole blood assessed as inhibition of LTB4 formation preincubated for 10 mins followed by calcium ionophore A23187 addition and measured after 30 min by RIA/RP--HPLC analysis | B | 4.94 | pIC50 | 11600 | nM | IC50 | Eur J Med Chem (2018) 153: 34-48 [PMID:28784429] |
| ChEMBL | Inhibition of 5-LOX in human PMNL cells assessed as inhibition of LTB4 formation preincubated for 5 mins followed by calcium ionophore A23187 addition and measured after 6 min by HPLC analysis | B | 6.66 | pIC50 | 220 | nM | IC50 | Eur J Med Chem (2018) 153: 34-48 [PMID:28784429] |
| ChEMBL | Inhibition of calcium ionophore (A-23187)-stimulated LTB4 formation in human neutrophil assay | F | 7.22 | pIC50 | 60 | nM | IC50 | J Med Chem (2000) 43: 690-705 [PMID:10691695] |
| histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] | ||||||||
| ChEMBL | Determination of IC50 values for inhibition of enzymatic assay of human HDAC6 with custom peptide substrate | B | 6.18 | pIC50 | 655.8 | nM | IC50 | HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activators |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
