mifepristone [Ligand Id: 2805] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1276308
  • Pregnane X receptor in Human [GtoPdb: 606] [UniProtKB: O75469]
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  • Glucocorticoid receptor in Human [GtoPdb: 625] [UniProtKB: P04150]
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  • Progesterone receptor in Human [GtoPdb: 627] [UniProtKB: P06401]
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  • Androgen receptor in Human [GtoPdb: 628] [UniProtKB: P10275]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Pregnane X receptor in Human [GtoPdb: 606] [UniProtKB: O75469]
GtoPdb - - 5 pEC50 ~10000 nM EC50 J. Clin. Invest. (1998) 102: 1016-23 [PMID:9727070]
Glucocorticoid receptor in Human [GtoPdb: 625] [UniProtKB: P04150]
GtoPdb - - 9.4 pKd - - - Eur. J. Pharmacol. (1993) 247: 145-54 [PMID:8282004];
J. Steroid Biochem. (1987) 26: 279-84 [PMID:3560943]
Progesterone receptor in Human [GtoPdb: 627] [UniProtKB: P06401]
GtoPdb - - 8.96 pKi 1.1 nM Ki Bioorg. Med. Chem. Lett. (2003) 13: 2071-4 [PMID:12781197]
GtoPdb - - 8.96 pKi 1.1 nM Ki Bioorg. Med. Chem. Lett. (2003) 13: 2071-4 [PMID:12781197]
Androgen receptor in Human [GtoPdb: 628] [UniProtKB: P10275]
GtoPdb - - 9.19 pKi 0.65 nM Ki J. Med. Chem. (2004) 47: 4213-30 [PMID:15293993]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]