harmaline [Ligand Id: 13140] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL340807 (Harmaline) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Acetylcholinesterase in Electrophorus electricus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4078] [UniProtKB: O42275] | ||||||||
| ChEMBL | Inhibition of electric eel AChE using acetylcholine iodide as substrate measured every 5 sec for 2 mins by Ellman's method | B | 5.31 | pIC50 | 4900 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 2885-2888 [PMID:22425563] |
| acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303] | ||||||||
| ChEMBL | Inhibition of human AChE by Ellman's method | B | 4.63 | pIC50 | 23700 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 2885-2888 [PMID:22425563] |
| Monoamine oxidase A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1951] [GtoPdb: 2489] [UniProtKB: P21397] | ||||||||
| GtoPdb | - | - | 7.48 | pIC50 | 32.9 | nM | IC50 | Eur J Med Chem (2021) 209: 112911 [PMID:33071056] |
| ChEMBL | Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI-TN-5B1-4 insect cells using p-tyramine as substrate preincubated for 15 mins followed by substrate addition and measured over 20 mins by horse-radish peroxidase/Amplex Red coupled fluorimetric analysis | B | 7.48 | pIC50 | 32.9 | nM | IC50 | Eur J Med Chem (2021) 209: 112911-112911 [PMID:33071056] |
| Monoamine oxidase A in Mouse [GtoPdb: 2489] [UniProtKB: Q64133] | ||||||||
| GtoPdb | Inhibition of MAOA activity in mouse brain | - | 7.92 | pIC50 | 12 | nM | IC50 | J Med Chem (1995) 38: 4786-92 [PMID:7490728] |
| Monoamine oxidase A in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3358] [UniProtKB: P21396] | ||||||||
| ChEMBL | In vitro inhibitory activity against rat brain Monoamine oxidase A | B | 7.92 | pIC50 | 12 | nM | IC50 | J Med Chem (1995) 38: 4786-4792 [PMID:7490728] |
| Monoamine oxidase B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2039] [GtoPdb: 2490] [UniProtKB: P27338] | ||||||||
| ChEMBL | Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI-TN-5B1-4 insect cells using p-tyramine as substrate preincubated for 15 mins followed by substrate addition and measured over 20 mins by horse-radish peroxidase/Amplex Red coupled fluorimetric analysis | B | 4 | pIC50 | >100000 | nM | IC50 | Eur J Med Chem (2021) 209: 112911-112911 [PMID:33071056] |
| 5-HT5A receptor/Serotonin 5a (5-HT5a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3426] [GtoPdb: 10] [UniProtKB: P47898] | ||||||||
| ChEMBL | Binding affinity towards 5-hydroxytryptamine 5A receptor using lysergic acid diethylamide (LSD) as radioligand | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2003) 46: 3930-3937 [PMID:12930153] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
