ChEMBL ligand: CHEMBL267179
FPR1/Formyl peptide receptor 1 in Human [ChEMBL: CHEMBL3359] [GtoPdb: 222] [UniProtKB: P21462] FPR1 in Mouse [GtoPdb: 222] [UniProtKB: P33766] There should be some charts here, you may need to enable JavaScript!
FPR3/Formyl peptide receptor-related sequence 1 in Mouse [ChEMBL: CHEMBL3407315] [GtoPdb: 224] [UniProtKB: O08790] There should be some charts here, you may need to enable JavaScript!
FPR2/Lipoxin A4 receptor in Human [ChEMBL: CHEMBL4227] [GtoPdb: 223] [UniProtKB: P25090] There should be some charts here, you may need to enable JavaScript!
FPR3/N-formyl peptide receptor 3 in Human [ChEMBL: CHEMBL5646] [GtoPdb: 224] [UniProtKB: P25089] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
FPR1/Formyl peptide receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3359] [GtoPdb: 222] [UniProtKB: P21462]
ChEMBL	Binding affinity to human FPR1 receptor	B	8.52	pKd	3	nM	Kd	J Med Chem (2015) 58: 1089-1099 [PMID:25587631]
ChEMBL	Displacement of [3H]-fMLP from FPR in human neutrophils	B	7.38	pKi	42	nM	Ki	Bioorg Med Chem Lett (2007) 17: 3696-3701 [PMID:17475488]
ChEMBL	Binding affinity towards fMLF receptor using human neutrophils	B	7.7	pIC50	20	nM	IC50	J Med Chem (1996) 39: 1013-1015 [PMID:8676333]
ChEMBL	Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils	F	7.7	pEC50	20	nM	EC50	J Med Chem (1996) 39: 1013-1015 [PMID:8676333]
ChEMBL	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	F	8	pEC50	10	nM	EC50	J Med Chem (2009) 52: 5044-5057 [PMID:19639995]
ChEMBL	GPCR PRESTO-Tango dose-response in agonist mode with target: FPR1	F	8.43	pEC50	3.69	nM	EC50	EUbOPEN Chemogenomics Library - GPCR Dose-Respose
GtoPdb	-	-	10.2	pEC50	-	-	-	J Exp Med (1976) 143: 1154-69 [PMID:1262785]; Biochemistry (1980) 19: 2404-10 [PMID:7387981]
FPR1 in Mouse [GtoPdb: 222] [UniProtKB: P33766]
GtoPdb	-	-	4.7	pEC50	-	-	-	J Exp Med (1999) 190: 741-7 [PMID:10477558]; J Immunol (2008) 181: 1429-37 [PMID:18606697]
FPR3/Formyl peptide receptor-related sequence 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3407315] [GtoPdb: 224] [UniProtKB: O08790]
ChEMBL	Binding affinity to mouse FPR2 receptor	B	6.52	pKd	>300	nM	Kd	J Med Chem (2015) 58: 1089-1099 [PMID:25587631]
FPR2/Lipoxin A4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4227] [GtoPdb: 223] [UniProtKB: P25090]
GtoPdb	-	-	6.37	pKd	-	-	-	J Biol Chem (1993) 268: 18167-75 [PMID:8349692]
ChEMBL	Binding affinity to human FPR2 receptor	B	6.52	pKd	>300	nM	Kd	J Med Chem (2015) 58: 1089-1099 [PMID:25587631]
ChEMBL	Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	F	4.69	pEC50	20400	nM	EC50	J Med Chem (2009) 52: 5044-5057 [PMID:19639995]
FPR3/N-formyl peptide receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5646] [GtoPdb: 224] [UniProtKB: P25089]
ChEMBL	Agonist activity at FPRL2 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	F	5.72	pEC50	1900	nM	EC50	J Med Chem (2009) 52: 5044-5057 [PMID:19639995]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]