benzatropine   Click here for help

GtoPdb Ligand ID: 7601

Synonyms: benztropine | benztropine mesylate | Cogentin®
Approved drug PDB Ligand
benzatropine is an approved drug (FDA (1954))
Compound class: Synthetic organic
Comment: Benzatropine (benztropine) is an anticholinergic drug. PubChem CID 1201549 represents an alternative isomer of this compound.
Benzatropine is reported as an inhibitor of the neutral amino acid transporter B0AT1 (SLC6A19) [1], a recently identified molecular target for treatment of type 2 diabetes and related disorders [2]. Note that the mesylate salt was used in the experiments reported in [1].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 12.47
Molecular weight 307.19
XLogP 4.28
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES CN1C2CCC1CC(C2)OC(c1ccccc1)c1ccccc1
Isomeric SMILES CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1
InChI InChI=1S/C21H25NO/c1-22-18-12-13-19(22)15-20(14-18)23-21(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18-21H,12-15H2,1H3/t18-,19+,20+
InChI Key GIJXKZJWITVLHI-PMOLBWCYSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (1954))
IUPAC Name Click here for help
(1R,5S)-3-[di(phenyl)methoxy]-8-methyl-8-azabicyclo[3.2.1]octane
International Nonproprietary Names Click here for help
INN number INN
292 benzatropine
Synonyms Click here for help
benztropine | benztropine mesylate | Cogentin®
Database Links Click here for help
CAS Registry No. 86-13-5 (source: Scifinder)
ChEBI CHEBI:3048
ChEMBL Ligand CHEMBL1201203
DrugBank Ligand DB00245
DrugCentral Ligand 333
GtoPdb PubChem SID 223365936
PubChem CID 1201549
RCSB PDB Ligand CXQ
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Wikipedia Benzatropine