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Synonyms: benztropine | benztropine mesylate | Cogentin®
benzatropine is an approved drug (FDA (1954))
Compound class: Synthetic organic
Comment: Benzatropine (benztropine) is an anticholinergic drug. PubChem CID 1201549 represents an alternative isomer of this compound.
Benzatropine is reported as an inhibitor of the neutral amino acid transporter B0AT1 (SLC6A19) , a recently identified molecular target for treatment of type 2 diabetes and related disorders . Note that the mesylate salt was used in the experiments reported in .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|No information available.|
|Summary of Clinical Use|
|Used in the symptomatic treatment of Parkinson's disease. May also be used to treat extrapyramidal symptoms, such as dystonia and Parkinsonism, which can be side effects of some antipsychotic drugs such as chlorpromazine, fluphenazine and perphenazine.|
|Mechanism Of Action and Pharmacodynamic Effects|
|Benzatropine is a centrally acting antagonist of muscarinic acetylcholine receptors. In addition, benzatropine inhibits the reuptake of dopamine at nerve terminals via the dopamine transporter (SLC6A3). Dopamine-acetylcholine imbalance caused by a decrease in dopaminergic activity, is believed to be responsible for the symptoms of Parkinson's disease and extrapyramidal reactions. The dual effect of benzatropine is believed to restore the balance between these neurotransmitters.|
For extended ADME data see the following: