ChEMBL ligand: CHEMBL201945
δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] There should be some charts here, you may need to enable JavaScript!
NOP receptor/Nociceptin receptor in Human [ChEMBL: CHEMBL2014] [GtoPdb: 320] [UniProtKB: P41146] NOP receptor/Nociceptin receptor in Mouse [ChEMBL: CHEMBL3621] [GtoPdb: 320] [UniProtKB: P35377] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL	Displacement of [3H]naltrindole from cloned human delta opioid receptor expressed in CHO cells	B	5	pIC50	>10000	nM	IC50	J Med Chem (2006) 49: 847-849 [PMID:16451050]
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL	Displacement of [3H]U-69593 from cloned human kappa opioid receptor expressed in CHO cells	B	5.6	pIC50	2500	nM	IC50	J Med Chem (2006) 49: 847-849 [PMID:16451050]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL	Displacement of [3H]diprenorphin from cloned human mu opioid receptor expressed in CHO cells	B	5.17	pIC50	6700	nM	IC50	J Med Chem (2006) 49: 847-849 [PMID:16451050]
NOP receptor/Nociceptin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2014] [GtoPdb: 320] [UniProtKB: P41146]
ChEMBL	Displacement of [3H]N/OFQ from human recombinant NOP receptor expressed in CHO cells	B	9.62	pKi	0.24	nM	Ki	Bioorg Med Chem (2009) 17: 5080-5095 [PMID:19527931]
GtoPdb	-	-	9.62	pKi	0.24	nM	Ki	Eur J Pharmacol (2009) 614: 50-7 [PMID:19445927]
ChEMBL	Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells	B	9.57	pIC50	0.27	nM	IC50	J Med Chem (2006) 49: 847-849 [PMID:16451050]
ChEMBL	Antagonist activity on nociceptin-induced [35S]GTP-gamma-S binding to ORL1 expressed in CHO cells	F	9.82	pIC50	0.15	nM	IC50	J Med Chem (2006) 49: 847-849 [PMID:16451050]
GtoPdb	-	-	10	pIC50	0.1	nM	IC50	Eur J Pharmacol (2009) 614: 50-7 [PMID:19445927]; J Med Chem (2006) 49: 847-9 [PMID:16451050]
ChEMBL	Agonist activity on nociceptin-induced maximal [35S]GTP-gamma-S binding to ORL1 expressed in CHO cells	F	6	pEC50	>1000	nM	EC50	J Med Chem (2006) 49: 847-849 [PMID:16451050]
NOP receptor/Nociceptin receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3621] [GtoPdb: 320] [UniProtKB: P35377]
ChEMBL	Antagonist activity at nociceptin receptor in Swiss mouse vas deferens assessed as inhibition of electrically evoked twitches	F	8.24	pKd	5.75	nM	Kd	Bioorg Med Chem (2009) 17: 5080-5095 [PMID:19527931]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]