nitrofurantoin [Ligand Id: 10917] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL572 (Berkfurin, Ceduran, Dantafur, Furadantin, Furalan, Genfura, Ivadantin, Macrobid, Macrodantin, Nitrofurantoin, Nitrofurantoin anhydrous, Nitrofurantoin macrocrystal, Nitrofurantoin macrocrystalline, Nitrofurantoin, macrocrystalline, Nitrofurantoin, macrocrystals, Nitrofurantoin (monohydrate/macrocrystals), Nitrofurantoinum anhydrous, NSC-2107, NSC-44150)
  • CDGSH iron-sulfur domain-containing protein 1 in Human [ChEMBL: CHEMBL1795168] [UniProtKB: Q9NZ45]
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  • mitochondrial pyruvate carrier 2 in Human [GtoPdb: 3023] [UniProtKB: O95563]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CDGSH iron-sulfur domain-containing protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795168] [UniProtKB: Q9NZ45]
ChEMBL Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichia coli BL21 by Cheng-Prusoff analysis B 6.09 pKi 816 nM Ki Bioorg Med Chem Lett (2016) 26: 5350-5353 [PMID:27687671]
ChEMBL Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichia coli BL21 by scintillation proximity assay B 4.72 pIC50 19100 nM IC50 Bioorg Med Chem Lett (2016) 26: 5350-5353 [PMID:27687671]
GroEL/GroES in Escherichia coli (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4106139] [UniProtKB: Q548M1, Q7BGE6]
ChEMBL Inhibition of Escherichia coli GroEL/ES-mediated refolding of the denatured malate dehydrogenase B 4 pIC50 >100000 nM IC50 Bioorg Med Chem (2020) 28: 115710-115710 [PMID:33007545]
ChEMBL Inhibition of Escherichia coli GroEL/ES-mediated refolding of the denatured malate dehydrogenase in presence of Escherichia coli type 1 NfsB nitroreductase B 4.08 pIC50 84000 nM IC50 Bioorg Med Chem (2020) 28: 115710-115710 [PMID:33007545]
ChEMBL Inhibition of Escherichia coli GroEL/ES assessed as inhibition of native malate dehydrogenase treated after denatured malate dehydrogenase completely refold B 4.2 pIC50 >63000 nM IC50 Bioorg Med Chem (2020) 28: 115710-115710 [PMID:33007545]
ChEMBL Inhibition of Escherichia coli GroEL/ES assessed as inhibition of native malate dehydrogenase treated after denatured malate dehydrogenase completely refold in presence of NfsB nitroreductase B 4.25 pIC50 >56000 nM IC50 Bioorg Med Chem (2020) 28: 115710-115710 [PMID:33007545]
mitochondrial pyruvate carrier 2 in Human [GtoPdb: 3023] [UniProtKB: O95563]
GtoPdb - - 5.48 pIC50 3300 nM IC50 Mol Metab (2022) 60: 101469 [PMID:35278701]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]