Synonyms: PBTZ169
Compound class:
Synthetic organic
Comment: Macozinone (PBTZ169) is the lead from a series of piperazine-containing benzothiazinones [1]. It has potent antimycobacterial activity and is under clinical evaluation as a treatment for tuberculosis (TB). Macozinone is an inhibitor of decaprenylphosphoryl-beta-D-ribose oxidase (DprE1), an essential mycobacterial cell wall biosynthesis enzyme [1].
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Classification | |
Compound class | Synthetic organic |
IUPAC Name |
2-[4-(cyclohexylmethyl)piperazin-1-yl]-8-nitro-6-(trifluoromethyl)-1,3-benzothiazin-4-one |
International Nonproprietary Names | |
INN number | INN |
10732 | macozinone |
Synonyms |
PBTZ169 |
Database Links | |
BindingDB Ligand | 50515570 |
CAS Registry No. | 1377239-83-2 (source: Scifinder) |
ChEMBL Ligand | CHEMBL3330226 |
DrugBank Ligand | DB14821 |
GtoPdb PubChem SID | 491299837 |
PubChem CID | 57331386 |
Search Google for chemical match using the InChIKey | BJDZBXGJNBMCAV-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | BJDZBXGJNBMCAV |
Search PubMed clinical trials | macozinone |
Search PubMed titles | macozinone |
Search PubMed titles/abstracts | macozinone |
UniChem Compound Search for chemical match using the InChIKey | BJDZBXGJNBMCAV-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | BJDZBXGJNBMCAV-UHFFFAOYSA-N |