ChEMBL ligand: CHEMBL6437 (J16.389I, Mianserin, Mianserina, Mianserine, Tolvon)
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348] Alpha-1a adrenergic receptor in Bovine [ChEMBL: CHEMBL4892] [UniProtKB: P18130] α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140] There should be some charts here, you may need to enable JavaScript!
α1B-adrenoceptor in Human [GtoPdb: 23] [UniProtKB: P35368] α1B-adrenoceptor/Alpha-1b adrenergic receptor in Rat [ChEMBL: CHEMBL315] [GtoPdb: 23] [UniProtKB: P15823] There should be some charts here, you may need to enable JavaScript!
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100] There should be some charts here, you may need to enable JavaScript!
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913] Alpha-2a adrenergic receptor in Bovine [ChEMBL: CHEMBL4744] [UniProtKB: Q28838] There should be some charts here, you may need to enable JavaScript!
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089] There should be some charts here, you may need to enable JavaScript!
α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825] There should be some charts here, you may need to enable JavaScript!
D1 receptor/Dopamine D1 receptor in Human [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728] D1 receptor/Dopamine D1 receptor in Rat [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901] There should be some charts here, you may need to enable JavaScript!
D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] D2 receptor/Dopamine D2 receptor in Rat [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] There should be some charts here, you may need to enable JavaScript!
D3 receptor/Dopamine D3 receptor in Human [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462] D3 receptor/Dopamine D3 receptor in Rat [ChEMBL: CHEMBL3138] [GtoPdb: 216] [UniProtKB: P19020] There should be some charts here, you may need to enable JavaScript!
D4 receptor/Dopamine D4 receptor in Human [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917] There should be some charts here, you may need to enable JavaScript!
DAT/Dopamine transporter in Rat [ChEMBL: CHEMBL338] [GtoPdb: 927] [UniProtKB: P23977] There should be some charts here, you may need to enable JavaScript!
G-protein coupled receptor in Honeybee [ChEMBL: CHEMBL2366519] [UniProtKB: Q9NG02] There should be some charts here, you may need to enable JavaScript!
H1 receptor/Histamine H1 receptor in Human [ChEMBL: CHEMBL231] [GtoPdb: 262] [UniProtKB: P35367] Histamine H1 receptor in Guinea pig [ChEMBL: CHEMBL3943] [UniProtKB: P31389] There should be some charts here, you may need to enable JavaScript!
H2 receptor/Histamine H2 receptor in Human [ChEMBL: CHEMBL1941] [GtoPdb: 263] [UniProtKB: P25021] Histamine H2 receptor in Guinea pig [ChEMBL: CHEMBL2882] [UniProtKB: P47747] There should be some charts here, you may need to enable JavaScript!
M1 receptor/Muscarinic acetylcholine receptor M1 in Human [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229] There should be some charts here, you may need to enable JavaScript!
M2 receptor/Muscarinic acetylcholine receptor M2 in Human [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172] There should be some charts here, you may need to enable JavaScript!
M3 receptor/Muscarinic acetylcholine receptor M3 in Human [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309] There should be some charts here, you may need to enable JavaScript!
M4 receptor/Muscarinic acetylcholine receptor M4 in Human [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173] There should be some charts here, you may need to enable JavaScript!
M5 receptor/Muscarinic acetylcholine receptor M5 in Human [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912] M5 receptor/Muscarinic acetylcholine receptor M5 in Rat [ChEMBL: CHEMBL277] [GtoPdb: 17] [UniProtKB: P08911] There should be some charts here, you may need to enable JavaScript!
NET/Norepinephrine transporter in Human [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975] Norepinephrine transporter in Rat [ChEMBL: CHEMBL304] [UniProtKB: Q9WTR4] There should be some charts here, you may need to enable JavaScript!
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327] There should be some charts here, you may need to enable JavaScript!
5-HT1B receptor in Mouse [GtoPdb: 2] [UniProtKB: P28334] 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564] There should be some charts here, you may need to enable JavaScript!
5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221] There should be some charts here, you may need to enable JavaScript!
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842] There should be some charts here, you may need to enable JavaScript!
5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595] 5-HT2B receptor in Rat [GtoPdb: 7] [UniProtKB: P30994] There should be some charts here, you may need to enable JavaScript!
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Rat [ChEMBL: CHEMBL324] [GtoPdb: 8] [UniProtKB: P08909] There should be some charts here, you may need to enable JavaScript!
5-HT3E/5-HT3B/5-HT3A/5-HT3D/5-HT3C/Serotonin 3 (5-HT3) receptor in Human [ChEMBL: CHEMBL2094132] [GtoPdb: 377, 374, 373, 376, 375] [UniProtKB: A5X5Y0, O95264, P46098, Q70Z44, Q8WXA8] 5-HT3A/5-HT3B/Serotonin 3 (5-HT3) receptor in Rat [ChEMBL: CHEMBL2094116] [GtoPdb: 373, 374] [UniProtKB: P35563, Q9JJ16] There should be some charts here, you may need to enable JavaScript!
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406] 5-HT6 receptor in Rat [GtoPdb: 11] [UniProtKB: P31388] There should be some charts here, you may need to enable JavaScript!
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969] 5-HT7 receptor in Mouse [GtoPdb: 12] [UniProtKB: P32304] 5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Rat [ChEMBL: CHEMBL3223] [GtoPdb: 12] [UniProtKB: P32305] There should be some charts here, you may need to enable JavaScript!
SERT/Serotonin transporter in Human [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645] SERT/Serotonin transporter in Rat [ChEMBL: CHEMBL313] [GtoPdb: 928] [UniProtKB: P31652] There should be some charts here, you may need to enable JavaScript!
LPA1 receptor in Human [GtoPdb: 272] [UniProtKB: Q92633] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348]
ChEMBL	Inhibition of specific [3H]prazosin binding (0.2 nM) to rat brain membranes alpha-1 adrenergic receptor	F	6.6	pKd	251.19	nM	Kd	J Med Chem (1984) 27: 495-503 [PMID:6142954]
GtoPdb	-	-	7.6	pKi	-	-	-	Jpn J Pharmacol (2001) 86: 189-95 [PMID:11459121]
ChEMBL	Binding affinity for human cloned Alpha-1A adrenergic receptor	B	6.39	pIC50	407.38	nM	IC50	Bioorg Med Chem Lett (2002) 12: 243-248 [PMID:11755364]
ChEMBL	Binding affinity for human cloned Alpha-1A adrenergic receptor	B	6.39	pIC50	407.38	nM	IC50	Bioorg Med Chem Lett (2002) 12: 249-253 [PMID:11755365]
Alpha-1a adrenergic receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4892] [UniProtKB: P18130]
ChEMBL	Displacement of [3H]prazosin from calf cerebral cortex alpha-1 adrenergic receptor	B	7.37	pKi	43	nM	Ki	J Med Chem (1984) 27: 1182-1185 [PMID:6088770]
ChEMBL	Binding activity against alpha-1 adrenergic receptor from calf cerebral cortex, using [3H]-prazosin as the radioligand	B	7.37	pKi	43	nM	Ki	J Med Chem (1983) 26: 1696-1701 [PMID:6139479]
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140]
ChEMBL	DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)	B	7.04	pKi	91	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)	B	6.65	pIC50	224	nM	IC50	DrugMatrix in vitro pharmacology data
ChEMBL	Compound was tested for its inhibitory activity against Alpha-1 adrenergic receptor	B	10.15	pIC50	0.07	nM	IC50	J Med Chem (1999) 42: 3154-3162 [PMID:10447960]
α1B-adrenoceptor in Human [GtoPdb: 23] [UniProtKB: P35368]
GtoPdb	-	-	7.4	pKi	-	-	-	Jpn J Pharmacol (2001) 86: 189-95 [PMID:11459121]
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL315] [GtoPdb: 23] [UniProtKB: P15823]
ChEMBL	DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)	B	7.18	pKi	66	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)	B	6.92	pIC50	119	nM	IC50	DrugMatrix in vitro pharmacology data
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100]
ChEMBL	DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)	B	7.39	pKi	41	nM	Ki	DrugMatrix in vitro pharmacology data
GtoPdb	-	-	7.5	pKi	-	-	-	Jpn J Pharmacol (2001) 86: 189-95 [PMID:11459121]
ChEMBL	DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)	B	7.08	pIC50	83	nM	IC50	DrugMatrix in vitro pharmacology data
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
ChEMBL	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	B	7.8	pKi	16	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	B	8.32	pKi	4.8	nM	Ki	J Med Chem (2005) 48: 1709-1712 [PMID:15771415]
ChEMBL	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	B	7.37	pIC50	43	nM	IC50	DrugMatrix in vitro pharmacology data
ChEMBL	Binding affinity for human cloned Alpha-2A adrenergic receptor	B	7.68	pIC50	20.89	nM	IC50	Bioorg Med Chem Lett (2002) 12: 243-248 [PMID:11755364]
Alpha-2a adrenergic receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4744] [UniProtKB: Q28838]
ChEMBL	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	B	7.77	pKi	17	nM	Ki	J Med Chem (1983) 26: 1696-1701 [PMID:6139479]
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
ChEMBL	DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)	B	7.62	pKi	24	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)	B	7.28	pIC50	52	nM	IC50	DrugMatrix in vitro pharmacology data
α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825]
ChEMBL	DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)	B	7.59	pKi	26	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	Inhibition of [3H]rauwolscine binding to Alpha-2C adrenergic receptor	B	8.42	pKi	3.8	nM	Ki	J Med Chem (2005) 48: 1709-1712 [PMID:15771415]
ChEMBL	DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)	B	6.75	pIC50	179	nM	IC50	DrugMatrix in vitro pharmacology data
ChEMBL	Binding affinity for human cloned Alpha-2C adrenergic receptor	B	7.37	pIC50	42.66	nM	IC50	Bioorg Med Chem Lett (2002) 12: 243-248 [PMID:11755364]
ChEMBL	Binding affinity for human cloned Alpha-2C adrenergic receptor	B	7.37	pIC50	42.66	nM	IC50	Bioorg Med Chem Lett (2002) 12: 249-253 [PMID:11755365]
D1 receptor/Dopamine D1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728]
ChEMBL	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	B	6.57	pKi	271	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	B	6.27	pIC50	543	nM	IC50	DrugMatrix in vitro pharmacology data
D1 receptor/Dopamine D1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901]
ChEMBL	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	B	5.85	pKi	1420	nM	Ki	J Med Chem (2005) 48: 1709-1712 [PMID:15771415]
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL	Inhibition of [3H]-spiperone binding to human Dopamine receptor D2	B	5.66	pKi	2197	nM	Ki	J Med Chem (2005) 48: 1709-1712 [PMID:15771415]
ChEMBL	Binding affinity for human cloned Dopamine receptor D2L	B	5.15	pIC50	7079.46	nM	IC50	Bioorg Med Chem Lett (2002) 12: 243-248 [PMID:11755364]
ChEMBL	Binding affinity for human cloned Dopamine receptor D2L	B	5.15	pIC50	7079.46	nM	IC50	Bioorg Med Chem Lett (2002) 12: 249-253 [PMID:11755365]
D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
ChEMBL	The binding affinity at the Dopamine receptor D2 determined using [3H]spiperone	B	6	pKi	1000	nM	Ki	J Med Chem (2002) 45: 3280-3285 [PMID:12109911]
ChEMBL	Binding affinity towards Dopamine receptor D2 at 1.0 uM concentration	B	6.08	pKi	828	nM	Ki	J Med Chem (1987) 30: 1433-1454 [PMID:3039136]
ChEMBL	Binding affinity for rat Dopamine receptor D2	B	5.45	pIC50	3548.13	nM	IC50	Bioorg Med Chem Lett (2002) 12: 243-248 [PMID:11755364]
ChEMBL	Binding affinity for rat Dopamine receptor D2	B	5.45	pIC50	3548.13	nM	IC50	Bioorg Med Chem Lett (2002) 12: 249-253 [PMID:11755365]
D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
ChEMBL	Inhibition of [125I]iodosulpiride binding to human Dopamine receptor D3	B	5.55	pKi	2841	nM	Ki	J Med Chem (2005) 48: 1709-1712 [PMID:15771415]
ChEMBL	Binding affinity for human cloned Dopamine receptor D3	B	5.41	pIC50	3890.45	nM	IC50	Bioorg Med Chem Lett (2002) 12: 243-248 [PMID:11755364]
ChEMBL	Binding affinity for human cloned Dopamine receptor D3	B	5.41	pIC50	3890.45	nM	IC50	Bioorg Med Chem Lett (2002) 12: 249-253 [PMID:11755365]
D3 receptor/Dopamine D3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3138] [GtoPdb: 216] [UniProtKB: P19020]
ChEMBL	Tested for binding affinity against dopamine receptor D3 expressed in Sf9 cells.	B	5.82	pKi	1524	nM	Ki	J Med Chem (1993) 36: 1499-1500 [PMID:8098771]
D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
ChEMBL	Binding affinity for human cloned Dopamine receptor D4	B	5.48	pIC50	3311.31	nM	IC50	Bioorg Med Chem Lett (2002) 12: 243-248 [PMID:11755364]
ChEMBL	Binding affinity for human cloned Dopamine receptor D4	B	5.48	pIC50	3311.31	nM	IC50	Bioorg Med Chem Lett (2002) 12: 249-253 [PMID:11755365]
DAT/Dopamine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL338] [GtoPdb: 927] [UniProtKB: P23977]
ChEMBL	Inhibition of dopamine (DA) uptake into rat brain synaptosomes	F	5	pKi	>10000	nM	Ki	J Med Chem (1984) 27: 943-946 [PMID:6747993]
ChEMBL	Inhibition of the uptake of tritiated dopamine (DA) in rat synaptosomes	B	5	pKi	>10000	nM	Ki	J Med Chem (1987) 30: 1433-1454 [PMID:3039136]
G-protein coupled receptor in Honeybee (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366519] [UniProtKB: Q9NG02]
ChEMBL	Antagonist activity at Apis mellifera tyramine receptor TyR1	B	4.14	pIC50	73000	nM	IC50	Pest Manag Sci (2013) 69: 126-134 [PMID:23129510]
H1 receptor/Histamine H1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL231] [GtoPdb: 262] [UniProtKB: P35367]
ChEMBL	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	B	8.77	pKi	1.7	nM	Ki	J Med Chem (2005) 48: 1709-1712 [PMID:15771415]
ChEMBL	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	B	9.76	pKi	0.17	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	Binding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligand	B	8.47	pIC50	3.39	nM	IC50	Bioorg Med Chem Lett (2002) 12: 243-248 [PMID:11755364]
ChEMBL	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	B	8.82	pIC50	1.51	nM	IC50	DrugMatrix in vitro pharmacology data
Histamine H1 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3943] [UniProtKB: P31389]
ChEMBL	Inhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 min	B	9.07	pKi	0.85	nM	Ki	J Med Chem (1995) 38: 3351-3360 [PMID:7650688]
H2 receptor/Histamine H2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1941] [GtoPdb: 263] [UniProtKB: P25021]
ChEMBL	DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine)	B	6	pKi	992	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine)	B	6	pIC50	1008	nM	IC50	DrugMatrix in vitro pharmacology data
Histamine H2 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2882] [UniProtKB: P47747]
ChEMBL	Inhibitory activity against brain adenylate cyclase Histamine H2 receptor	F	6.06	pIC50	880	nM	IC50	J Med Chem (1999) 42: 3154-3162 [PMID:10447960]
M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
ChEMBL	DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)	B	6.46	pKi	343	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)	B	5.85	pIC50	1423	nM	IC50	DrugMatrix in vitro pharmacology data
M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
ChEMBL	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	B	6.42	pKi	383	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	B	5.97	pIC50	1078	nM	IC50	DrugMatrix in vitro pharmacology data
M3 receptor/Muscarinic acetylcholine receptor M3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309]
ChEMBL	DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)	B	6.53	pKi	298	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)	B	5.85	pIC50	1405	nM	IC50	DrugMatrix in vitro pharmacology data
M4 receptor/Muscarinic acetylcholine receptor M4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173]
ChEMBL	DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)	B	6.54	pKi	288	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)	B	5.68	pIC50	2066	nM	IC50	DrugMatrix in vitro pharmacology data
M5 receptor/Muscarinic acetylcholine receptor M5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912]
ChEMBL	DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)	B	6.64	pKi	230	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)	B	6.49	pIC50	320	nM	IC50	DrugMatrix in vitro pharmacology data
M5 receptor/Muscarinic acetylcholine receptor M5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL277] [GtoPdb: 17] [UniProtKB: P08911]
ChEMBL	Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellum	B	5.72	pIC50	1900	nM	IC50	J Med Chem (1984) 27: 995-1003 [PMID:6747997]
NET/Norepinephrine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975]
ChEMBL	DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55)	B	6.79	pKi	161	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55)	B	6.79	pIC50	163	nM	IC50	DrugMatrix in vitro pharmacology data
Norepinephrine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL304] [UniProtKB: Q9WTR4]
ChEMBL	Inhibition of [3H]nisoxetine binding to rat Norepinephrine transporter	B	7	pKi	101	nM	Ki	J Med Chem (2005) 48: 1709-1712 [PMID:15771415]
ChEMBL	Inhibition of norepinephrine (NE) into rat brain synaptosomes	F	7.59	pKi	26	nM	Ki	J Med Chem (1984) 27: 943-946 [PMID:6747993]
ChEMBL	Inhibition of uptake of tritiated norepinephrine (NE) in rat synaptosomes	B	7.59	pKi	26	nM	Ki	J Med Chem (1987) 30: 1433-1454 [PMID:3039136]
ChEMBL	The binding affinity at the Norepinephrine transporter reuptake sites determined using competition binding assay	B	7.66	pIC50	22	nM	IC50	J Med Chem (2002) 45: 3280-3285 [PMID:12109911]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL	Binding affinity to 5HT1A receptor	B	6.4	pKd	398.11	nM	Kd	J Med Chem (2009) 52: 6107-6125 [PMID:19754201]
ChEMBL	The binding affinity at the 5-hydroxytryptamine 1A receptor determined using [3H]5-CT	B	6.3	pKi	>500	nM	Ki	J Med Chem (2002) 45: 3280-3285 [PMID:12109911]
ChEMBL	Binding affinity for human cloned 5-hydroxytryptamine 1A receptor	B	6.4	pIC50	398.11	nM	IC50	Bioorg Med Chem Lett (2002) 12: 243-248 [PMID:11755364]
ChEMBL	Binding affinity for human cloned 5-hydroxytryptamine 1A receptor	B	6.4	pIC50	398.11	nM	IC50	Bioorg Med Chem Lett (2002) 12: 249-253 [PMID:11755365]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
ChEMBL	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT)	B	6.3	pKi	498	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT)	B	6.06	pIC50	872	nM	IC50	DrugMatrix in vitro pharmacology data
5-HT1B receptor in Mouse [GtoPdb: 2] [UniProtKB: P28334]
GtoPdb	-	-	8.3	pKi	-	-	-	Proc Natl Acad Sci USA (1992) 89: 3020-4 [PMID:1557407]
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564]
ChEMBL	Binding affinity (Ki) to rat cortical membranes at 5-HT1B binding site by using [125 I] ICYP as a radioligand.	B	5.33	pKi	4700	nM	Ki	J Med Chem (1987) 30: 1-12 [PMID:3543362]
5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
ChEMBL	Binding affinity for human cloned 5-hydroxytryptamine 1D receptor	B	6.42	pIC50	380.19	nM	IC50	Bioorg Med Chem Lett (2002) 12: 243-248 [PMID:11755364]
ChEMBL	Binding affinity for human cloned 5-hydroxytryptamine 1D receptor	B	6.42	pIC50	380.19	nM	IC50	Bioorg Med Chem Lett (2002) 12: 249-253 [PMID:11755365]
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
ChEMBL	Displacement of [3H]ketanserin from human 5HT2A receptor expressed in tsA201 cell membranes after 1 hr by scintillation counting analysis	B	7.57	pKi	27	nM	Ki	J Med Chem (2013) 56: 1211-1227 [PMID:23301527]
ChEMBL	Displacement of [3H]ketanserin from human 5HT2A receptor expressed in tsA201 cell membranes after 1 hr by scintillation counting analysis	B	7.57	pKi	26.92	nM	Ki	J Med Chem (2013) 56: 1211-1227 [PMID:23301527]
ChEMBL	Antagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular calcium release measured for 90 secs by fluorescence assay	F	8.09	pKi	8.13	nM	Ki	J Med Chem (2013) 56: 1211-1227 [PMID:23301527]
ChEMBL	Antagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular calcium release measured for 90 secs by fluorescence assay	F	8.09	pKi	8.1	nM	Ki	J Med Chem (2013) 56: 1211-1227 [PMID:23301527]
ChEMBL	Inhibition of [125I]R91150 binding to human 5-hydroxytryptamine 2A receptor	B	8.37	pKi	4.3	nM	Ki	J Med Chem (2005) 48: 1709-1712 [PMID:15771415]
ChEMBL	Displacement of [3H]ketanserin from recombinant human 5-HT2A receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting method	B	8.49	pKi	3.2	nM	Ki	Bioorg Med Chem Lett (2018) 28: 2039-2049 [PMID:29730027]
ChEMBL	Displacement of [3H]-ketanserin from recombinant human 5HT2A receptor expressed in HEK293 cells measured after 1.5 hrs by microbeta scintillation counting analysis	B	8.55	pKi	2.8	nM	Ki	Eur J Med Chem (2019) 166: 144-158 [PMID:30703658]
ChEMBL	Displacement of [3H]ketanserin from human 5HT2A receptor expressed in HEK293 cells incubated for 1.5 hrs by Cheng-Prusoff analysis based microbeta scintillation counting method	B	8.55	pKi	2.8	nM	Ki	Eur J Med Chem (2019) 180: 383-397 [PMID:31325785]
ChEMBL	Displacement of [3H]-ketanserin from human 5-HT2A receptor expressed in CHO-K1 cell membranes after 60 mins by scintillation counting method	B	8.66	pKi	2.2	nM	Ki	Eur J Med Chem (2017) 137: 108-116 [PMID:28575721]
ChEMBL	Displacement of [3H]-ketanserin from human 5-HT2A receptor expressed in CHO-K1 cell membranes after 60 mins by microbeta scintillation counting analysis	B	8.7	pKi	2	nM	Ki	Bioorg Med Chem (2018) 26: 527-535 [PMID:29269256]
ChEMBL	Displacement of [3H]-ketanserin from recombinant human 5HT2A receptor expressed in CHOK1 cell membranes measured after 1 hr by microbeta counting method	B	8.72	pKi	1.91	nM	Ki	Eur J Med Chem (2020) 191: 112149-112149 [PMID:32105980]
ChEMBL	Displacement of [3H]-ketanserin from human 5-HT2A receptor expressed in CHOK1 cell membranes after 60 mins by microbeta scintillation counting method	B	8.92	pKi	1.2	nM	Ki	Medchemcomm (2017) 8: 1690-1696 [PMID:30108880]
ChEMBL	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)	B	9.3	pKi	0.5	nM	Ki	DrugMatrix in vitro pharmacology data
GtoPdb	-	-	9.6	pKi	-	-	-	Synapse (2000) 35: 79-95 [PMID:10611634]; Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733]; Cardiovasc Drugs Ther (2003) 17: 427-34 [PMID:15107597]
ChEMBL	Binding affinity for human cloned Alpha-2A adrenergic receptor	B	7.68	pIC50	20.89	nM	IC50	Bioorg Med Chem Lett (2002) 12: 249-253 [PMID:11755365]
ChEMBL	Binding affinity for human cloned 5-hydroxytryptamine 2A receptor expressed in L929 cells using [125I]R91150 as radioligand	B	7.98	pIC50	10.47	nM	IC50	Bioorg Med Chem Lett (2002) 12: 243-248 [PMID:11755364]
ChEMBL	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)	B	8.75	pIC50	1.76	nM	IC50	DrugMatrix in vitro pharmacology data
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842]
ChEMBL	Displacement of [3H]-ketanserin from rat cerebral cortex 5HT2A receptor measured after 20 mins by liquid scintillation counter method	B	7.74	pKi	18.4	nM	Ki	Bioorg Med Chem (2016) 24: 3994-4007 [PMID:27377863]
ChEMBL	Displacement of [3H]ketanserin from 5HT2A in rat brain cerebral cortex after 20 mins by scintillation counting	B	8.3	pKi	5	nM	Ki	Eur J Med Chem (2011) 46: 4474-4488 [PMID:21816515]
ChEMBL	Displacement of [3H]Ketanserin from 5HT2A receptor in Rattus norvegicus (rat) cerebral cortex by filter binding assay	B	8.46	pKi	3.5	nM	Ki	Med Chem Res (2008) 17: 507-514
ChEMBL	Displacement of [3H]ketanserin (0.5 nM) from rat cerebral cortex 5-hydroxytryptamine 2A receptors	B	8.6	pKi	2.5	nM	Ki	J Med Chem (2003) 46: 265-283 [PMID:12519065]
ChEMBL	The binding affinity at 5-hydroxytryptamine 2A receptor was determined using [3H]ketanserin	B	8.82	pKi	1.5	nM	Ki	J Med Chem (2002) 45: 3280-3285 [PMID:12109911]
GtoPdb	-	-	9	pKi	-	-	-	J Pharmacol Exp Ther (1998) 286: 85-90 [PMID:9655845]; Psychopharmacology (Berl) (1996) 126: 234-40 [PMID:8876023]
5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595]
ChEMBL	Displacement of [3H]-5HT from human 5-HT2B receptor expressed in african green monkey COS7 cells assessed as inhibition constant	B	8.05	pKi	9	nM	Ki	J Med Chem (2023) 66: 11027-11039 [PMID:37584406]
ChEMBL	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	B	8.33	pKi	4.64	nM	Ki	DrugMatrix in vitro pharmacology data
GtoPdb	-	-	8.8	pKi	-	-	-	Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733]; Naunyn Schmiedebergs Arch Pharmacol (1998) 357: 17-24 [PMID:9459568]; Br J Pharmacol (1999) 127: 1075-82 [PMID:10455251]
ChEMBL	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	B	8.14	pIC50	7.29	nM	IC50	DrugMatrix in vitro pharmacology data
5-HT2B receptor in Rat [GtoPdb: 7] [UniProtKB: P30994]
GtoPdb	-	-	7.3	pKi	-	-	-	Mol Pharmacol (1993) 43: 419-26 [PMID:8450835]
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
ChEMBL	Evaluated for the binding affinity to porcine choroid plexus at 5-hydroxytryptamine 2C receptor binding site by using [3H]-MES as a radioligand.	B	8	pKi	10	nM	Ki	J Med Chem (1987) 30: 1-12 [PMID:3543362]
ChEMBL	Antagonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular calcium release measured for 90 secs by fluorescence assay	F	8.09	pKi	8.13	nM	Ki	J Med Chem (2013) 56: 1211-1227 [PMID:23301527]
ChEMBL	Antagonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular calcium release measured for 90 secs by fluorescence assay	F	8.1	pKi	8	nM	Ki	J Med Chem (2013) 56: 1211-1227 [PMID:23301527]
ChEMBL	Inhibition of [3H]mesulergine binding to human 5-hydroxytryptamine 2C receptor	B	8.36	pKi	4.4	nM	Ki	J Med Chem (2005) 48: 1709-1712 [PMID:15771415]
ChEMBL	Binding affinity of compound towards 5-hydroxytryptamine 1C receptor using [3H]mesulergine (1.2 nM) ligand in choroid Plexus pig was determined	B	8.42	pKi	3.8	nM	Ki	J Med Chem (1997) 40: 952-960 [PMID:9083484]
ChEMBL	Displacement of [3H]mesulergine from human 5HT2C receptor expressed in tsA201 cell membranes after 1 hr by scintillation counting analysis	B	8.76	pKi	1.74	nM	Ki	J Med Chem (2013) 56: 1211-1227 [PMID:23301527]
ChEMBL	Displacement of [3H]mesulergine from human 5HT2C receptor expressed in tsA201 cell membranes after 1 hr by scintillation counting analysis	B	8.77	pKi	1.7	nM	Ki	J Med Chem (2013) 56: 1211-1227 [PMID:23301527]
GtoPdb	-	-	9.2	pKi	-	-	-	Synapse (2000) 35: 79-95 [PMID:10611634]; Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733]; J Neurochem (1999) 72: 2127-34 [PMID:10217294]
ChEMBL	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)	B	9.22	pKi	0.61	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	Binding affinity for human cloned 5-hydroxytryptamine 2C receptor expressed in CHO cells using [3H]mesulergine as radioligand	B	8.13	pIC50	7.41	nM	IC50	Bioorg Med Chem Lett (2002) 12: 243-248 [PMID:11755364]
ChEMBL	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)	B	8.94	pIC50	1.16	nM	IC50	DrugMatrix in vitro pharmacology data
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL324] [GtoPdb: 8] [UniProtKB: P08909]
ChEMBL	The binding affinity at 5-hydroxytryptamine 2C receptor was determined using [3H]mesulergine	B	8.85	pKi	1.4	nM	Ki	J Med Chem (2002) 45: 3280-3285 [PMID:12109911]
GtoPdb	-	-	9.4	pKi	-	-	-	Psychopharmacology (Berl) (1996) 126: 234-40 [PMID:8876023]; J Neurochem (1997) 69: 1138-44 [PMID:9282936]
5-HT3E/5-HT3B/5-HT3A/5-HT3D/5-HT3C/Serotonin 3 (5-HT3) receptor in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2094132] [GtoPdb: 377, 374, 373, 376, 375] [UniProtKB: A5X5Y0, O95264, P46098, Q70Z44, Q8WXA8]
ChEMBL	Binding affinity for human cloned 5-hydroxytryptamine 3 receptor	B	5.85	pIC50	1412.54	nM	IC50	Bioorg Med Chem Lett (2002) 12: 243-248 [PMID:11755364]
ChEMBL	Binding affinity for human cloned 5-hydroxytryptamine 3 receptor	B	5.85	pIC50	1412.54	nM	IC50	Bioorg Med Chem Lett (2002) 12: 249-253 [PMID:11755365]
5-HT3A/5-HT3B/Serotonin 3 (5-HT3) receptor in Rat (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094116] [GtoPdb: 373, 374] [UniProtKB: P35563, Q9JJ16]
ChEMBL	The binding affinity at 5-hydroxytryptamine 3 receptor was determined using [3H]LY-278584	B	7.15	pKi	70	nM	Ki	J Med Chem (2002) 45: 3280-3285 [PMID:12109911]
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
ChEMBL	Binding affinity towards human 5-hydroxytryptamine 6 receptor was evaluated using [3H]-LSD as radioligand	B	7.26	pKi	55	nM	Ki	J Med Chem (2003) 46: 2795-2812 [PMID:12825922]
GtoPdb	-	-	7.3	pKi	-	-	-	J Neurochem (1996) 66: 47-56 [PMID:8522988]; Mol Pharmacol (1998) 54: 577-83 [PMID:9730917]; Mol Pharmacol (1997) 52: 515-523 [PMID:9284367]
ChEMBL	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide)	B	7.4	pKi	40	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide)	B	7.07	pIC50	85	nM	IC50	DrugMatrix in vitro pharmacology data
5-HT6 receptor in Rat [GtoPdb: 11] [UniProtKB: P31388]
GtoPdb	-	-	7.4	pKi	-	-	-	Mol Pharmacol (1993) 43: 320-7 [PMID:7680751]; Neuropharmacology (1997) 36: 713-20 [PMID:9225298]; Mol Pharmacol (1998) 54: 577-83 [PMID:9730917]
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969]
ChEMBL	Binding affinity towards rodent 5-hydroxytryptamine 7 receptor	B	5.1	pKi	8010	nM	Ki	J Med Chem (2003) 46: 2795-2812 [PMID:12825922]
ChEMBL	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	B	7.2	pKi	63.1	nM	Ki	J Med Chem (2003) 46: 5638-5650 [PMID:14667218]
ChEMBL	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	B	7.25	pKi	56	nM	Ki	J Med Chem (2005) 48: 1709-1712 [PMID:15771415]
GtoPdb	-	-	7.6	pKi	-	-	-	Br J Pharmacol (1997) 122: 126-32 [PMID:9298538]
ChEMBL	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor	B	6.94	pIC50	114.82	nM	IC50	Bioorg Med Chem Lett (2002) 12: 243-248 [PMID:11755364]
5-HT7 receptor in Mouse [GtoPdb: 12] [UniProtKB: P32304]
GtoPdb	-	-	7	pKi	-	-	-	Mol Pharmacol (1993) 44: 229-36 [PMID:8394987]
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3223] [GtoPdb: 12] [UniProtKB: P32305]
ChEMBL	Binding affinity towards rat 5-hydroxytryptamine 7 receptor	B	7	pKi	100	nM	Ki	J Med Chem (2003) 46: 2795-2812 [PMID:12825922]
ChEMBL	Binding affinity towards 5-hydroxytryptamine 7 receptor	B	7.2	pKi	63.1	nM	Ki	Bioorg Med Chem Lett (2000) 10: 1097-1100 [PMID:10843226]
GtoPdb	-	-	7.4	pKi	-	-	-	J Biol Chem (1993) 268: 18200-4 [PMID:8394362]; Proc Natl Acad Sci USA (1993) 90: 8547-51 [PMID:8397408]
SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645]
ChEMBL	DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)	B	5.96	pKi	1098	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)	B	5.68	pIC50	2068	nM	IC50	DrugMatrix in vitro pharmacology data
SERT/Serotonin transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL313] [GtoPdb: 928] [UniProtKB: P31652]
ChEMBL	Inhibition of serotonin (5-HT) uptake into rat brain synaptosomes	B	6	pKi	>1000	nM	Ki	J Med Chem (1984) 27: 943-946 [PMID:6747993]
ChEMBL	Inhibition the uptake of tritiated serotonin (5-HT) by the serotonin transporter SERT in rat synaptosomes	B	6	pKi	>1000	nM	Ki	J Med Chem (1987) 30: 1433-1454 [PMID:3039136]
ChEMBL	The binding affinity at the 5-HT reuptake sites determined using competition binding assay	B	5.54	pIC50	2900	nM	IC50	J Med Chem (2002) 45: 3280-3285 [PMID:12109911]
LPA1 receptor in Human [GtoPdb: 272] [UniProtKB: Q92633]
GtoPdb	-	-	7	pIC50	~100	nM	IC50	Eur J Pharmacol (2020) 873: 172963 [PMID:32007501]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]