mianserin [Ligand Id: 135] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL6437 (J16.389I, Mianserin, Tolvon)
  • α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348]
  • Alpha-1a adrenergic receptor in Bovine [ChEMBL: CHEMBL4892] [UniProtKB: P18130]
  • α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140]
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  • α1B-adrenoceptor in Human [GtoPdb: 23] [UniProtKB: P35368]
  • α1B-adrenoceptor/Alpha-1b adrenergic receptor in Rat [ChEMBL: CHEMBL315] [GtoPdb: 23] [UniProtKB: P15823]
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  • α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100]
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  • α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
  • Alpha-2a adrenergic receptor in Bovine [ChEMBL: CHEMBL4744] [UniProtKB: Q28838]
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  • α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
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  • α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825]
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  • D1 receptor/Dopamine D1 receptor in Human [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728]
  • D1 receptor/Dopamine D1 receptor in Rat [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901]
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  • D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
  • D2 receptor/Dopamine D2 receptor in Rat [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
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  • D3 receptor/Dopamine D3 receptor in Human [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
  • D3 receptor/Dopamine D3 receptor in Rat [ChEMBL: CHEMBL3138] [GtoPdb: 216] [UniProtKB: P19020]
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  • D4 receptor/Dopamine D4 receptor in Human [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
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  • H1 receptor/Histamine H1 receptor in Human [ChEMBL: CHEMBL231] [GtoPdb: 262] [UniProtKB: P35367]
  • Histamine H1 receptor in Guinea pig [ChEMBL: CHEMBL3943] [UniProtKB: P31389]
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  • H2 receptor/Histamine H2 receptor in Human [ChEMBL: CHEMBL1941] [GtoPdb: 263] [UniProtKB: P25021]
  • Histamine H2 receptor in Guinea pig [ChEMBL: CHEMBL2882] [UniProtKB: P47747]
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  • M1 receptor/Muscarinic acetylcholine receptor M1 in Human [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
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  • M2 receptor/Muscarinic acetylcholine receptor M2 in Human [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
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  • M3 receptor/Muscarinic acetylcholine receptor M3 in Human [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309]
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  • M4 receptor/Muscarinic acetylcholine receptor M4 in Human [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173]
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  • M5 receptor/Muscarinic acetylcholine receptor M5 in Human [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912]
  • M5 receptor/Muscarinic acetylcholine receptor M5 in Rat [ChEMBL: CHEMBL277] [GtoPdb: 17] [UniProtKB: P08911]
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  • NET/Norepinephrine transporter in Human [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975]
  • Norepinephrine transporter in Rat [ChEMBL: CHEMBL304] [UniProtKB: Q9WTR4]
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  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
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  • 5-HT1B receptor in Mouse [GtoPdb: 2] [UniProtKB: P28334]
  • 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564]
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  • 5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
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  • 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
  • 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842]
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  • 5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595]
  • 5-HT2B receptor in Rat [GtoPdb: 7] [UniProtKB: P30994]
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  • 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
  • 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Rat [ChEMBL: CHEMBL324] [GtoPdb: 8] [UniProtKB: P08909]
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  • 5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
  • 5-HT6 receptor in Rat [GtoPdb: 11] [UniProtKB: P31388]
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  • 5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969]
  • 5-HT7 receptor in Mouse [GtoPdb: 12] [UniProtKB: P32304]
  • 5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Rat [ChEMBL: CHEMBL3223] [GtoPdb: 12] [UniProtKB: P32305]
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  • LPA1 receptor in Human [GtoPdb: 272] [UniProtKB: Q92633]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348]
ChEMBL Inhibition of specific [3H]prazosin binding (0.2 nM) to rat brain membranes alpha-1 adrenergic receptor F 6.6 pKd 251.19 nM Kd J Med Chem (1984) 27: 495-503 [PMID:6142954]
GtoPdb - - 7.6 pKi - - - Jpn J Pharmacol (2001) 86: 189-95 [PMID:11459121]
ChEMBL Binding affinity for human cloned Alpha-1A adrenergic receptor B 6.39 pIC50 407.38 nM IC50 Bioorg Med Chem Lett (2002) 12: 243-248 [PMID:11755364]
ChEMBL Binding affinity for human cloned Alpha-1A adrenergic receptor B 6.39 pIC50 407.38 nM IC50 Bioorg Med Chem Lett (2002) 12: 249-253 [PMID:11755365]
Alpha-1a adrenergic receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4892] [UniProtKB: P18130]
ChEMBL Displacement of [3H]prazosin from calf cerebral cortex alpha-1 adrenergic receptor B 7.37 pKi 43 nM Ki J Med Chem (1984) 27: 1182-1185 [PMID:6088770]
ChEMBL Binding activity against alpha-1 adrenergic receptor from calf cerebral cortex, using [3H]-prazosin as the radioligand B 7.37 pKi 43 nM Ki J Med Chem (1983) 26: 1696-1701 [PMID:6139479]
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140]
ChEMBL DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin) B 7.04 pKi 91 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin) B 6.65 pIC50 224 nM IC50 DrugMatrix in vitro pharmacology data
ChEMBL Compound was tested for its inhibitory activity against Alpha-1 adrenergic receptor B 10.15 pIC50 0.07 nM IC50 J Med Chem (1999) 42: 3154-3162 [PMID:10447960]
α1B-adrenoceptor in Human [GtoPdb: 23] [UniProtKB: P35368]
GtoPdb - - 7.4 pKi - - - Jpn J Pharmacol (2001) 86: 189-95 [PMID:11459121]
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL315] [GtoPdb: 23] [UniProtKB: P15823]
ChEMBL DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) B 7.18 pKi 66 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) B 6.92 pIC50 119 nM IC50 DrugMatrix in vitro pharmacology data
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100]
ChEMBL DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) B 7.39 pKi 41 nM Ki DrugMatrix in vitro pharmacology data
GtoPdb - - 7.5 pKi - - - Jpn J Pharmacol (2001) 86: 189-95 [PMID:11459121]
ChEMBL DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) B 7.08 pIC50 83 nM IC50 DrugMatrix in vitro pharmacology data
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
ChEMBL DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) B 7.8 pKi 16 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor B 8.32 pKi 4.8 nM Ki J Med Chem (2005) 48: 1709-1712 [PMID:15771415]
ChEMBL DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) B 7.37 pIC50 43 nM IC50 DrugMatrix in vitro pharmacology data
ChEMBL Binding affinity for human cloned Alpha-2A adrenergic receptor B 7.68 pIC50 20.89 nM IC50 Bioorg Med Chem Lett (2002) 12: 243-248 [PMID:11755364]
Alpha-2a adrenergic receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4744] [UniProtKB: Q28838]
ChEMBL Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand B 7.77 pKi 17 nM Ki J Med Chem (1983) 26: 1696-1701 [PMID:6139479]
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
ChEMBL DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) B 7.62 pKi 24 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) B 7.28 pIC50 52 nM IC50 DrugMatrix in vitro pharmacology data
α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825]
ChEMBL DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) B 7.59 pKi 26 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL Inhibition of [3H]rauwolscine binding to Alpha-2C adrenergic receptor B 8.42 pKi 3.8 nM Ki J Med Chem (2005) 48: 1709-1712 [PMID:15771415]
ChEMBL DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) B 6.75 pIC50 179 nM IC50 DrugMatrix in vitro pharmacology data
ChEMBL Binding affinity for human cloned Alpha-2C adrenergic receptor B 7.37 pIC50 42.66 nM IC50 Bioorg Med Chem Lett (2002) 12: 243-248 [PMID:11755364]
ChEMBL Binding affinity for human cloned Alpha-2C adrenergic receptor B 7.37 pIC50 42.66 nM IC50 Bioorg Med Chem Lett (2002) 12: 249-253 [PMID:11755365]
D1 receptor/Dopamine D1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728]
ChEMBL DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) B 6.57 pKi 271 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) B 6.27 pIC50 543 nM IC50 DrugMatrix in vitro pharmacology data
D1 receptor/Dopamine D1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901]
ChEMBL Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1 B 5.85 pKi 1420 nM Ki J Med Chem (2005) 48: 1709-1712 [PMID:15771415]
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL Inhibition of [3H]-spiperone binding to human Dopamine receptor D2 B 5.66 pKi 2197 nM Ki J Med Chem (2005) 48: 1709-1712 [PMID:15771415]
ChEMBL Binding affinity for human cloned Dopamine receptor D2L B 5.15 pIC50 7079.46 nM IC50 Bioorg Med Chem Lett (2002) 12: 243-248 [PMID:11755364]
ChEMBL Binding affinity for human cloned Dopamine receptor D2L B 5.15 pIC50 7079.46 nM IC50 Bioorg Med Chem Lett (2002) 12: 249-253 [PMID:11755365]
D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
ChEMBL The binding affinity at the Dopamine receptor D2 determined using [3H]spiperone B 6 pKi 1000 nM Ki J Med Chem (2002) 45: 3280-3285 [PMID:12109911]
ChEMBL Binding affinity towards Dopamine receptor D2 at 1.0 uM concentration B 6.08 pKi 828 nM Ki J Med Chem (1987) 30: 1433-1454 [PMID:3039136]
ChEMBL Binding affinity for rat Dopamine receptor D2 B 5.45 pIC50 3548.13 nM IC50 Bioorg Med Chem Lett (2002) 12: 243-248 [PMID:11755364]
ChEMBL Binding affinity for rat Dopamine receptor D2 B 5.45 pIC50 3548.13 nM IC50 Bioorg Med Chem Lett (2002) 12: 249-253 [PMID:11755365]
D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
ChEMBL Inhibition of [125I]iodosulpiride binding to human Dopamine receptor D3 B 5.55 pKi 2841 nM Ki J Med Chem (2005) 48: 1709-1712 [PMID:15771415]
ChEMBL Binding affinity for human cloned Dopamine receptor D3 B 5.41 pIC50 3890.45 nM IC50 Bioorg Med Chem Lett (2002) 12: 243-248 [PMID:11755364]
ChEMBL Binding affinity for human cloned Dopamine receptor D3 B 5.41 pIC50 3890.45 nM IC50 Bioorg Med Chem Lett (2002) 12: 249-253 [PMID:11755365]
D3 receptor/Dopamine D3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3138] [GtoPdb: 216] [UniProtKB: P19020]
ChEMBL Tested for binding affinity against dopamine receptor D3 expressed in Sf9 cells. B 5.82 pKi 1524 nM Ki J Med Chem (1993) 36: 1499-1500 [PMID:8098771]
D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
ChEMBL Binding affinity for human cloned Dopamine receptor D4 B 5.48 pIC50 3311.31 nM IC50 Bioorg Med Chem Lett (2002) 12: 243-248 [PMID:11755364]
ChEMBL Binding affinity for human cloned Dopamine receptor D4 B 5.48 pIC50 3311.31 nM IC50 Bioorg Med Chem Lett (2002) 12: 249-253 [PMID:11755365]
DAT/Dopamine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL338] [GtoPdb: 927] [UniProtKB: P23977]
ChEMBL Inhibition of dopamine (DA) uptake into rat brain synaptosomes F 5 pKi >10000 nM Ki J Med Chem (1984) 27: 943-946 [PMID:6747993]
ChEMBL Inhibition of the uptake of tritiated dopamine (DA) in rat synaptosomes B 5 pKi >10000 nM Ki J Med Chem (1987) 30: 1433-1454 [PMID:3039136]
G-protein coupled receptor in Honeybee (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366519] [UniProtKB: Q9NG02]
ChEMBL Antagonist activity at Apis mellifera tyramine receptor TyR1 B 4.14 pIC50 73000 nM IC50 Pest Manag Sci (2013) 69: 126-134 [PMID:23129510]
H1 receptor/Histamine H1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL231] [GtoPdb: 262] [UniProtKB: P35367]
ChEMBL Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor B 8.77 pKi 1.7 nM Ki J Med Chem (2005) 48: 1709-1712 [PMID:15771415]
ChEMBL DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) B 9.76 pKi 0.17 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL Binding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligand B 8.47 pIC50 3.39 nM IC50 Bioorg Med Chem Lett (2002) 12: 243-248 [PMID:11755364]
ChEMBL DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) B 8.82 pIC50 1.51 nM IC50 DrugMatrix in vitro pharmacology data
Histamine H1 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3943] [UniProtKB: P31389]
ChEMBL Inhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 min B 9.07 pKi 0.85 nM Ki J Med Chem (1995) 38: 3351-3360 [PMID:7650688]
H2 receptor/Histamine H2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1941] [GtoPdb: 263] [UniProtKB: P25021]
ChEMBL DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine) B 6 pKi 992 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine) B 6 pIC50 1008 nM IC50 DrugMatrix in vitro pharmacology data
Histamine H2 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2882] [UniProtKB: P47747]
ChEMBL Inhibitory activity against brain adenylate cyclase Histamine H2 receptor F 6.06 pIC50 880 nM IC50 J Med Chem (1999) 42: 3154-3162 [PMID:10447960]
M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
ChEMBL DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) B 6.46 pKi 343 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) B 5.85 pIC50 1423 nM IC50 DrugMatrix in vitro pharmacology data
M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
ChEMBL DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine) B 6.42 pKi 383 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine) B 5.97 pIC50 1078 nM IC50 DrugMatrix in vitro pharmacology data
M3 receptor/Muscarinic acetylcholine receptor M3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309]
ChEMBL DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) B 6.53 pKi 298 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) B 5.85 pIC50 1405 nM IC50 DrugMatrix in vitro pharmacology data
M4 receptor/Muscarinic acetylcholine receptor M4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173]
ChEMBL DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) B 6.54 pKi 288 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) B 5.68 pIC50 2066 nM IC50 DrugMatrix in vitro pharmacology data
M5 receptor/Muscarinic acetylcholine receptor M5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912]
ChEMBL DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) B 6.64 pKi 230 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) B 6.49 pIC50 320 nM IC50 DrugMatrix in vitro pharmacology data
M5 receptor/Muscarinic acetylcholine receptor M5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL277] [GtoPdb: 17] [UniProtKB: P08911]
ChEMBL Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellum B 5.72 pIC50 1900 nM IC50 J Med Chem (1984) 27: 995-1003 [PMID:6747997]
NET/Norepinephrine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975]
ChEMBL DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) B 6.79 pKi 161 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) B 6.79 pIC50 163 nM IC50 DrugMatrix in vitro pharmacology data
Norepinephrine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL304] [UniProtKB: Q9WTR4]
ChEMBL Inhibition of [3H]nisoxetine binding to rat Norepinephrine transporter B 7 pKi 101 nM Ki J Med Chem (2005) 48: 1709-1712 [PMID:15771415]
ChEMBL Inhibition of norepinephrine (NE) into rat brain synaptosomes F 7.59 pKi 26 nM Ki J Med Chem (1984) 27: 943-946 [PMID:6747993]
ChEMBL Inhibition of uptake of tritiated norepinephrine (NE) in rat synaptosomes B 7.59 pKi 26 nM Ki J Med Chem (1987) 30: 1433-1454 [PMID:3039136]
ChEMBL The binding affinity at the Norepinephrine transporter reuptake sites determined using competition binding assay B 7.66 pIC50 22 nM IC50 J Med Chem (2002) 45: 3280-3285 [PMID:12109911]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL Binding affinity to 5HT1A receptor B 6.4 pKd 398.11 nM Kd J Med Chem (2009) 52: 6107-6125 [PMID:19754201]
ChEMBL The binding affinity at the 5-hydroxytryptamine 1A receptor determined using [3H]5-CT B 6.3 pKi >500 nM Ki J Med Chem (2002) 45: 3280-3285 [PMID:12109911]
ChEMBL Binding affinity for human cloned 5-hydroxytryptamine 1A receptor B 6.4 pIC50 398.11 nM IC50 Bioorg Med Chem Lett (2002) 12: 243-248 [PMID:11755364]
ChEMBL Binding affinity for human cloned 5-hydroxytryptamine 1A receptor B 6.4 pIC50 398.11 nM IC50 Bioorg Med Chem Lett (2002) 12: 249-253 [PMID:11755365]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
ChEMBL DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) B 6.3 pKi 498 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) B 6.06 pIC50 872 nM IC50 DrugMatrix in vitro pharmacology data
5-HT1B receptor in Mouse [GtoPdb: 2] [UniProtKB: P28334]
GtoPdb - - 8.3 pKi - - - Proc Natl Acad Sci USA (1992) 89: 3020-4 [PMID:1557407]
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564]
ChEMBL Binding affinity (Ki) to rat cortical membranes at 5-HT1B binding site by using [125 I] ICYP as a radioligand. B 5.33 pKi 4700 nM Ki J Med Chem (1987) 30: 1-12 [PMID:3543362]
5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
ChEMBL Binding affinity for human cloned 5-hydroxytryptamine 1D receptor B 6.42 pIC50 380.19 nM IC50 Bioorg Med Chem Lett (2002) 12: 243-248 [PMID:11755364]
ChEMBL Binding affinity for human cloned 5-hydroxytryptamine 1D receptor B 6.42 pIC50 380.19 nM IC50 Bioorg Med Chem Lett (2002) 12: 249-253 [PMID:11755365]
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
ChEMBL Displacement of [3H]ketanserin from human 5HT2A receptor expressed in tsA201 cell membranes after 1 hr by scintillation counting analysis B 7.57 pKi 27 nM Ki J Med Chem (2013) 56: 1211-1227 [PMID:23301527]
ChEMBL Displacement of [3H]ketanserin from human 5HT2A receptor expressed in tsA201 cell membranes after 1 hr by scintillation counting analysis B 7.57 pKi 26.92 nM Ki J Med Chem (2013) 56: 1211-1227 [PMID:23301527]
ChEMBL Antagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular calcium release measured for 90 secs by fluorescence assay F 8.09 pKi 8.13 nM Ki J Med Chem (2013) 56: 1211-1227 [PMID:23301527]
ChEMBL Antagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular calcium release measured for 90 secs by fluorescence assay F 8.09 pKi 8.1 nM Ki J Med Chem (2013) 56: 1211-1227 [PMID:23301527]
ChEMBL Inhibition of [125I]R91150 binding to human 5-hydroxytryptamine 2A receptor B 8.37 pKi 4.3 nM Ki J Med Chem (2005) 48: 1709-1712 [PMID:15771415]
ChEMBL Displacement of [3H]ketanserin from recombinant human 5-HT2A receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting method B 8.49 pKi 3.2 nM Ki Bioorg Med Chem Lett (2018) 28: 2039-2049 [PMID:29730027]
ChEMBL Displacement of [3H]-ketanserin from recombinant human 5HT2A receptor expressed in HEK293 cells measured after 1.5 hrs by microbeta scintillation counting analysis B 8.55 pKi 2.8 nM Ki Eur J Med Chem (2019) 166: 144-158 [PMID:30703658]
ChEMBL Displacement of [3H]ketanserin from human 5HT2A receptor expressed in HEK293 cells incubated for 1.5 hrs by Cheng-Prusoff analysis based microbeta scintillation counting method B 8.55 pKi 2.8 nM Ki Eur J Med Chem (2019) 180: 383-397 [PMID:31325785]
ChEMBL Displacement of [3H]-ketanserin from human 5-HT2A receptor expressed in CHO-K1 cell membranes after 60 mins by scintillation counting method B 8.66 pKi 2.2 nM Ki Eur J Med Chem (2017) 137: 108-116 [PMID:28575721]
ChEMBL Displacement of [3H]-ketanserin from human 5-HT2A receptor expressed in CHO-K1 cell membranes after 60 mins by microbeta scintillation counting analysis B 8.7 pKi 2 nM Ki Bioorg Med Chem (2018) 26: 527-535 [PMID:29269256]
ChEMBL Displacement of [3H]-ketanserin from recombinant human 5HT2A receptor expressed in CHOK1 cell membranes measured after 1 hr by microbeta counting method B 8.72 pKi 1.91 nM Ki Eur J Med Chem (2020) 191: 112149-112149 [PMID:32105980]
ChEMBL Displacement of [3H]-ketanserin from human 5-HT2A receptor expressed in CHOK1 cell membranes after 60 mins by microbeta scintillation counting method B 8.92 pKi 1.2 nM Ki Medchemcomm (2017) 8: 1690-1696 [PMID:30108880]
ChEMBL DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) B 9.3 pKi 0.5 nM Ki DrugMatrix in vitro pharmacology data
GtoPdb - - 9.6 pKi - - - Synapse (2000) 35: 79-95 [PMID:10611634];
Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733];
Cardiovasc Drugs Ther (2003) 17: 427-34 [PMID:15107597]
ChEMBL Binding affinity for human cloned Alpha-2A adrenergic receptor B 7.68 pIC50 20.89 nM IC50 Bioorg Med Chem Lett (2002) 12: 249-253 [PMID:11755365]
ChEMBL Binding affinity for human cloned 5-hydroxytryptamine 2A receptor expressed in L929 cells using [125I]R91150 as radioligand B 7.98 pIC50 10.47 nM IC50 Bioorg Med Chem Lett (2002) 12: 243-248 [PMID:11755364]
ChEMBL DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) B 8.75 pIC50 1.76 nM IC50 DrugMatrix in vitro pharmacology data
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842]
ChEMBL Displacement of [3H]-ketanserin from rat cerebral cortex 5HT2A receptor measured after 20 mins by liquid scintillation counter method B 7.74 pKi 18.4 nM Ki Bioorg Med Chem (2016) 24: 3994-4007 [PMID:27377863]
ChEMBL Displacement of [3H]ketanserin from 5HT2A in rat brain cerebral cortex after 20 mins by scintillation counting B 8.3 pKi 5 nM Ki Eur J Med Chem (2011) 46: 4474-4488 [PMID:21816515]
ChEMBL Displacement of [3H]Ketanserin from 5HT2A receptor in Rattus norvegicus (rat) cerebral cortex by filter binding assay B 8.46 pKi 3.5 nM Ki Med Chem Res (2008) 17: 507-514
ChEMBL Displacement of [3H]ketanserin (0.5 nM) from rat cerebral cortex 5-hydroxytryptamine 2A receptors B 8.6 pKi 2.5 nM Ki J Med Chem (2003) 46: 265-283 [PMID:12519065]
ChEMBL The binding affinity at 5-hydroxytryptamine 2A receptor was determined using [3H]ketanserin B 8.82 pKi 1.5 nM Ki J Med Chem (2002) 45: 3280-3285 [PMID:12109911]
GtoPdb - - 9 pKi - - - J Pharmacol Exp Ther (1998) 286: 85-90 [PMID:9655845];
Psychopharmacology (Berl.) (1996) 126: 234-40 [PMID:8876023]
5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595]
ChEMBL DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) B 8.33 pKi 4.64 nM Ki DrugMatrix in vitro pharmacology data
GtoPdb - - 8.8 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733];
Naunyn Schmiedebergs Arch Pharmacol (1998) 357: 17-24 [PMID:9459568];
Br J Pharmacol (1999) 127: 1075-82 [PMID:10455251]
ChEMBL DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) B 8.14 pIC50 7.29 nM IC50 DrugMatrix in vitro pharmacology data
5-HT2B receptor in Rat [GtoPdb: 7] [UniProtKB: P30994]
GtoPdb - - 7.3 pKi - - - Mol Pharmacol (1993) 43: 419-26 [PMID:8450835]
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
ChEMBL Evaluated for the binding affinity to porcine choroid plexus at 5-hydroxytryptamine 2C receptor binding site by using [3H]-MES as a radioligand. B 8 pKi 10 nM Ki J Med Chem (1987) 30: 1-12 [PMID:3543362]
ChEMBL Antagonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular calcium release measured for 90 secs by fluorescence assay F 8.09 pKi 8.13 nM Ki J Med Chem (2013) 56: 1211-1227 [PMID:23301527]
ChEMBL Antagonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular calcium release measured for 90 secs by fluorescence assay F 8.1 pKi 8 nM Ki J Med Chem (2013) 56: 1211-1227 [PMID:23301527]
ChEMBL Inhibition of [3H]mesulergine binding to human 5-hydroxytryptamine 2C receptor B 8.36 pKi 4.4 nM Ki J Med Chem (2005) 48: 1709-1712 [PMID:15771415]
ChEMBL Binding affinity of compound towards 5-hydroxytryptamine 1C receptor using [3H]mesulergine (1.2 nM) ligand in choroid Plexus pig was determined B 8.42 pKi 3.8 nM Ki J Med Chem (1997) 40: 952-960 [PMID:9083484]
ChEMBL Displacement of [3H]mesulergine from human 5HT2C receptor expressed in tsA201 cell membranes after 1 hr by scintillation counting analysis B 8.76 pKi 1.74 nM Ki J Med Chem (2013) 56: 1211-1227 [PMID:23301527]
ChEMBL Displacement of [3H]mesulergine from human 5HT2C receptor expressed in tsA201 cell membranes after 1 hr by scintillation counting analysis B 8.77 pKi 1.7 nM Ki J Med Chem (2013) 56: 1211-1227 [PMID:23301527]
GtoPdb - - 9.2 pKi - - - Synapse (2000) 35: 79-95 [PMID:10611634];
Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733];
J Neurochem (1999) 72: 2127-34 [PMID:10217294]
ChEMBL DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) B 9.22 pKi 0.61 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL Binding affinity for human cloned 5-hydroxytryptamine 2C receptor expressed in CHO cells using [3H]mesulergine as radioligand B 8.13 pIC50 7.41 nM IC50 Bioorg Med Chem Lett (2002) 12: 243-248 [PMID:11755364]
ChEMBL DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) B 8.94 pIC50 1.16 nM IC50 DrugMatrix in vitro pharmacology data
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL324] [GtoPdb: 8] [UniProtKB: P08909]
ChEMBL The binding affinity at 5-hydroxytryptamine 2C receptor was determined using [3H]mesulergine B 8.85 pKi 1.4 nM Ki J Med Chem (2002) 45: 3280-3285 [PMID:12109911]
GtoPdb - - 9.4 pKi - - - Psychopharmacology (Berl.) (1996) 126: 234-40 [PMID:8876023];
J Neurochem (1997) 69: 1138-44 [PMID:9282936]
5-HT3E/5-HT3B/5-HT3A/5-HT3D/5-HT3C/Serotonin 3 (5-HT3) receptor in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2094132] [GtoPdb: 377, 374, 373, 376, 375] [UniProtKB: A5X5Y0, O95264, P46098, Q70Z44, Q8WXA8]
ChEMBL Binding affinity for human cloned 5-hydroxytryptamine 3 receptor B 5.85 pIC50 1412.54 nM IC50 Bioorg Med Chem Lett (2002) 12: 243-248 [PMID:11755364]
ChEMBL Binding affinity for human cloned 5-hydroxytryptamine 3 receptor B 5.85 pIC50 1412.54 nM IC50 Bioorg Med Chem Lett (2002) 12: 249-253 [PMID:11755365]
5-HT3A/5-HT3B/Serotonin 3 (5-HT3) receptor in Rat (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094116] [GtoPdb: 373, 374] [UniProtKB: P35563, Q9JJ16]
ChEMBL The binding affinity at 5-hydroxytryptamine 3 receptor was determined using [3H]LY-278584 B 7.15 pKi 70 nM Ki J Med Chem (2002) 45: 3280-3285 [PMID:12109911]
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
ChEMBL Binding affinity towards human 5-hydroxytryptamine 6 receptor was evaluated using [3H]-LSD as radioligand B 7.26 pKi 55 nM Ki J Med Chem (2003) 46: 2795-2812 [PMID:12825922]
GtoPdb - - 7.3 pKi - - - J Neurochem (1996) 66: 47-56 [PMID:8522988];
Mol Pharmacol (1998) 54: 577-583 [PMID:9730917];
Mol Pharmacol (1997) 52: 515-523 [PMID:9284367]
ChEMBL DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide) B 7.4 pKi 40 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide) B 7.07 pIC50 85 nM IC50 DrugMatrix in vitro pharmacology data
5-HT6 receptor in Rat [GtoPdb: 11] [UniProtKB: P31388]
GtoPdb - - 7.4 pKi - - - Mol Pharmacol (1993) 43: 320-7 [PMID:7680751];
Neuropharmacology (1997) 36: 713-20 [PMID:9225298];
Mol Pharmacol (1998) 54: 577-583 [PMID:9730917]
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969]
ChEMBL Binding affinity towards rodent 5-hydroxytryptamine 7 receptor B 5.1 pKi 8010 nM Ki J Med Chem (2003) 46: 2795-2812 [PMID:12825922]
ChEMBL Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor B 7.2 pKi 63.1 nM Ki J Med Chem (2003) 46: 5638-5650 [PMID:14667218]
ChEMBL Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor B 7.25 pKi 56 nM Ki J Med Chem (2005) 48: 1709-1712 [PMID:15771415]
GtoPdb - - 7.6 pKi - - - Br J Pharmacol (1997) 122: 126-32 [PMID:9298538]
ChEMBL Binding affinity for human cloned 5-hydroxytryptamine 7 receptor B 6.94 pIC50 114.82 nM IC50 Bioorg Med Chem Lett (2002) 12: 243-248 [PMID:11755364]
5-HT7 receptor in Mouse [GtoPdb: 12] [UniProtKB: P32304]
GtoPdb - - 7 pKi - - - Mol Pharmacol (1993) 44: 229-36 [PMID:8394987]
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3223] [GtoPdb: 12] [UniProtKB: P32305]
ChEMBL Binding affinity towards rat 5-hydroxytryptamine 7 receptor B 7 pKi 100 nM Ki J Med Chem (2003) 46: 2795-2812 [PMID:12825922]
ChEMBL Binding affinity towards 5-hydroxytryptamine 7 receptor B 7.2 pKi 63.1 nM Ki Bioorg Med Chem Lett (2000) 10: 1097-1100 [PMID:10843226]
GtoPdb - - 7.4 pKi - - - J Biol Chem (1993) 268: 18200-4 [PMID:8394362];
Proc Natl Acad Sci USA (1993) 90: 8547-51 [PMID:8397408]
SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645]
ChEMBL DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) B 5.96 pKi 1098 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) B 5.68 pIC50 2068 nM IC50 DrugMatrix in vitro pharmacology data
SERT/Serotonin transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL313] [GtoPdb: 928] [UniProtKB: P31652]
ChEMBL Inhibition of serotonin (5-HT) uptake into rat brain synaptosomes B 6 pKi >1000 nM Ki J Med Chem (1984) 27: 943-946 [PMID:6747993]
ChEMBL Inhibition the uptake of tritiated serotonin (5-HT) by the serotonin transporter SERT in rat synaptosomes B 6 pKi >1000 nM Ki J Med Chem (1987) 30: 1433-1454 [PMID:3039136]
ChEMBL The binding affinity at the 5-HT reuptake sites determined using competition binding assay B 5.54 pIC50 2900 nM IC50 J Med Chem (2002) 45: 3280-3285 [PMID:12109911]
LPA1 receptor in Human [GtoPdb: 272] [UniProtKB: Q92633]
GtoPdb - - 7 pIC50 ~100 nM IC50 Eur J Pharmacol (2020) 873: 172963 [PMID:32007501]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]