AZD1981 [Ligand Id: 7680] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1914489 (Azd1981, Azd 1981, Azd-1981, AZD-1981)
  • aldo-keto reductase family 1 member B/Aldose reductase in Human [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121]
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  • DP2 receptor/G protein-coupled receptor 44 in Human [ChEMBL: CHEMBL5071] [GtoPdb: 339] [UniProtKB: Q9Y5Y4]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
aldo-keto reductase family 1 member B/Aldose reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121]
ChEMBL Inhibition of human recombinant aldose reductase 1 after 15 mins by spectrophotometry analysis B 6.1 pIC50 794 nM IC50 Bioorg Med Chem Lett (2011) 21: 6288-6292 [PMID:21944852]
DP2 receptor/G protein-coupled receptor 44 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5071] [GtoPdb: 339] [UniProtKB: Q9Y5Y4]
ChEMBL Antagonist activity against human CRTh2 receptor in human eosinophils assessed as inhibition of DK-PGD2-induced CD11b expression F 8 pIC50 10 nM IC50 Bioorg Med Chem Lett (2011) 21: 6288-6292 [PMID:21944852]
ChEMBL Displacement of [3H]PGD2 from human CRTH2 receptor B 8.37 pIC50 4.3 nM IC50 Bioorg Med Chem Lett (2011) 21: 6288-6292 [PMID:21944852]
ChEMBL Displacement of [3H]PGD2 from recombinant human CRTH2 expressed in HEK293 cells after 2 hrs by microbeta scintillation counting B 8.37 pIC50 4.3 nM IC50 J Med Chem (2012) 55: 2915-2931 [PMID:22224640]
GtoPdb Displacement of [3H]PGD2 from human DP2 receptor - 8.37 pIC50 4.3 nM IC50 Bioorg Med Chem Lett (2011) 21: 6288-92 [PMID:21944852]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]