compound I3 [PMID: 23428964] [Ligand Id: 8565] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1852660 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Aminopeptidase N in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1907] [GtoPdb: 1560] [UniProtKB: P15144] | ||||||||
| ChEMBL | Inhibition of human APN using L-leucine-p-nitroanilide as substrate measured every 10 mins for 2 hrs by spectrophotometric analysis | B | 9.46 | pKi | 0.35 | nM | Ki | Bioorg Med Chem (2013) 21: 2135-2144 [PMID:23428964] |
| GtoPdb | - | - | 9.46 | pKi | 0.35 | nM | Ki | Bioorg Med Chem (2013) 21: 2135-44 [PMID:23428964] |
| Aminopeptidase N in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2590] [UniProtKB: P15145] | ||||||||
| ChEMBL | Inhibition of pig APN using L-leucine-p-nitroanilide as substrate measured every 10 mins for 2 hrs by spectrophotometric analysis | B | 10.22 | pKi | 0.06 | nM | Ki | Bioorg Med Chem (2013) 21: 2135-2144 [PMID:23428964] |
| Aminopeptidase N in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2189140] [GtoPdb: 1560] [UniProtKB: P97449] | ||||||||
| ChEMBL | Inhibition of mouse APN using L-leucine-p-nitroanilide as substrate measured every 10 mins for 2 hrs by spectrophotometric analysis | B | 9.7 | pKi | 0.2 | nM | Ki | Bioorg Med Chem (2013) 21: 2135-2144 [PMID:23428964] |
| GtoPdb | - | - | 9.7 | pKi | 0.2 | nM | Ki | Bioorg Med Chem (2013) 21: 2135-44 [PMID:23428964] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
