ChEMBL ligand: CHEMBL1852660
Aminopeptidase N in Human [ChEMBL: CHEMBL1907] [GtoPdb: 1560] [UniProtKB: P15144] Aminopeptidase N in Pig [ChEMBL: CHEMBL2590] [UniProtKB: P15145] Aminopeptidase N in Mouse [ChEMBL: CHEMBL2189140] [GtoPdb: 1560] [UniProtKB: P97449] There should be some charts here, you may need to enable JavaScript!
Endoplasmic reticulum aminopeptidase 1 in Human [ChEMBL: CHEMBL5939] [GtoPdb: 1566] [UniProtKB: Q9NZ08] There should be some charts here, you may need to enable JavaScript!
Endoplasmic reticulum aminopeptidase 2 in Human [ChEMBL: CHEMBL5043] [GtoPdb: 1567] [UniProtKB: Q6P179] There should be some charts here, you may need to enable JavaScript!
Interleukin-1 receptor antagonist protein in Human [ChEMBL: CHEMBL4523191] [UniProtKB: P18510] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Aminopeptidase N in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1907] [GtoPdb: 1560] [UniProtKB: P15144]
ChEMBL	Inhibition of human APN using L-leucine-p-nitroanilide as substrate measured every 10 mins for 2 hrs by spectrophotometric analysis	B	9.46	pKi	0.35	nM	Ki	Bioorg Med Chem (2013) 21: 2135-2144 [PMID:23428964]
GtoPdb	-	-	9.46	pKi	0.35	nM	Ki	Bioorg Med Chem (2013) 21: 2135-44 [PMID:23428964]
Aminopeptidase N in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2590] [UniProtKB: P15145]
ChEMBL	Inhibition of pig APN using L-leucine-p-nitroanilide as substrate measured every 10 mins for 2 hrs by spectrophotometric analysis	B	10.22	pKi	0.06	nM	Ki	Bioorg Med Chem (2013) 21: 2135-2144 [PMID:23428964]
Aminopeptidase N in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2189140] [GtoPdb: 1560] [UniProtKB: P97449]
ChEMBL	Inhibition of mouse APN using L-leucine-p-nitroanilide as substrate measured every 10 mins for 2 hrs by spectrophotometric analysis	B	9.7	pKi	0.2	nM	Ki	Bioorg Med Chem (2013) 21: 2135-2144 [PMID:23428964]
GtoPdb	-	-	9.7	pKi	0.2	nM	Ki	Bioorg Med Chem (2013) 21: 2135-44 [PMID:23428964]
Endoplasmic reticulum aminopeptidase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5939] [GtoPdb: 1566] [UniProtKB: Q9NZ08]
ChEMBL	Inhibition of human recombinant ERAP1 expressed in baculovirus infected sf9 cells using L-AMC as substrate incubated for 5 to 10 mins by Michaelis-Menten analysis	B	5.8	pIC50	1600	nM	IC50	J Med Chem (2024) 67: 11597-11621 [PMID:39011823]
Endoplasmic reticulum aminopeptidase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5043] [GtoPdb: 1567] [UniProtKB: Q6P179]
ChEMBL	Inhibition of human recombinant ERAP2 expressed in baculovirus infected sf9 cells using R-AMC as substrate incubated for 5 to 10 mins by Michaelis-Menten analysis	B	6.41	pIC50	390	nM	IC50	J Med Chem (2024) 67: 11597-11621 [PMID:39011823]
Interleukin-1 receptor antagonist protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523191] [UniProtKB: P18510]
ChEMBL	Inhibition of human recombinant IRAP expressed in baculovirus infected Sf9 cells using L-AMC as substrate incubated for 5 to 10 mins by Michaelis-Menten analysis	B	6.92	pIC50	120	nM	IC50	J Med Chem (2024) 67: 11597-11621 [PMID:39011823]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]