Ligand id: 8451

Name: demcizumab

Compound class Antibody
International Nonproprietary Names
INN number INN
9572 demcizumab
Demcizumab is a humanised IgG2 monoclonal antibody targeting DLL4 (delta like canonical Notch ligand 4), a membrane bound Notch receptor ligand expressed predominantly on vascular endothelial cells.
Peptide sequence information for this antibody is available from its IMGT/mAb-DB record. A BLAST search using the peptide sequence of the variable region of the heavy chain forming demcizumab reveals US7750124 B2 as the covering patent [1].
Database Links
Specialist databases
IMGT/mAb-DB 415
Other databases
GtoPdb PubChem SID 252166661
Search PubMed clinical trials demcizumab
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Wikipedia Demcizumab