SP-4206 [Ligand Id: 9037] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL429852 (SP-4206) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Interleukin-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5880] [UniProtKB: P60568] | ||||||||
| ChEMBL | Binding affinity to IL2 (unknown origin) by SPR assay | B | 7 | pKd | 100 | nM | Kd | J Med Chem (2021) 64: 17496-17510 [PMID:34821503] |
| ChEMBL | Binding affinity to IL2 assessed as inhibition of IL2-IL2Ralpha interaction | B | 7.22 | pKi | 60 | nM | Ki | Nature (2007) 450: 1001-1009 [PMID:18075579] |
| ChEMBL | Inhibition of IL-2 (unknown origin) | B | 4.22 | pIC50 | 60000 | nM | IC50 | Bioorg Med Chem Lett (2021) 48: 128229-128229 [PMID:34214508] |
| ChEMBL | Binding affinity to IL2 (unknown origin) assessed as inhibition of binding to IL2 receptor alpha | B | 7.22 | pIC50 | 60 | nM | IC50 | Med Chem Res (2013) 22: 5739-5751 |
| Interleukin-2 receptor subunit α/Interleukin-2 receptor alpha chain in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3287] [GtoPdb: 1695] [UniProtKB: P01590] | ||||||||
| ChEMBL | Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay | B | 7.22 | pIC50 | 60 | nM | IC50 | J Med Chem (2004) 47: 3111-3130 [PMID:15163192] |
| ChEMBL | Effective concentration required against phosphorylation of Mammary gland factor/STAT5 | F | 8.52 | pEC50 | 3 | nM | EC50 | J Med Chem (2004) 47: 3111-3130 [PMID:15163192] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
