compound 3v [PMID: 27390066] [Ligand Id: 9683] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3806197 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Aminopeptidase N in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1907] [GtoPdb: 1560] [UniProtKB: P15144] | ||||||||
| ChEMBL | Inhibition of recombinant human alanyl aminopeptidase M1 using Ala-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition measured for 15 mins by spectrofluorimetric analysis | B | 7.19 | pKi | 65 | nM | Ki | Eur J Med Chem (2016) 117: 187-196 [PMID:27100031] |
| Aminopeptidase N in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2590] [UniProtKB: P15145] | ||||||||
| ChEMBL | Inhibition of pig kidney alanyl aminopeptidase M1 using Ala-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition measured for 15 mins by spectrofluorimetric analysis | B | 6.14 | pKi | 723 | nM | Ki | Eur J Med Chem (2016) 117: 187-196 [PMID:27100031] |
| Cytosol aminopeptidase in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5624] [UniProtKB: P28839] | ||||||||
| ChEMBL | Inhibition of porcine kidney leucine aminopeptidase M17 using Leu-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition measured for 15 mins by spectrofluorimetric analysis | B | 4.71 | pKi | 19500 | nM | Ki | Eur J Med Chem (2016) 117: 187-196 [PMID:27100031] |
| Endoplasmic reticulum aminopeptidase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5043] [GtoPdb: 1567] [UniProtKB: Q6P179] | ||||||||
| ChEMBL | Inhibition of human ERAP2 preincubated for 30 to 60 mins followed by addition of Arg-AMC as substrate measured for 15 mins by spectrofluorimetric method | B | 5.77 | pKi | 1680 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 4122-4126 [PMID:27390066] |
| GtoPdb | - | - | 6.21 | pKi | 620 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 4122-6 [PMID:27390066] |
| Endoplasmic reticulum aminopeptidase 1 in Human [GtoPdb: 1566] [UniProtKB: Q9NZ08] | ||||||||
| GtoPdb | - | - | 3.6 | pKi | >250000 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 4122-6 [PMID:27390066] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
