ChEMBL ligand: CHEMBL1812545
indoleamine 2,3-dioxygenase 1/Indoleamine 2,3-dioxygenase in Human [ChEMBL: CHEMBL4685] [GtoPdb: 2829] [UniProtKB: P14902] There should be some charts here, you may need to enable JavaScript!
indoleamine 2,3-dioxygenase 1/Indoleamine 2,3-dioxygenase 1 in Mouse [ChEMBL: CHEMBL1075294] [GtoPdb: 2829] [UniProtKB: P28776] There should be some charts here, you may need to enable JavaScript!
tryptophan 2,3-dioxygenase/Tryptophan 2,3-dioxygenase in Human [ChEMBL: CHEMBL2140] [GtoPdb: 2887] [UniProtKB: P48775] tryptophan 2,3-dioxygenase/Tryptophan 2,3-dioxygenase in Mouse [ChEMBL: CHEMBL1075307] [GtoPdb: 2887] [UniProtKB: P48776] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
indoleamine 2,3-dioxygenase 1/Indoleamine 2,3-dioxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4685] [GtoPdb: 2829] [UniProtKB: P14902]
ChEMBL	Inhibition of human IDO1 transfected in mouse P815B clone-6 cells by HPLC analysis	B	4	pIC50	>100000	nM	IC50	J Med Chem (2012) 55: 5270-5290 [PMID:22616902]
indoleamine 2,3-dioxygenase 1/Indoleamine 2,3-dioxygenase 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075294] [GtoPdb: 2829] [UniProtKB: P28776]
ChEMBL	Inhibition of mouse IDO1 in P815 clone 6 cells by HPLC analysis	B	4	pIC50	>100000	nM	IC50	J Med Chem (2012) 55: 5270-5290 [PMID:22616902]
tryptophan 2,3-dioxygenase/Tryptophan 2,3-dioxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2140] [GtoPdb: 2887] [UniProtKB: P48775]
ChEMBL	Uncompetitive inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 mins by Dixon plot analysis	B	5.13	pKi	7470	nM	Ki	Eur J Med Chem (2018) 160: 133-145 [PMID:30321802]
GtoPdb	-	-	5.25	pKi	5600	nM	Ki	Proc Natl Acad Sci USA (2012) 109: 2497-502 [PMID:22308364]; J Med Chem (2011) 54: 5320-34 [PMID:21726069]
ChEMBL	Competitive inhibition of human recombinant TDO expressed in Escherichia coli BL21 using L-tryptophan as substrate by measuring conversion of N-formylkynurenine into kynurenine after 30 mins by Michaelis-Menten steady state analysis	B	5.25	pKi	5600	nM	Ki	J Med Chem (2011) 54: 5320-5334 [PMID:21726069]
ChEMBL	Inhibition of recombinant human TDO expressed in Escherichia coli using L-Trp as substrate after 10 to 60 mins	B	5.25	pKi	5600	nM	Ki	Eur J Med Chem (2018) 160: 133-145 [PMID:30321802]
ChEMBL	Inhibition of TDO (unknown origin)	B	5.26	pKi	5500	nM	Ki	Bioorg Med Chem (2019) 27: 1087-1098 [PMID:30773421]
ChEMBL	Inhibition of human TDO transfected in mouse P815B clone 19 cells by HPLC analysis	B	4.55	pIC50	28000	nM	IC50	J Med Chem (2012) 55: 5270-5290 [PMID:22616902]
ChEMBL	Inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 mins	B	4.73	pIC50	18700	nM	IC50	Eur J Med Chem (2018) 160: 133-145 [PMID:30321802]
ChEMBL	Inhibition of recombinant human TDO expressed in Escherichia coli BL21 using L-Trp as substrate incubated for 30 mins by enzymatic assay	B	4.94	pIC50	11580	nM	IC50	Bioorg Med Chem Lett (2020) 30: 127159-127159 [PMID:32247733]
ChEMBL	Inhibition of recombinant human TDO2 expressed in Escherichia coli BL21 (DE3) assessed as reduction in N-formylkynurenine formation using L-tryptophan as substrate measured after 40 mins by methylene blue reagent based spectrophotometry	B	5.21	pIC50	6100	nM	IC50	J Med Chem (2021) 64: 10967-10980 [PMID:34338527]
ChEMBL	Inhibition of human TDO2 expressed in mouse P815B cells assessed as kynurenine concentration formation using L-tryptophan as substrate incubated for 7 hrs by UPLC analysis	B	5.76	pIC50	1740	nM	IC50	J Med Chem (2021) 64: 10967-10980 [PMID:34338527]
ChEMBL	Inhibition of TDO in human U87 MG cells using L-Trp as substrate after 8 hrs	B	6.17	pIC50	671	nM	IC50	Eur J Med Chem (2018) 160: 133-145 [PMID:30321802]
ChEMBL	Inhibition of human recombinant pEF6/V5-His-tagged TDO2 transfected in HEK293-EBNA cells using L-tryptophan as substrate by HPLC analysis	B	6.21	pIC50	620	nM	IC50	J Med Chem (2019) 62: 9161-9174 [PMID:31580660]
ChEMBL	Inhibition of human TDO	B	6.21	pIC50	620	nM	IC50	J Med Chem (2015) 58: 8762-8782 [PMID:26207924]
GtoPdb	Concentration inhibiting TDO activity by 50% in a cellular assay, at 80μM L-tryptophan.	-	6.21	pIC50	620	nM	IC50	Proc Natl Acad Sci USA (2012) 109: 2497-502 [PMID:22308364]
ChEMBL	Inhibition of TDO (unknown origin) expressed in HEK293 cells using L-Trp as substrate after 8 hrs	B	6.4	pIC50	398	nM	IC50	Eur J Med Chem (2018) 160: 133-145 [PMID:30321802]
tryptophan 2,3-dioxygenase/Tryptophan 2,3-dioxygenase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075307] [GtoPdb: 2887] [UniProtKB: P48776]
ChEMBL	Inhibition of mouse TDO in P815 clone 12 cells by HPLC analysis	B	4.77	pIC50	17000	nM	IC50	J Med Chem (2012) 55: 5270-5290 [PMID:22616902]
ChEMBL	Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs by HPLC analysis	B	5.7	pIC50	2000	nM	IC50	J Med Chem (2011) 54: 5320-5334 [PMID:21726069]
ChEMBL	Inhibition of mouse TDO	B	5.71	pIC50	1960	nM	IC50	J Med Chem (2015) 58: 8762-8782 [PMID:26207924]
GtoPdb	Concentration inhibiting TDO activity by 50% in a cellular assay, at 80μM L-tryptophan.	-	5.71	pIC50	1960	nM	IC50	Proc Natl Acad Sci USA (2012) 109: 2497-502 [PMID:22308364]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]