BI 653048   Click here for help

GtoPdb Ligand ID: 9715

Synonyms: (R)-39 [2] | BI 653048 BS H3PO4 [3] | BI-653048 | BI653048
Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: BI 653048 is a "dissociated" glucocorticoid receptor (GR) agonist (displaying different transcriptional regulatory profiles between gene transrepression and transactivation). This type of drug is designed to reduce the unwanted side-effects common to traditional GR agonists [1-2]. It has favourable drug-like properties, but because it has reduced mouse functional transrepression potency it is not suitable for evaluation in standard preclinical mouse models. BI 653048 is synthesised as the phosphoric acid (H3PO4) cocrystal to optimise physicochemical properties, stability characteristics, solubility and bioavailability compared to the free form [3].
This ligand is one of the compounds available from Boehringer Ingelheim's opnMe molecular library.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 9
Topological polar surface area 134.52
Molecular weight 515.15
XLogP 4.32
No. Lipinski's rules broken 0
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Canonical SMILES CCS(=O)(=O)c1ncc2c(c1)cc([nH]2)CC(C(F)(F)F)(CC(c1ccc(cc1C(=O)N)F)(C)C)O
Isomeric SMILES CCS(=O)(=O)c1ncc2c(c1)cc([nH]2)C[C@@](C(F)(F)F)(CC(c1ccc(cc1C(=O)N)F)(C)C)O
InChI InChI=1S/C23H25F4N3O4S/c1-4-35(33,34)19-8-13-7-15(30-18(13)11-29-19)10-22(32,23(25,26)27)12-21(2,3)17-6-5-14(24)9-16(17)20(28)31/h5-9,11,30,32H,4,10,12H2,1-3H3,(H2,28,31)/t22-/m0/s1
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
Synonyms Click here for help
(R)-39 [2] | BI 653048 BS H3PO4 [3] | BI-653048 | BI653048
Database Links Click here for help
BindingDB Ligand 50041896
ChEMBL Ligand CHEMBL3358954
GtoPdb PubChem SID 348353674
PubChem CID 44543970
Search Google for chemical match using the InChIKey AUIFRJWXYUNPPV-QFIPXVFZSA-N
Search Google for chemicals with the same backbone AUIFRJWXYUNPPV
UniChem Compound Search for chemical match using the InChIKey AUIFRJWXYUNPPV-QFIPXVFZSA-N
UniChem Connectivity Search for chemical match using the InChIKey AUIFRJWXYUNPPV-QFIPXVFZSA-N