compound 5m [PMID: 20483621] [Ligand Id: 8206] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1163559
  • ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73]
ChEMBL Inhibition of ALK phosphorylation in human Karpas-299 cells by immunoblotting and ELISA B 6.6 pIC50 250 nM IC50 Bioorg. Med. Chem. (2010) 18: 4351-4362 [PMID:20483621]
GtoPdb - - 8 pIC50 10 nM IC50 Bioorg Med Chem (2010) 18: 4351-62 [PMID:20483621]
ChEMBL Inhibition of ALK by time-resolved fluorescence assay B 8 pIC50 10 nM IC50 Bioorg. Med. Chem. (2010) 18: 4351-4362 [PMID:20483621]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]