ChEMBL ligand: CHEMBL3341789
activin A receptor type 1/Activin receptor type-1 in Human [ChEMBL: CHEMBL5903] [GtoPdb: 1785] [UniProtKB: Q04771] There should be some charts here, you may need to enable JavaScript!
bone morphogenetic protein receptor type IA/Bone morphogenetic protein receptor type-1A in Human [ChEMBL: CHEMBL5275] [GtoPdb: 1786] [UniProtKB: P36894] There should be some charts here, you may need to enable JavaScript!
activin A receptor type IL/Serine/threonine-protein kinase receptor R3 in Human [ChEMBL: CHEMBL5311] [GtoPdb: 1784] [UniProtKB: P37023] There should be some charts here, you may need to enable JavaScript!
receptor interacting serine/threonine kinase 2/Serine/threonine-protein kinase RIPK2 in Human [ChEMBL: CHEMBL5014] [GtoPdb: 2190] [UniProtKB: O43353] There should be some charts here, you may need to enable JavaScript!
transforming growth factor beta receptor 1/TGF-beta receptor type I in Human [ChEMBL: CHEMBL4439] [GtoPdb: 1788] [UniProtKB: P36897] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
activin A receptor type 1/Activin receptor type-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5903] [GtoPdb: 1785] [UniProtKB: Q04771]
ChEMBL	Inhibition of human ALK2 using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assay	B	6.94	pIC50	115	nM	IC50	J Med Chem (2020) 63: 4978-4996 [PMID:32369358]
ChEMBL	Inhibition of ALK2 (unknown origin) expressed in HEK293T cells after 30 mins by luciferase reporter gene assay	B	7.57	pIC50	27	nM	IC50	J Med Chem (2014) 57: 7900-7915 [PMID:25101911]
ChEMBL	Inhibition of human recombinant human ALK2 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P]	B	7.62	pIC50	24	nM	IC50	J Med Chem (2014) 57: 7900-7915 [PMID:25101911]
ChEMBL	Inhibition of human N-terminal His-tagged TEV protease site linked ALK2 Q207D mutant (201 to 499 residues) expressed in baculovirus infected Sf9 insect cells	B	7.62	pIC50	24	nM	IC50	J Med Chem (2020) 63: 4978-4996 [PMID:32369358]
ChEMBL	Inhibition of human ALK2 using casein as substrate in presence of 10 uM [gamma33P] ATP by kinase assay	B	7.62	pIC50	24	nM	IC50	Eur J Med Chem (2020) 200: 112417-112417 [PMID:32505849]
GtoPdb	-	-	7.62	pIC50	24	nM	IC50	J Med Chem (2014) 57: 7900-15 [PMID:25101911]
bone morphogenetic protein receptor type IA/Bone morphogenetic protein receptor type-1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5275] [GtoPdb: 1786] [UniProtKB: P36894]
GtoPdb	-	-	5.93	pIC50	1171	nM	IC50	J Med Chem (2014) 57: 7900-15 [PMID:25101911]
ChEMBL	Inhibition of ALK3 (unknown origin) expressed in HEK293T cells after 30 mins by luciferase reporter gene assay	B	5.93	pIC50	1171	nM	IC50	J Med Chem (2014) 57: 7900-7915 [PMID:25101911]
activin A receptor type IL/Serine/threonine-protein kinase receptor R3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5311] [GtoPdb: 1784] [UniProtKB: P37023]
ChEMBL	Inhibition of ALK1 (unknown origin) expressed in HEK293T cells after 30 mins by luciferase reporter gene assay	B	7.57	pIC50	27	nM	IC50	J Med Chem (2014) 57: 7900-7915 [PMID:25101911]
GtoPdb	-	-	7.57	pIC50	27	nM	IC50	J Med Chem (2014) 57: 7900-15 [PMID:25101911]
receptor interacting serine/threonine kinase 2/Serine/threonine-protein kinase RIPK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5014] [GtoPdb: 2190] [UniProtKB: O43353]
ChEMBL	Inhibition of recombinant human RIPK2 incubated for 2 hr by ADP-Glo assay	B	7	pIC50	100	nM	IC50	Eur J Med Chem (2020) 200: 112417-112417 [PMID:32505849]
transforming growth factor beta receptor 1/TGF-beta receptor type I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4439] [GtoPdb: 1788] [UniProtKB: P36897]
ChEMBL	Inhibition of TGFbeta1-induced TGFbeta type 1 ALK5 in HEK293T cells after 30 mins by luciferase reporter gene assay	B	4.8	pIC50	16000	nM	IC50	J Med Chem (2014) 57: 7900-7915 [PMID:25101911]
GtoPdb	-	-	5.52	pIC50	3000	nM	IC50	J Med Chem (2014) 57: 7900-15 [PMID:25101911]
ChEMBL	Inhibition of purified human ALK5 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P]	B	5.52	pIC50	3000	nM	IC50	J Med Chem (2014) 57: 7900-7915 [PMID:25101911]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]