1-deoxynojirimycin [Ligand Id: 4642] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL307429 (Deoxynojirimycin, Duvoglustat)
  • glucosidase alpha, acid in Human [GtoPdb: 2611] [UniProtKB: P10253]
  • glucosidase alpha, acid/Acidic alpha-glucosidase in Rat [ChEMBL: CHEMBL3513] [GtoPdb: 2611] [UniProtKB: Q6P7A9]
  • This target only has 1 pki data point
1 CHEMBL307429_lig_chart_1 glucosidase alpha, acid HumanRat
There should be some charts here, you may need to enable JavaScript!
  • Alpha-galactosidase in Coffea arabica [ChEMBL: CHEMBL5217] [UniProtKB: Q42656]
  • This target only has 0 pki data point
2 CHEMBL307429_lig_chart_2 Alpha-galactosidase Coffea arabica
There should be some charts here, you may need to enable JavaScript!
  • Alpha-galactosidase A in Human [ChEMBL: CHEMBL2524] [UniProtKB: P06280]
  • This target only has 1 pki data point
3 CHEMBL307429_lig_chart_3 Alpha-galactosidase A Human
There should be some charts here, you may need to enable JavaScript!
  • Alpha-glucosidase in Geobacillus stearothermophilus [ChEMBL: CHEMBL4412] [UniProtKB: P94451]
  • Alpha-glucosidase in Bovine [ChEMBL: CHEMBL2974] [UniProtKB: Q9MYM4]
  • Alpha-glucosidase in Oryza sativa Japonica Group [ChEMBL: CHEMBL5280] [UniProtKB: Q9LGC6]
  • This target only has 0 pki data point
4 CHEMBL307429_lig_chart_4 Alpha-glucosidase Geobacillus stearothermophilusBovineOryza sativa Japonica Group
There should be some charts here, you may need to enable JavaScript!
  • Alpha-L-fucosidase I in Human [ChEMBL: CHEMBL4176] [UniProtKB: P04066]
  • This target only has 0 pki data point
5 CHEMBL307429_lig_chart_5 Alpha-L-fucosidase I Human
There should be some charts here, you may need to enable JavaScript!
  • Alpha-mannosidase 2C1 in Rat [ChEMBL: CHEMBL2852] [UniProtKB: P21139]
  • This target only has 0 pki data point
6 CHEMBL307429_lig_chart_6 Alpha-mannosidase 2C1 Rat
There should be some charts here, you may need to enable JavaScript!
  • Beta-galactosidase in Rat [ChEMBL: CHEMBL2680] [UniProtKB: D3ZUM4]
  • This target only has 0 pki data point
7 CHEMBL307429_lig_chart_7 Beta-galactosidase Rat
There should be some charts here, you may need to enable JavaScript!
  • glucosylceramidase beta/Beta-glucocerebrosidase in Human [ChEMBL: CHEMBL2179] [GtoPdb: 2978] [UniProtKB: P04062]
8 CHEMBL307429_lig_chart_8 Beta-glucocerebrosidase Human
There should be some charts here, you may need to enable JavaScript!
9 CHEMBL307429_lig_chart_9 Beta-glucosidase Agrobacterium tumefaciensHumanPrunus avium
There should be some charts here, you may need to enable JavaScript!
  • Beta-glucosidase A in Caldicellulosiruptor saccharolyticus [ChEMBL: CHEMBL4622] [UniProtKB: P10482]
  • This target only has 0 pki data point
10 CHEMBL307429_lig_chart_10 Beta-glucosidase A Caldicellulosiruptor saccharolyticus
There should be some charts here, you may need to enable JavaScript!
  • Beta-glucosidase cytosolic in Human [ChEMBL: CHEMBL3865] [UniProtKB: Q9H227]
  • This target only has 0 pki data point
11 CHEMBL307429_lig_chart_11 Beta-glucosidase cytosolic Human
There should be some charts here, you may need to enable JavaScript!
  • UDP-glucose ceramide glucosyltransferase/Ceramide glucosyltransferase in Human [ChEMBL: CHEMBL2063] [GtoPdb: 2528] [UniProtKB: Q16739]
  • This target only has 0 pki data point
12 CHEMBL307429_lig_chart_12 Ceramide glucosyltransferase Human
There should be some charts here, you may need to enable JavaScript!
  • Glycogen debranching enzyme in Human [ChEMBL: CHEMBL5272] [UniProtKB: P35573]
  • Glycogen debranching enzyme in Rabbit [ChEMBL: CHEMBL5273] [UniProtKB: P35574]
  • This target only has 0 pki data point
13 CHEMBL307429_lig_chart_13 Glycogen debranching enzyme HumanRabbit
There should be some charts here, you may need to enable JavaScript!
  • Lactase-glycosylceramidase in Rat [ChEMBL: CHEMBL3389] [UniProtKB: Q02401]
  • This target only has 0 pki data point
14 CHEMBL307429_lig_chart_14 Lactase-glycosylceramidase Rat
There should be some charts here, you may need to enable JavaScript!
  • Lactase-phlorizin hydrolase in Human [ChEMBL: CHEMBL1075131] [UniProtKB: P09848]
  • This target only has 0 pki data point
15 CHEMBL307429_lig_chart_15 Lactase-phlorizin hydrolase Human
There should be some charts here, you may need to enable JavaScript!
  • Liver X receptor-α/LXR-alpha in Human [ChEMBL: CHEMBL2808] [GtoPdb: 602] [UniProtKB: Q13133]
  • This target only has 0 pki data point
16 CHEMBL307429_lig_chart_16 LXR-alpha Human
There should be some charts here, you may need to enable JavaScript!
  • Liver X receptor-β/LXR-beta in Human [ChEMBL: CHEMBL4093] [GtoPdb: 601] [UniProtKB: P55055]
  • This target only has 0 pki data point
17 CHEMBL307429_lig_chart_17 LXR-beta Human
There should be some charts here, you may need to enable JavaScript!
  • glucosidase alpha, acid/Lysosomal alpha-glucosidase in Human [ChEMBL: CHEMBL2608] [GtoPdb: 2611] [UniProtKB: P10253]
  • glucosidase alpha, acid/Lysosomal alpha-glucosidase in Mouse [ChEMBL: CHEMBL1667668] [GtoPdb: 2611] [UniProtKB: P70699]
18 CHEMBL307429_lig_chart_18 Lysosomal alpha-glucosidase HumanMouse
There should be some charts here, you may need to enable JavaScript!
  • maltase-glucoamylase/Maltase-glucoamylase in Human [ChEMBL: CHEMBL2074] [GtoPdb: 2627] [UniProtKB: O43451]
  • This target only has 0 pki data point
19 CHEMBL307429_lig_chart_19 Maltase-glucoamylase Human
There should be some charts here, you may need to enable JavaScript!
  • Mannosidase 2 alpha 1 in Rat [ChEMBL: CHEMBL2257] [UniProtKB: P28494]
  • This target only has 1 pki data point
20 CHEMBL307429_lig_chart_20 Mannosidase 2 alpha 1 Rat
There should be some charts here, you may need to enable JavaScript!
  • Neutral alpha-glucosidase AB in Human [ChEMBL: CHEMBL2519] [UniProtKB: Q14697]
21 CHEMBL307429_lig_chart_21 Neutral alpha-glucosidase AB Human
There should be some charts here, you may need to enable JavaScript!
  • Neutral alpha-glucosidase C in Mouse [ChEMBL: CHEMBL3635] [UniProtKB: Q8BVW0]
  • This target only has 0 pki data point
22 CHEMBL307429_lig_chart_22 Neutral alpha-glucosidase C Mouse
There should be some charts here, you may need to enable JavaScript!
  • Sucrase-isomaltase in Human [ChEMBL: CHEMBL2748] [UniProtKB: P14410]
  • Sucrase-isomaltase in Rat [ChEMBL: CHEMBL3114] [UniProtKB: P23739]
  • This target only has 1 pki data point
23 CHEMBL307429_lig_chart_23 Sucrase-isomaltase HumanRat
There should be some charts here, you may need to enable JavaScript!
24 CHEMBL307429_lig_chart_24 Trehalase HumanRat
There should be some charts here, you may need to enable JavaScript!
  • Uncharacterized protein in Pig [ChEMBL: CHEMBL2176863] [UniProtKB: I3LIR5]
  • This target only has 0 pki data point
25 CHEMBL307429_lig_chart_25 Uncharacterized protein Pig
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
glucosidase alpha, acid in Human [GtoPdb: 2611] [UniProtKB: P10253]
GtoPdb - - 6.82 pKi 150 nM Ki Bioorg. Med. Chem. Lett. (1997) 7: 355-360
glucosidase alpha, acid/Acidic alpha-glucosidase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3513] [GtoPdb: 2611] [UniProtKB: Q6P7A9]
ChEMBL Concentration that causes 50% inhibition of mammalian alpha-glucosidase (lysosomal) was determined in rat liver B 4.6 pIC50 25000 nM IC50 J. Med. Chem. (1994) 37: 3701-3706 [PMID:7966130]
ChEMBL Inhibition of rat liver lysosome alpha-glucosidase assessed as D-glucose release after 30 mins by Glucose B-test B 6.4 pIC50 400 nM IC50 J. Nat. Prod. (2002) 65: 1875-1881 [PMID:12502331]
ChEMBL Concentration that causes 50% inhibition of mammalian alpha-glucosidase (lysosomal) was determined in rat liver B 6.4 pIC50 400 nM IC50 J. Med. Chem. (1994) 37: 3701-3706 [PMID:7966130]
ChEMBL Inhibition of rat intestinal maltase assessed as D-glucose release after 30 mins by Glucose B-test B 6.44 pIC50 360 nM IC50 J. Nat. Prod. (2002) 65: 1875-1881 [PMID:12502331]
ChEMBL Concentration that causes 50% inhibition of mammalian alpha-glucosidase (maltase) was determined in rat intestine B 6.44 pIC50 360 nM IC50 J. Med. Chem. (1994) 37: 3701-3706 [PMID:7966130]
ChEMBL Inhibition of rat intestinal maltase using moltose as substrate B 6.44 pIC50 360 nM IC50 J. Med. Chem. (2012) 55: 10347-10362 [PMID:23106358]
ChEMBL Inhibition of rat intestinal brush border membrane maltase B 6.89 pIC50 130 nM IC50 Bioorg. Med. Chem. (2008) 16: 7330-7336 [PMID:18595718]
Alpha-galactosidase in Coffea arabica (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5217] [UniProtKB: Q42656]
ChEMBL Inhibition of alpha-galactosidase in green coffee bean after 30 mins by spectrophotometric analysis B 4.64 pIC50 23000 nM IC50 MedChemComm (2013) 4: 387-393
Alpha-galactosidase A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2524] [UniProtKB: P06280]
ChEMBL Compound tested for inhibition of alpha-galactosidase from Aspergillus niger B 4.74 pKi 18000 nM Ki Bioorg. Med. Chem. Lett. (2004) 14: 73-75 [PMID:14684301]
Alpha-glucosidase in Geobacillus stearothermophilus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4412] [UniProtKB: P94451]
ChEMBL Inhibition of alpha glucosidase from bacillus stearothermophilus B 5.78 pIC50 1670 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 954-958 [PMID:18166456]
Alpha-glucosidase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2974] [UniProtKB: Q9MYM4]
ChEMBL Inhibition of mammalian alpha-glucosidase (lysosomal) was determined in bovine liver B 4.68 pIC50 21000 nM IC50 J. Med. Chem. (1994) 37: 3701-3706 [PMID:7966130]
ChEMBL Inhibition of mammalian alpha-glucosidase (lysosomal) was determined in bovine liver B 6.4 pIC50 400 nM IC50 J. Med. Chem. (1994) 37: 3701-3706 [PMID:7966130]
Alpha-glucosidase in Oryza sativa Japonica Group (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5280] [UniProtKB: Q9LGC6]
ChEMBL Inhibitory activity against alpha-Glucosidase from rice B 7.3 pIC50 50 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 5991-5995 [PMID:15546715]
ChEMBL Inhibitory concentration against rice alpha-glucosidase B 7.52 pIC50 30 nM IC50 J. Med. Chem. (2005) 48: 2036-2044 [PMID:15771446]
Alpha-L-fucosidase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4176] [UniProtKB: P04066]
ChEMBL Concentration that causes 50% inhibition of mammalian alpha-L-fucosidase was determined in bovine epididymis B 4.59 pIC50 26000 nM IC50 J. Med. Chem. (1994) 37: 3701-3706 [PMID:7966130]
Alpha-mannosidase 2C1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2852] [UniProtKB: P21139]
ChEMBL Inhibition of soluble Alpha-mannosidase II in rat liver B 4.3 pIC50 <50000 nM IC50 J. Med. Chem. (1995) 38: 2349-2356 [PMID:7608901]
Beta-galactosidase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2680] [UniProtKB: D3ZUM4]
ChEMBL Concentration that causes 50% inhibition of mammalian lactase beta-galactosidase was determined in rat intestine B 4.52 pIC50 30000 nM IC50 J. Med. Chem. (1994) 37: 3701-3706 [PMID:7966130]
ChEMBL Concentration that causes 50% inhibition of mammalian beta-galactosidase (lactase ) was determined in rat intestine B 4.57 pIC50 27000 nM IC50 J. Med. Chem. (1994) 37: 3701-3706 [PMID:7966130]
glucosylceramidase beta/Beta-glucocerebrosidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2179] [GtoPdb: 2978] [UniProtKB: P04062]
ChEMBL Inhibition of human lysosomal beta-glucocerebrosidase B 4.1 pKi 79000 nM Ki Bioorg. Med. Chem. Lett. (2014) 24: 2777-2780 [PMID:24803362]
ChEMBL Inhibitory activity against beta-glucosidase of sweet almond B 4.33 pKi 47000 nM Ki Bioorg. Med. Chem. Lett. (1999) 9: 615-618 [PMID:10098675]
ChEMBL Competitive Inhibition constant on Asp. Wentii beta Glucosidase at pH 5.0 B 5.7 pKi 2000 nM Ki Bioorg. Med. Chem. Lett. (1992) 2: 27-32
Beta-glucosidase in Agrobacterium tumefaciens (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4663] [UniProtKB: P27034]
ChEMBL Inhibition of Agrobacterium sp. beta-glucosidase B 4.92 pKi 12000 nM Ki Bioorg. Med. Chem. Lett. (2006) 16: 2067-2070 [PMID:16481162]
ChEMBL Inhibition of Agrobacterium sp. beta glucosidase B 4.92 pKi 12000 nM Ki Bioorg. Med. Chem. Lett. (2014) 24: 2777-2780 [PMID:24803362]
Beta-glucosidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3761] [UniProtKB: Q9HCG7]
ChEMBL Inhibition of non-lysosomal glucosylceramidase B 4.52 pIC50 30000 nM IC50 Eur. J. Med. Chem. (2011) 46: 1949-1963 [PMID:21354674]
ChEMBL Displacement of 4-methylumbelliferyl from non-lysosomal GBA2 by fluorimetry B 4.54 pIC50 28800 nM IC50 Bioorg. Med. Chem. (2010) 18: 267-273 [PMID:19931460]
ChEMBL Inhibition of GBA2 by HPLC B 4.68 pIC50 21000 nM IC50 J. Med. Chem. (2010) 53: 689-698 [PMID:20000679]
ChEMBL Inhibition of human GBA2 B 4.7 pIC50 20000 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 6600-6603 [PMID:19853441]
Beta-glucosidase in Prunus avium (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4192] [UniProtKB: Q43014]
ChEMBL Inhibitory activity against sweet almond Beta-glucosidase B 5.02 pKi 9500 nM Ki Bioorg. Med. Chem. Lett. (1991) 1: 667-672
ChEMBL Inhibitory activity against beta-Glucosidase from sweet almond B 4.09 pIC50 81000 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 5991-5995 [PMID:15546715]
Beta-glucosidase A in Caldicellulosiruptor saccharolyticus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4622] [UniProtKB: P10482]
ChEMBL Inhibition of Caldocellum saccharolyticum beta-glucosidase assessed as D-glucose release after 30 mins by Glucose B-test B 4 pIC50 100000 nM IC50 J. Nat. Prod. (2002) 65: 1875-1881 [PMID:12502331]
ChEMBL Inhibitory activity against beta-Glucosidase from Caldocellum saccharolyticum B 4.26 pIC50 55000 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 5991-5995 [PMID:15546715]
Beta-glucosidase cytosolic in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3865] [UniProtKB: Q9H227]
ChEMBL Inhibitory concentration against beta-glucosidase B 4.1 pIC50 80000 nM IC50 J. Med. Chem. (2005) 48: 2036-2044 [PMID:15771446]
UDP-glucose ceramide glucosyltransferase/Ceramide glucosyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2063] [GtoPdb: 2528] [UniProtKB: Q16739]
ChEMBL Inhibition of GCS by cell-based assay B 4 pIC50 >100000 nM IC50 J. Med. Chem. (2010) 53: 689-698 [PMID:20000679]
Glycogen debranching enzyme in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5272] [UniProtKB: P35573]
ChEMBL Inhibition of glycogen glycogen de-branching enzyme by HPLC B 5 pIC50 10000 nM IC50 J. Med. Chem. (2010) 53: 689-698 [PMID:20000679]
Glycogen debranching enzyme in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5273] [UniProtKB: P35574]
ChEMBL Inhibition of rabbit muscle amylo-1,6-glucosidase B 6.72 pIC50 190 nM IC50 Bioorg. Med. Chem. (2008) 16: 7330-7336 [PMID:18595718]
Lactase-glycosylceramidase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3389] [UniProtKB: Q02401]
ChEMBL Inhibition of rat intestinal lactase assessed as production of p-nitrophenol by spectrophotometry B 4.31 pIC50 49000 nM IC50 Bioorg. Med. Chem. (2011) 19: 3558-3568 [PMID:21546253]
ChEMBL Inhibition of Glycosidases (lactase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method B 4.47 pIC50 34000 nM IC50 J. Med. Chem. (1995) 38: 2349-2356 [PMID:7608901]
ChEMBL Concentration that causes 50% inhibition of mammalian lactase beta-galactosidase was determined in rat intestine B 4.59 pIC50 26000 nM IC50 J. Med. Chem. (1994) 37: 3701-3706 [PMID:7966130]
ChEMBL Inhibition of rat intestinal lactase using lactose as substrate B 4.59 pIC50 26000 nM IC50 J. Med. Chem. (2012) 55: 10347-10362 [PMID:23106358]
Lactase-phlorizin hydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075131] [UniProtKB: P09848]
ChEMBL Inhibition of lactase by HPLC B 4.21 pIC50 62000 nM IC50 J. Med. Chem. (2010) 53: 689-698 [PMID:20000679]
Liver X receptor-α/LXR-alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2808] [GtoPdb: 602] [UniProtKB: Q13133]
ChEMBL Antagonist activity at human recombinant LXRalpha expressed in HEK293 cells by luciferase reporter gene assay F 4 pIC50 >100000 nM IC50 Bioorg. Med. Chem. (2008) 16: 4272-4285 [PMID:18343126]
Liver X receptor-β/LXR-beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4093] [GtoPdb: 601] [UniProtKB: P55055]
ChEMBL Antagonist activity at human recombinant LXRbeta expressed in HEK293 cells by luciferase reporter gene assay F 4 pIC50 >100000 nM IC50 Bioorg. Med. Chem. (2008) 16: 4272-4285 [PMID:18343126]
glucosidase alpha, acid/Lysosomal alpha-glucosidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2608] [GtoPdb: 2611] [UniProtKB: P10253]
ChEMBL Inhibitory activity against alpha-glucosidase of yeast B 4.6 pKi 25000 nM Ki Bioorg. Med. Chem. Lett. (1999) 9: 615-618 [PMID:10098675]
GtoPdb - - 6.82 pKi 150 nM Ki Bioorg. Med. Chem. Lett. (1997) 7: 355-360
ChEMBL Tested in vitro for the inhibition constant against human lysosomal alpha-glucosidase B 6.82 pKi 150 nM Ki Bioorg. Med. Chem. Lett. (1997) 7: 355-360
ChEMBL Inhibitory activity was determined against baker's yeast Alpha-Glucosidase B 4.04 pIC50 91900 nM IC50 Bioorg. Med. Chem. Lett. (1994) 4: 2643-2648
ChEMBL Inhibition of human lysosomal alpha glucosidase B 5.82 pIC50 1500 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 6600-6603 [PMID:19853441]
ChEMBL Inhibition of lysosomal alpha-glucosidase by HPLC B 5.82 pIC50 1500 nM IC50 J. Med. Chem. (2010) 53: 689-698 [PMID:20000679]
ChEMBL Inhibition of human lysosomal alpha-glucosidase B 6 pIC50 1000 nM IC50 Bioorg. Med. Chem. (2008) 16: 7330-7336 [PMID:18595718]
ChEMBL Inhibition of maltase in human Caco-2 cell model system after 2 hrs B 7.22 pIC50 60 nM IC50 Bioorg. Med. Chem. (2008) 16: 7330-7336 [PMID:18595718]
glucosidase alpha, acid/Lysosomal alpha-glucosidase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1667668] [GtoPdb: 2611] [UniProtKB: P70699]
ChEMBL Enzyme Activity Assay: Cells were washed two times with 200 μL dPBS followed by the addition of 70 μL of substrate (2.11 mM 3 mM 4-MU-α-D-glu) in citrate-phosphate buffer (30 mM sodium citrate, 40 mM sodium phosphate dibasic, pH 4.0), and 2.5% DMSO to rows 1-12. Following incubation at 37° C. with 5% CO2 for about 3 h, 70 μL of stop buffer (0.4 M glycine pH 10.8) was added to rows 1-12. The plate was read in a Victor2 multilabel counter-Wallac fluorescent plate reader and the fluorescence at F460 nm was determined b at an excitation of 355 nm and emission of 460 nm using 1 second read time per well. Enzyme activity per μg of protein in the supernatant was calculated from the amount of fluorescence emitted, which is directly proportional to the amount of substrate hydrolyzed, and hence, the amount of Gaa activity in the lysate. B 4.01 pEC50 98800 nM EC50 US-9181184-B2. Method for the treatment of pompe disease using 1-deoxynojirimycin and derivatives (2015)
maltase-glucoamylase/Maltase-glucoamylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2074] [GtoPdb: 2627] [UniProtKB: O43451]
ChEMBL Inhibition of maltase by HPLC B 5.7 pIC50 2000 nM IC50 J. Med. Chem. (2010) 53: 689-698 [PMID:20000679]
ChEMBL Inhibition of Glycosidases (maltase) in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method B 6.44 pIC50 360 nM IC50 J. Med. Chem. (1995) 38: 2349-2356 [PMID:7608901]
ChEMBL Inhibitory concentration against human alpha-glucosidase B 7.4 pIC50 40 nM IC50 J. Med. Chem. (2005) 48: 2036-2044 [PMID:15771446]
Mannosidase 2 alpha 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2257] [UniProtKB: P28494]
ChEMBL Competitive Inhibitory activity against Golgi Alpha-mannosidase II B 4.3 pKi <50000 nM Ki J. Med. Chem. (1995) 38: 2349-2356 [PMID:7608901]
ChEMBL Inhibition of golgi Alpha-mannosidase II in rat liver B 4.3 pIC50 <50000 nM IC50 J. Med. Chem. (1995) 38: 2349-2356 [PMID:7608901]
Neutral alpha-glucosidase AB in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2519] [UniProtKB: Q14697]
ChEMBL Competitive Inhibition constant on yeast alpha Glucosidase at pH 6.0 B 4.64 pKi 23000 nM Ki Bioorg. Med. Chem. Lett. (1992) 2: 27-32
ChEMBL Competitive Inhibition constant on yeast alpha Glucosidase at pH 7.0 B 4.68 pKi 21000 nM Ki Bioorg. Med. Chem. Lett. (1992) 2: 27-32
ChEMBL Competitive Inhibition constant on rice alpha Glucosidase at pH 5.0 B 6.8 pKi 160 nM Ki Bioorg. Med. Chem. Lett. (1992) 2: 27-32
ChEMBL Competitive Inhibition constant on rice alpha Glucosidase at pH 6.0 B 7.85 pKi 14 nM Ki Bioorg. Med. Chem. Lett. (1992) 2: 27-32
ChEMBL Concentration that causes 50% inhibition of mammalian alpha-mannosidase (Golgi I) was determined in rat liver B 4.6 pIC50 25000 nM IC50 J. Med. Chem. (1994) 37: 3701-3706 [PMID:7966130]
ChEMBL Tested for competitive inhibition of endoplasmic reticulum alpha-glucosidase II. B 5.89 pIC50 1300 nM IC50 J. Med. Chem. (1994) 37: 3701-3706 [PMID:7966130]
Neutral alpha-glucosidase C in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3635] [UniProtKB: Q8BVW0]
ChEMBL Concentration that causes 50% inhibition of mammalian alpha-glucosidase (isomaltase) was determined in rat intestine B 4.47 pIC50 34000 nM IC50 J. Med. Chem. (1994) 37: 3701-3706 [PMID:7966130]
ChEMBL Concentration that causes 50% inhibition of mammalian alpha-glucosidase (isomaltase) was determined in rat intestine B 6.52 pIC50 300 nM IC50 J. Med. Chem. (1994) 37: 3701-3706 [PMID:7966130]
Sucrase-isomaltase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2748] [UniProtKB: P14410]
ChEMBL Inhibition of sucrase by HPLC B 5.7 pIC50 2000 nM IC50 J. Med. Chem. (2010) 53: 689-698 [PMID:20000679]
Sucrase-isomaltase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3114] [UniProtKB: P23739]
ChEMBL Tested in vitro for the inhibition constant against rat small intestinal sucrase B 7.62 pKi 24 nM