1-deoxynojirimycin [Ligand Id: 4642] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL307429 (1,5-dideoxy-1,5-imino-, 1,5-dideoxy-1,5-imino-d-glucitol, 1 deoxynojirimycin, 1-deoxynojirimycin, Bay-h-5595, D-1-deoxynojirimycin, Deoxynojirimycin, Duvoglustat, Moranolin, Moranoline, Nojirimycin, 1-deoxy-) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| alpha glucosidase in Human [GtoPdb: 2611] [UniProtKB: P10253] | ||||||||
| GtoPdb | - | - | 6.82 | pKi | 150 | nM | Ki | Bioorg Med Chem Lett (1997) 7: 355-360 |
| alpha glucosidase/Acidic alpha-glucosidase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3513] [GtoPdb: 2611] [UniProtKB: Q6P7A9] | ||||||||
| ChEMBL | Concentration that causes 50% inhibition of mammalian alpha-glucosidase (lysosomal) was determined in rat liver | B | 4.6 | pIC50 | 25000 | nM | IC50 | J Med Chem (1994) 37: 3701-3706 [PMID:7966130] |
| ChEMBL | Inhibition of rat liver lysosome alpha-glucosidase assessed as D-glucose release after 30 mins by Glucose B-test | B | 6.4 | pIC50 | 400 | nM | IC50 | J Nat Prod (2002) 65: 1875-1881 [PMID:12502331] |
| ChEMBL | Concentration that causes 50% inhibition of mammalian alpha-glucosidase (lysosomal) was determined in rat liver | B | 6.4 | pIC50 | 400 | nM | IC50 | J Med Chem (1994) 37: 3701-3706 [PMID:7966130] |
| ChEMBL | Inhibition of rat intestinal maltase assessed as D-glucose release after 30 mins by Glucose B-test | B | 6.44 | pIC50 | 360 | nM | IC50 | J Nat Prod (2002) 65: 1875-1881 [PMID:12502331] |
| ChEMBL | Concentration that causes 50% inhibition of mammalian alpha-glucosidase (maltase) was determined in rat intestine | B | 6.44 | pIC50 | 360 | nM | IC50 | J Med Chem (1994) 37: 3701-3706 [PMID:7966130] |
| ChEMBL | Inhibition of rat intestinal maltase using moltose as substrate | B | 6.44 | pIC50 | 360 | nM | IC50 | J Med Chem (2012) 55: 10347-10362 [PMID:23106358] |
| ChEMBL | Inhibition of rat intestinal brush border membrane maltase | B | 6.89 | pIC50 | 130 | nM | IC50 | Bioorg Med Chem (2008) 16: 7330-7336 [PMID:18595718] |
| Alpha-galactosidase in Coffea arabica (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5217] [UniProtKB: Q42656] | ||||||||
| ChEMBL | Inhibition of alpha-galactosidase in green coffee bean after 30 mins by spectrophotometric analysis | B | 4.64 | pIC50 | 23000 | nM | IC50 | Medchemcomm (2013) 4: 387-393 |
| Alpha-galactosidase A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2524] [UniProtKB: P06280] | ||||||||
| ChEMBL | Compound tested for inhibition of alpha-galactosidase from Aspergillus niger | B | 4.74 | pKi | 18000 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 73-75 [PMID:14684301] |
| Alpha-glucosidase in Geobacillus stearothermophilus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4412] [UniProtKB: P94451] | ||||||||
| ChEMBL | Inhibition of alpha glucosidase from bacillus stearothermophilus | B | 5.78 | pIC50 | 1670 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 954-958 [PMID:18166456] |
| Alpha-glucosidase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2974] [UniProtKB: Q9MYM4] | ||||||||
| ChEMBL | Inhibition of mammalian alpha-glucosidase (lysosomal) was determined in bovine liver | B | 4.68 | pIC50 | 21000 | nM | IC50 | J Med Chem (1994) 37: 3701-3706 [PMID:7966130] |
| ChEMBL | Inhibition of mammalian alpha-glucosidase (lysosomal) was determined in bovine liver | B | 6.4 | pIC50 | 400 | nM | IC50 | J Med Chem (1994) 37: 3701-3706 [PMID:7966130] |
| Alpha-glucosidase in Oryza sativa Japonica Group (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5280] [UniProtKB: Q9LGC6] | ||||||||
| ChEMBL | Inhibitory activity against alpha-Glucosidase from rice | B | 7.3 | pIC50 | 50 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 5991-5995 [PMID:15546715] |
| ChEMBL | Inhibitory concentration against rice alpha-glucosidase | B | 7.52 | pIC50 | 30 | nM | IC50 | J Med Chem (2005) 48: 2036-2044 [PMID:15771446] |
| Alpha-L-fucosidase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4176] [UniProtKB: P04066] | ||||||||
| ChEMBL | Concentration that causes 50% inhibition of mammalian alpha-L-fucosidase was determined in bovine epididymis | B | 4.59 | pIC50 | 26000 | nM | IC50 | J Med Chem (1994) 37: 3701-3706 [PMID:7966130] |
| Alpha-mannosidase 2C1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2852] [UniProtKB: P21139] | ||||||||
| ChEMBL | Inhibition of soluble Alpha-mannosidase II in rat liver | B | 4.3 | pIC50 | <50000 | nM | IC50 | J Med Chem (1995) 38: 2349-2356 [PMID:7608901] |
| Beta-galactosidase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2680] [UniProtKB: D3ZUM4] | ||||||||
| ChEMBL | Concentration that causes 50% inhibition of mammalian lactase beta-galactosidase was determined in rat intestine | B | 4.52 | pIC50 | 30000 | nM | IC50 | J Med Chem (1994) 37: 3701-3706 [PMID:7966130] |
| ChEMBL | Concentration that causes 50% inhibition of mammalian beta-galactosidase (lactase ) was determined in rat intestine | B | 4.57 | pIC50 | 27000 | nM | IC50 | J Med Chem (1994) 37: 3701-3706 [PMID:7966130] |
| glucosylceramidase beta/Beta-glucocerebrosidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2179] [GtoPdb: 2978] [UniProtKB: P04062] | ||||||||
| ChEMBL | Inhibition of human lysosomal beta-glucocerebrosidase | B | 4.1 | pKi | 79000 | nM | Ki | Bioorg Med Chem Lett (2014) 24: 2777-2780 [PMID:24803362] |
| ChEMBL | Inhibitory activity against beta-glucosidase of sweet almond | B | 4.33 | pKi | 47000 | nM | Ki | Bioorg Med Chem Lett (1999) 9: 615-618 [PMID:10098675] |
| ChEMBL | Competitive Inhibition constant on Asp. Wentii beta Glucosidase at pH 5.0 | B | 5.7 | pKi | 2000 | nM | Ki | Bioorg Med Chem Lett (1992) 2: 27-32 |
| Beta-glucosidase in Agrobacterium tumefaciens (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4663] [UniProtKB: P27034] | ||||||||
| ChEMBL | Inhibition of Agrobacterium sp. beta-glucosidase | B | 4.92 | pKi | 12000 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2067-2070 [PMID:16481162] |
| ChEMBL | Inhibition of Agrobacterium sp. beta glucosidase | B | 4.92 | pKi | 12000 | nM | Ki | Bioorg Med Chem Lett (2014) 24: 2777-2780 [PMID:24803362] |
| Beta-glucosidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3761] [UniProtKB: Q9HCG7] | ||||||||
| ChEMBL | Inhibition of non-lysosomal glucosylceramidase | B | 4.52 | pIC50 | 30000 | nM | IC50 | Eur J Med Chem (2011) 46: 1949-1963 [PMID:21354674] |
| ChEMBL | Displacement of 4-methylumbelliferyl from non-lysosomal GBA2 by fluorimetry | B | 4.54 | pIC50 | 28800 | nM | IC50 | Bioorg Med Chem (2010) 18: 267-273 [PMID:19931460] |
| ChEMBL | Inhibition of GBA2 by HPLC | B | 4.68 | pIC50 | 21000 | nM | IC50 | J Med Chem (2010) 53: 689-698 [PMID:20000679] |
| ChEMBL | Inhibition of human GBA2 | B | 4.7 | pIC50 | 20000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 6600-6603 [PMID:19853441] |
| Beta-glucosidase in Prunus avium (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4192] [UniProtKB: Q43014] | ||||||||
| ChEMBL | Inhibitory activity against sweet almond Beta-glucosidase | B | 5.02 | pKi | 9500 | nM | Ki | Bioorg Med Chem Lett (1991) 1: 667-672 |
| ChEMBL | Inhibitory activity against beta-Glucosidase from sweet almond | B | 4.09 | pIC50 | 81000 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 5991-5995 [PMID:15546715] |
| Beta-glucosidase A in Caldicellulosiruptor saccharolyticus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4622] [UniProtKB: P10482] | ||||||||
| ChEMBL | Inhibition of Caldocellum saccharolyticum beta-glucosidase assessed as D-glucose release after 30 mins by Glucose B-test | B | 4 | pIC50 | 100000 | nM | IC50 | J Nat Prod (2002) 65: 1875-1881 [PMID:12502331] |
| ChEMBL | Inhibitory activity against beta-Glucosidase from Caldocellum saccharolyticum | B | 4.26 | pIC50 | 55000 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 5991-5995 [PMID:15546715] |
| Beta-glucosidase cytosolic in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3865] [UniProtKB: Q9H227] | ||||||||
| ChEMBL | Inhibitory concentration against beta-glucosidase | B | 4.1 | pIC50 | 80000 | nM | IC50 | J Med Chem (2005) 48: 2036-2044 [PMID:15771446] |
| UDP-glucose ceramide glucosyltransferase/Ceramide glucosyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2063] [GtoPdb: 2528] [UniProtKB: Q16739] | ||||||||
| ChEMBL | Inhibition of GCS by cell-based assay | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2010) 53: 689-698 [PMID:20000679] |
| Glycogen debranching enzyme in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5272] [UniProtKB: P35573] | ||||||||
| ChEMBL | Inhibition of glycogen glycogen de-branching enzyme by HPLC | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2010) 53: 689-698 [PMID:20000679] |
| Glycogen debranching enzyme in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5273] [UniProtKB: P35574] | ||||||||
| ChEMBL | Inhibition of rabbit muscle amylo-1,6-glucosidase | B | 6.72 | pIC50 | 190 | nM | IC50 | Bioorg Med Chem (2008) 16: 7330-7336 [PMID:18595718] |
| Lactase-glycosylceramidase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3389] [UniProtKB: Q02401] | ||||||||
| ChEMBL | Inhibition of rat intestinal lactase assessed as production of p-nitrophenol by spectrophotometry | B | 4.31 | pIC50 | 49000 | nM | IC50 | Bioorg Med Chem (2011) 19: 3558-3568 [PMID:21546253] |
| ChEMBL | Inhibition of Glycosidases (lactase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method | B | 4.47 | pIC50 | 34000 | nM | IC50 | J Med Chem (1995) 38: 2349-2356 [PMID:7608901] |
| ChEMBL | Concentration that causes 50% inhibition of mammalian lactase beta-galactosidase was determined in rat intestine | B | 4.59 | pIC50 | 26000 | nM | IC50 | J Med Chem (1994) 37: 3701-3706 [PMID:7966130] |
| ChEMBL | Inhibition of rat intestinal lactase using lactose as substrate | B | 4.59 | pIC50 | 26000 | nM | IC50 | J Med Chem (2012) 55: 10347-10362 [PMID:23106358] |
| Lactase-phlorizin hydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075131] [UniProtKB: P09848] | ||||||||
| ChEMBL | Inhibition of lactase by HPLC | B | 4.21 | pIC50 | 62000 | nM | IC50 | J Med Chem (2010) 53: 689-698 [PMID:20000679] |
| Liver X receptor-α/LXR-alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2808] [GtoPdb: 602] [UniProtKB: Q13133] | ||||||||
| ChEMBL | Antagonist activity at human recombinant LXRalpha expressed in HEK293 cells by luciferase reporter gene assay | F | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem (2008) 16: 4272-4285 [PMID:18343126] |
| Liver X receptor-β/LXR-beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4093] [GtoPdb: 601] [UniProtKB: P55055] | ||||||||
| ChEMBL | Antagonist activity at human recombinant LXRbeta expressed in HEK293 cells by luciferase reporter gene assay | F | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem (2008) 16: 4272-4285 [PMID:18343126] |
| alpha glucosidase/Lysosomal alpha-glucosidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2608] [GtoPdb: 2611] [UniProtKB: P10253] | ||||||||
| ChEMBL | Inhibitory activity against alpha-glucosidase of yeast | B | 4.6 | pKi | 25000 | nM | Ki | Bioorg Med Chem Lett (1999) 9: 615-618 [PMID:10098675] |
| GtoPdb | - | - | 6.82 | pKi | 150 | nM | Ki | Bioorg Med Chem Lett (1997) 7: 355-360 |
| ChEMBL | Tested in vitro for the inhibition constant against human lysosomal alpha-glucosidase | B | 6.82 | pKi | 150 | nM | Ki | Bioorg Med Chem Lett (1997) 7: 355-360 |
| ChEMBL | Inhibition of human GAA using 4-methylumbelliferyl-alpha-D-glucopyranoside as substrate preincubated for 45 min followed by substrate addition and measured after 30 min by fluorescence spectrophotometer analysis | B | 7.23 | pKi | 59 | nM | Ki | J Med Chem (2022) 65: 2329-2341 [PMID:35072486] |
| ChEMBL | Inhibitory activity was determined against baker's yeast Alpha-Glucosidase | B | 4.04 | pIC50 | 91900 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 2643-2648 |
| ChEMBL | Inhibition of human lysosomal alpha glucosidase | B | 5.82 | pIC50 | 1500 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 6600-6603 [PMID:19853441] |
| ChEMBL | Inhibition of lysosomal alpha-glucosidase by HPLC | B | 5.82 | pIC50 | 1500 | nM | IC50 | J Med Chem (2010) 53: 689-698 [PMID:20000679] |
| ChEMBL | Inhibition of human lysosomal alpha-glucosidase | B | 6 | pIC50 | 1000 | nM | IC50 | Bioorg Med Chem (2008) 16: 7330-7336 [PMID:18595718] |
| ChEMBL | Inhibition of maltase in human Caco-2 cell model system after 2 hrs | B | 7.22 | pIC50 | 60 | nM | IC50 | Bioorg Med Chem (2008) 16: 7330-7336 [PMID:18595718] |
| alpha glucosidase/Lysosomal alpha-glucosidase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1667668] [GtoPdb: 2611] [UniProtKB: P70699] | ||||||||
| ChEMBL | Enzyme Activity Assay: Cells were washed two times with 200 μL dPBS followed by the addition of 70 μL of substrate (2.11 mM 3 mM 4-MU-α-D-glu) in citrate-phosphate buffer (30 mM sodium citrate, 40 mM sodium phosphate dibasic, pH 4.0), and 2.5% DMSO to rows 1-12. Following incubation at 37° C. with 5% CO2 for about 3 h, 70 μL of stop buffer (0.4 M glycine pH 10.8) was added to rows 1-12. The plate was read in a Victor2 multilabel counter-Wallac fluorescent plate reader and the fluorescence at F460 nm was determined b at an excitation of 355 nm and emission of 460 nm using 1 second read time per well. Enzyme activity per μg of protein in the supernatant was calculated from the amount of fluorescence emitted, which is directly proportional to the amount of substrate hydrolyzed, and hence, the amount of Gaa activity in the lysate. | B | 4.01 | pEC50 | 98800 | nM | EC50 | US-9181184-B2. Method for the treatment of pompe disease using 1-deoxynojirimycin and derivatives (2015) |
| maltase-glucoamylase/Maltase-glucoamylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2074] [GtoPdb: 2627] [UniProtKB: O43451] | ||||||||
| ChEMBL | Inhibition of alpha-glucosidase (unknown origin) preincubated for 5 mins followed by addition of pNPG substrate and measured after 30 mins by spectrophotometric method | B | 5.1 | pIC50 | 8030 | nM | IC50 | J Nat Prod (2021) 84: 1534-1543 [PMID:33979163] |
| ChEMBL | Inhibition of maltase by HPLC | B | 5.7 | pIC50 | 2000 | nM | IC50 | J Med Chem (2010) 53: 689-698 [PMID:20000679] |
| ChEMBL | Inhibition of human alpha-glucosidase | B | 5.85 | pIC50 | 1400 | nM | IC50 | Eur J Med Chem (2021) 224: 113716-113716 [PMID:34340042] |
| ChEMBL | Inhibition of Glycosidases (maltase) in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method | B | 6.44 | pIC50 | 360 | nM | IC50 | J Med Chem (1995) 38: 2349-2356 [PMID:7608901] |
| ChEMBL | Inhibitory concentration against human alpha-glucosidase | B | 7.4 | pIC50 | 40 | nM | IC50 | J Med Chem (2005) 48: 2036-2044 [PMID:15771446] |
| Mannosidase 2 alpha 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2257] [UniProtKB: P28494] | ||||||||
| ChEMBL | Competitive Inhibitory activity against Golgi Alpha-mannosidase II | B | 4.3 | pKi | <50000 | nM | Ki | J Med Chem (1995) 38: 2349-2356 [PMID:7608901] |
| ChEMBL | Inhibition of golgi Alpha-mannosidase II in rat liver | B | 4.3 | pIC50 | <50000 | nM | IC50 | J Med Chem (1995) 38: 2349-2356 [PMID:7608901] |
| Neutral alpha-glucosidase AB in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2519] [UniProtKB: Q14697] | ||||||||
| ChEMBL | Competitive Inhibition constant on yeast alpha Glucosidase at pH 6.0 | B | 4.64 | pKi | 23000 | nM | Ki | Bioorg Med Chem Lett (1992) 2: 27-32 |
| ChEMBL | Competitive Inhibition constant on yeast alpha Glucosidase at pH 7.0 | B | 4.68 | pKi | 21000 | nM | Ki | Bioorg Med Chem Lett (1992) 2: 27-32 |
| ChEMBL | Competitive Inhibition constant on rice alpha Glucosidase at pH 5.0 | B | 6.8 | pKi | 160 | nM | Ki | Bioorg Med Chem Lett (1992) 2: 27-32 |
| ChEMBL | Competitive Inhibition constant on rice alpha Glucosidase at pH 6.0 | B | 7.85 | pKi | 14 | nM | Ki | Bioorg Med Chem Lett (1992) 2: 27-32 |
| ChEMBL | Concentration that causes 50% inhibition of mammalian alpha-mannosidase (Golgi I) was determined in rat liver | B | 4.6 | pIC50 | 25000 | nM | IC50 | J Med Chem (1994) 37: 3701-3706 [PMID:7966130] |
| ChEMBL | Tested for competitive inhibition of endoplasmic reticulum alpha-glucosidase II. | B | 5.89 | pIC50 | 1300 | nM | IC50 | J Med Chem (1994) 37: 3701-3706 [PMID:7966130] |
| Neutral alpha-glucosidase C in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3635] [UniProtKB: Q8BVW0] | ||||||||
| ChEMBL | Concentration that causes 50% inhibition of mammalian alpha-glucosidase (isomaltase) was determined in rat intestine | B | 4.47 | pIC50 | 34000 | nM | IC50 | J Med Chem (1994) 37: 3701-3706 [PMID:7966130] |
| ChEMBL | Concentration that causes 50% inhibition of mammalian alpha-glucosidase (isomaltase) was determined in rat intestine | B | 6.52 | pIC50 | 300 | nM | IC50 | J Med Chem (1994) 37: 3701-3706 [PMID:7966130] |
| Sucrase-isomaltase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2748] [UniProtKB: P14410] | ||||||||
| ChEMBL | Inhibition of sucrase by HPLC | B | 5.7 | pIC50 | 2000 | nM | IC50 | J Med Chem (2010) 53: 689-698 [PMID:20000679] |
| Sucrase-isomaltase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3114] [UniProtKB: P23739] | ||||||||
| ChEMBL | Tested in vitro for the inhibition constant against rat small intestinal sucrase | B | 7.62 | pKi | 24 | nM | Ki | Bioorg Med Chem Lett (1997) 7: 355-360 |
| ChEMBL | Inhibition of rat intestinal isomaltase assessed as production of p-nitrophenol at by spectrophotometry | B | 6.19 | pIC50 | 650 | nM | IC50 | Bioorg Med Chem (2011) 19: 3558-3568 [PMID:21546253] |
| ChEMBL | Inhibitory concentration against rat intestinal maltase | B | 6.19 | pIC50 | 650 | nM | IC50 | J Med Chem (2005) 48: 2036-2044 [PMID:15771446] |
| ChEMBL | Inhibition of rat intestinal isomaltase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol measured by spectrometric assay | B | 6.21 | pIC50 | 610 | nM | IC50 | Eur J Med Chem (2021) 224: 113716-113716 [PMID:34340042] |
| ChEMBL | Inhibition of rat intestinal sucrase assessed as production of p-nitrophenol at by spectrophotometry | B | 6.29 | pIC50 | 510 | nM | IC50 | Bioorg Med Chem (2011) 19: 3558-3568 [PMID:21546253] |
| ChEMBL | Inhibitory activity against rat intestinal maltase using disaccharide | B | 6.44 | pIC50 | 360 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 5991-5995 [PMID:15546715] |
| ChEMBL | Inhibition of rat intestinal isomaltase using isomaltase as substrate | B | 6.52 | pIC50 | 300 | nM | IC50 | J Med Chem (2012) 55: 10347-10362 [PMID:23106358] |
| ChEMBL | Inhibition of Glycosidases (isomaltase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method | B | 6.52 | pIC50 | 300 | nM | IC50 | J Med Chem (1995) 38: 2349-2356 [PMID:7608901] |
| ChEMBL | Inhibitory activity against rat intestinal isomaltase using disaccharide | B | 6.52 | pIC50 | 300 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 5991-5995 [PMID:15546715] |
| ChEMBL | Inhibition of rat intestinal brush border membrane sucrase | B | 6.68 | pIC50 | 210 | nM | IC50 | Bioorg Med Chem (2008) 16: 7330-7336 [PMID:18595718] |
| ChEMBL | Inhibitory activity against rat intestinal sucrase using disaccharide | B | 6.68 | pIC50 | 210 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 5991-5995 [PMID:15546715] |
| ChEMBL | Inhibition of Sucrase in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method | B | 6.68 | pIC50 | 210 | nM | IC50 | J Med Chem (1995) 38: 2349-2356 [PMID:7608901] |
| ChEMBL | Inhibition of rat intestinal sucrase using sucrose as substrate | B | 6.68 | pIC50 | 210 | nM | IC50 | J Med Chem (2012) 55: 10347-10362 [PMID:23106358] |
| ChEMBL | Inhibition of rat intestinal sucrase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol measured by spectrometric assay | B | 6.72 | pIC50 | 190 | nM | IC50 | Eur J Med Chem (2021) 224: 113716-113716 [PMID:34340042] |
| ChEMBL | Inhibition of rat intestinal brush border membrane isomaltase | B | 6.8 | pIC50 | 160 | nM | IC50 | Bioorg Med Chem (2008) 16: 7330-7336 [PMID:18595718] |
| Trehalase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3087] [UniProtKB: O43280] | ||||||||
| ChEMBL | Inhibitory activity against trehalase from porcine kidney | B | 4.4 | pIC50 | 40000 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 5991-5995 [PMID:15546715] |
| Trehalase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3248] [UniProtKB: O70282] | ||||||||
| ChEMBL | Inhibition of Glycosidases (trehalase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method | B | 4.38 | pIC50 | 42000 | nM | IC50 | J Med Chem (1995) 38: 2349-2356 [PMID:7608901] |
| ChEMBL | Concentration that causes 50% inhibition of mammalian trehalase was determined in rat intestine | B | 4.38 | pIC50 | 42000 | nM | IC50 | J Med Chem (1994) 37: 3701-3706 [PMID:7966130] |
| ChEMBL | Inhibition of rat intestinal trehalase | B | 4.38 | pIC50 | 42000 | nM | IC50 | J Med Chem (2012) 55: 10347-10362 [PMID:23106358] |
| ChEMBL | Concentration that causes 50% inhibition of mammalian trehalase was determined in porcine kidney | B | 4.39 | pIC50 | 41000 | nM | IC50 | J Med Chem (1994) 37: 3701-3706 [PMID:7966130] |
| Uncharacterized protein in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2176863] [UniProtKB: I3LIR5] | ||||||||
| ChEMBL | Inhibition of pig kidney trehalase assessed as p-nitrophenol release by spectrophotometrically | B | 4.39 | pIC50 | 41000 | nM | IC50 | J Nat Prod (2002) 65: 198-202 [PMID:11858756] |
| ChEMBL | Inhibition of porcine kidney trehalase | B | 4.39 | pIC50 | 41000 | nM | IC50 | J Med Chem (2012) 55: 10347-10362 [PMID:23106358] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
