FGF-23   Click here for help

GtoPdb Ligand ID: 9291

Synonyms: fibroblast growth factor 23
Comment: FGF-23 regulates phosphate homeostasis and calcium transport in the kidney [3]. The full-length 327 amino acid protein is functional, and is deactivated by proteolytic cleavage which generates N-terminal and C-terminal chains. Mutation of the cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR), and other gene alterations are associated with hyperphosphatemic familial tumoral calcinosis (HFTC). Antibody-driven inactivation of FGF-23 is being investigated as a pharmacological intervention in these indications. Burosumab (KRN23) is one such FGF-23 neutralising antibody in clinical development.
A FGFR1 isoform [FGFR1(IIIc)] in complex with the Klotho protein (KL; Q9UEF7) forms a high affinity receptor for FGF-23 [1-2,4].
Species: Human
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Fibroblast growth factor (FGF) family ligands
Synonyms Click here for help
fibroblast growth factor 23
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
FGF23 fibroblast growth factor 23 Human fibroblast growth factor 23 precursor -
Database Links Click here for help
Ensembl Gene ENSG00000118972 (Hs)
Entrez Gene 8074 (Hs)
GtoPdb PubChem SID 318164810
Human Protein Atlas ENSG00000118972 (Hs)
UniProtKB Q9GZV9 (Hs)
Wikipedia Fibroblast_growth_factor_23