UK-356618 [Ligand Id: 6528] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL117225 (UK-356618) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| bone morphogenetic protein 1/Bone morphogenetic protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3898] [GtoPdb: 2333] [UniProtKB: P13497] | ||||||||
| ChEMBL | Inhibitory activity against Procollagen C-terminal proteinase (PCP) | B | 4.28 | pIC50 | 52000 | nM | IC50 | J Med Chem (2003) 46: 3514-3525 [PMID:12877590] |
| MMP1/Matrix metalloproteinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956] | ||||||||
| ChEMBL | Inhibition of Matrix metalloprotease-1 | B | 4.29 | pIC50 | 51000 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 571-574 [PMID:11229774] |
| ChEMBL | Inhibition of human Matrix metalloprotease-1 (MMP-1) | B | 4.29 | pIC50 | 51000 | nM | IC50 | J Med Chem (2003) 46: 3514-3525 [PMID:12877590] |
| ChEMBL | Inhibition of MMP1 | B | 4.29 | pIC50 | 51000 | nM | IC50 | Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648] |
| MMP13/Matrix metalloproteinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452] | ||||||||
| ChEMBL | Inhibition of Matrix metalloprotease-13 | B | 7.14 | pIC50 | 73 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 571-574 [PMID:11229774] |
| ChEMBL | Inhibition of Matrix metalloprotease-13 | B | 7.14 | pIC50 | 73 | nM | IC50 | J Med Chem (2003) 46: 3514-3525 [PMID:12877590] |
| ChEMBL | Inhibition of MMP13 | B | 7.14 | pIC50 | 73 | nM | IC50 | Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648] |
| MMP14/Matrix metalloproteinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281] | ||||||||
| ChEMBL | Inhibition of Matrix metalloprotease-14 | B | 5.72 | pIC50 | 1900 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 571-574 [PMID:11229774] |
| ChEMBL | Inhibition of Matrix metalloprotease-14 | B | 5.72 | pIC50 | 1900 | nM | IC50 | J Med Chem (2003) 46: 3514-3525 [PMID:12877590] |
| ChEMBL | Inhibition of MMP14 | B | 5.72 | pIC50 | 1900 | nM | IC50 | Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648] |
| MMP2/Matrix metalloproteinase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253] | ||||||||
| ChEMBL | Concentration required to inhibit the catalytic domain Matrix metalloprotease-2 using Nagase fluorogenic as a substrate. | B | 5.75 | pIC50 | 1790 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 571-574 [PMID:11229774] |
| ChEMBL | Inhibition of human matrix metalloprotease-2 (MMP-2) | B | 5.75 | pIC50 | 1790 | nM | IC50 | J Med Chem (2003) 46: 3514-3525 [PMID:12877590] |
| ChEMBL | Inhibition of MMP2 | B | 5.75 | pIC50 | 1790 | nM | IC50 | Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648] |
| MMP3/Matrix metalloproteinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254] | ||||||||
| GtoPdb | - | - | 8.2 | pIC50 | 5.9 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 571-4 [PMID:11229774] |
| ChEMBL | Concentration required to inhibit the catalytic domain Matrix metalloprotease-3 using Nagase fluorogenic as a substrate. | B | 8.23 | pIC50 | 5.9 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 571-574 [PMID:11229774] |
| ChEMBL | Inhibition of human matrix metalloprotease-3 (MMP-3) | B | 8.23 | pIC50 | 5.9 | nM | IC50 | J Med Chem (2003) 46: 3514-3525 [PMID:12877590] |
| ChEMBL | Inhibition of MMP3 | B | 8.23 | pIC50 | 5.9 | nM | IC50 | Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648] |
| ChEMBL | Inhibition of MMP3 | B | 8.23 | pIC50 | 5.89 | nM | IC50 | Bioorg Med Chem (2007) 15: 2223-2268 [PMID:17275314] |
| MMP9/Matrix metalloproteinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780] | ||||||||
| ChEMBL | Inhibition of Matrix metalloprotease-9 | B | 6.08 | pIC50 | 840 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 571-574 [PMID:11229774] |
| ChEMBL | Inhibition of human matrix metalloprotease-9 (MMP-9) | B | 6.08 | pIC50 | 840 | nM | IC50 | J Med Chem (2003) 46: 3514-3525 [PMID:12877590] |
| ChEMBL | Inhibition of MMP9 | B | 6.08 | pIC50 | 840 | nM | IC50 | Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
