MF 498 [Ligand Id: 5856] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL402162 |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| IP receptor/Prostacyclin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119] | ||||||||
| ChEMBL | Binding affinity to human IP receptor expressed in HEK293 cells | B | 5.15 | pKi | >7000 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2048-2054 [PMID:18291643] |
| DP1 receptor/Prostaglandin D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4427] [GtoPdb: 338] [UniProtKB: Q13258] | ||||||||
| ChEMBL | Binding affinity to human DP receptor expressed in HEK293 cells | B | 5.92 | pKi | 1200 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2048-2054 [PMID:18291643] |
| EP1 receptor/Prostaglandin E2 receptor EP1 subtype in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1811] [GtoPdb: 340] [UniProtKB: P34995] | ||||||||
| ChEMBL | Binding affinity to human EP1 receptor expressed in HEK293 cells | B | 5.15 | pKi | >7000 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2048-2054 [PMID:18291643] |
| EP2 receptor/Prostaglandin E2 receptor EP2 subtype in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1881] [GtoPdb: 341] [UniProtKB: P43116] | ||||||||
| ChEMBL | Binding affinity to human EP2 receptor expressed in HEK293 cells | B | 5.72 | pKi | 1900 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2048-2054 [PMID:18291643] |
| EP3 receptor/Prostaglandin E2 receptor EP3 subtype in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3710] [GtoPdb: 342] [UniProtKB: P43115] | ||||||||
| ChEMBL | Binding affinity to human EP3 receptor expressed in HEK293 cells | B | 5.4 | pKi | 4000 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2048-2054 [PMID:18291643] |
| EP4 receptor/Prostaglandin E2 receptor EP4 subtype in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1836] [GtoPdb: 343] [UniProtKB: P35408] | ||||||||
| ChEMBL | Binding affinity to human EP4 receptor expressed in HEK293 cells in presence of 10% human serum | B | 8.44 | pKi | 3.6 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2048-2054 [PMID:18291643] |
| ChEMBL | Binding affinity to human EP4 receptor expressed in HEK293 cells | B | 9.13 | pKi | 0.74 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2048-2054 [PMID:18291643] |
| GtoPdb | - | - | 9.15 | pKi | 0.7 | nM | Ki |
J Pharmacol Exp Ther (2008) 325: 425-34 [PMID:18287210]; Nat Commun (2024) 15: 4326 [PMID:38773113] |
| FP receptor/Prostaglandin F2-alpha receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1987] [GtoPdb: 344] [UniProtKB: P43088] | ||||||||
| ChEMBL | Binding affinity to human FP receptor expressed in HEK293 cells | B | 5.7 | pKi | 2000 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2048-2054 [PMID:18291643] |
| TP receptor/Thromboxane A2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069] [GtoPdb: 346] [UniProtKB: P21731] | ||||||||
| ChEMBL | Binding affinity to human TP receptor expressed in HEK293 cells | B | 6.2 | pKi | 630 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2048-2054 [PMID:18291643] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
