dexrazoxane   Click here for help

GtoPdb Ligand ID: 7330

Synonyms: ADR-529 | Cardioxane® | ICRF-187 | Savene® | Zinecard®
Approved drug
dexrazoxane is an approved drug (FDA (1995), EMA (2006))
Compound class: Synthetic organic
Comment: Dexrazoxane is an EDTA derivative with iron-chelating activity.
2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 105.8
Molecular weight 268.12
XLogP -1.3
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES OC1=NC(=O)CN(C1)CC(N1CC(=NC(=O)C1)O)C
Isomeric SMILES OC1=NC(=O)CN(C1)C[C@@H](N1CC(=NC(=O)C1)O)C
InChI InChI=1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)/t7-/m0/s1
InChI Key BMKDZUISNHGIBY-ZETCQYMHSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (1995), EMA (2006))
IUPAC Name Click here for help
6-hydroxy-4-[(2S)-2-(5-hydroxy-3-oxo-1,2,3,6-tetrahydropyrazin-1-yl)propyl]-2,3,4,5-tetrahydropyrazin-2-one
International Nonproprietary Names Click here for help
INN number INN
6544 dexrazoxane
Synonyms Click here for help
ADR-529 | Cardioxane® | ICRF-187 | Savene® | Zinecard®
Database Links Click here for help
CAS Registry No. 24584-09-6
ChEMBL Ligand CHEMBL1738
DrugBank Ligand DB00380
DrugCentral Ligand 839
GtoPdb PubChem SID 178103902
PubChem CID 71384
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Wikipedia Dexrazoxane