ChEMBL ligand: CHEMBL18701 (Ro-201724)
phosphodiesterase 4A/Phosphodiesterase 4A in Human [ChEMBL: CHEMBL254] [GtoPdb: 1300] [UniProtKB: P27815] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4B/Phosphodiesterase 4B in Human [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343] There should be some charts here, you may need to enable JavaScript!
TNF-alpha in Human [ChEMBL: CHEMBL1825] [UniProtKB: P01375] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4C in Human [GtoPdb: 1302] [UniProtKB: Q08493] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4D in Human [GtoPdb: 1303] [UniProtKB: Q08499] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
phosphodiesterase 4A/Phosphodiesterase 4A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL254] [GtoPdb: 1300] [UniProtKB: P27815]
ChEMBL	Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assay	B	5.37	pIC50	4300	nM	IC50	J Med Chem (2011) 54: 3331-3347 [PMID:21456625]
GtoPdb	-	-	6.5	pIC50	316	nM	IC50	Biochem Biophys Res Commun (1997) 234: 320-4 [PMID:9177268]
ChEMBL	Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into foci	B	5.48	pEC50	3300	nM	EC50	J Med Chem (2011) 54: 3331-3347 [PMID:21456625]
phosphodiesterase 4B/Phosphodiesterase 4B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343]
ChEMBL	Inhibition of human Phosphodiesterase 4B	B	5.71	pKi	1930	nM	Ki	J Med Chem (1995) 38: 4848-4854 [PMID:7490734]
GtoPdb	-	-	6.4	pIC50	398	nM	IC50	Biochem Biophys Res Commun (1997) 234: 320-4 [PMID:9177268]
TNF-alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1825] [UniProtKB: P01375]
ChEMBL	TNF-alpha production in PBMC by ELISA method	F	4.3	pIC50	50000	nM	IC50	J Med Chem (1996) 39: 2-9 [PMID:8568809]
phosphodiesterase 4C in Human [GtoPdb: 1302] [UniProtKB: Q08493]
GtoPdb	-	-	5.4	pIC50	3980	nM	IC50	Biochem Biophys Res Commun (1997) 234: 320-4 [PMID:9177268]
phosphodiesterase 4D in Human [GtoPdb: 1303] [UniProtKB: Q08499]
GtoPdb	-	-	6.2	pIC50	631	nM	IC50	Biochem Biophys Res Commun (1997) 234: 320-4 [PMID:9177268]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]