apalcillin   Click here for help

GtoPdb Ligand ID: 10759

Synonyms: PC-904 | PC904 | WY-44,417 | WY-44417
Compound class: Synthetic organic
Comment: Apalcillin (PC-904) is a semisynthetic penicillin (β-lactam) derivative antibiotic [1-2]. It is highly active against Pseudomonas species. Toxicity issues meant that this compound did not progress beyond preclinical evaluation.
2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 9
Hydrogen bond donors 4
Rotatable bonds 8
Topological polar surface area 186.86
Molecular weight 521.14
XLogP 0.66
No. Lipinski's rules broken 0
Click here for help
Canonical SMILES O=C([C@@H](c1ccccc1)NC(=O)c1c[nH]c2c(c1=O)nccc2)N[C@@H]1C(=O)N2[C@@H]1SC([C@@H]2C(=O)O)(C)C
Isomeric SMILES O=C([C@@H](c1ccccc1)NC(=O)c1c[nH]c2c(c1=O)nccc2)N[C@@H]1C(=O)N2[C@@H]1SC([C@@H]2C(=O)O)(C)C
InChI InChI=1S/C25H23N5O6S/c1-25(2)19(24(35)36)30-22(34)17(23(30)37-25)29-21(33)15(12-7-4-3-5-8-12)28-20(32)13-11-27-14-9-6-10-26-16(14)18(13)31/h3-11,15,17,19,23H,1-2H3,(H,27,31)(H,28,32)(H,29,33)(H,35,36)/t15-,17-,19+,23-/m1/s1
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[[(2R)-2-[(4-oxo-1H-1,5-naphthyridine-3-carbonyl)amino]-2-phenylacetyl]amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
International Nonproprietary Names Click here for help
INN number INN
4422 apalcillin
Synonyms Click here for help
PC-904 | PC904 | WY-44,417 | WY-44417
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo 1050
Other databases
CAS Registry No. 63469-19-2 (source: WHO INN record)
ChEMBL Ligand CHEMBL3306902
DrugCentral Ligand 227
GtoPdb PubChem SID 405560200
PubChem CID 6602341
Search Google for chemical match using the InChIKey XMQVYNAURODYCQ-SLFBBCNNSA-N
Search Google for chemicals with the same backbone XMQVYNAURODYCQ
Search PubMed clinical trials apalcillin
Search PubMed titles apalcillin
Search PubMed titles/abstracts apalcillin
UniChem Compound Search for chemical match using the InChIKey XMQVYNAURODYCQ-SLFBBCNNSA-N
UniChem Connectivity Search for chemical match using the InChIKey XMQVYNAURODYCQ-SLFBBCNNSA-N