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Synonyms: PC-904 | PC904 | WY-44,417 | WY-44417
Compound class: Synthetic organic
Comment: Apalcillin (PC-904) is a semisynthetic penicillin (β-lactam) derivative antibiotic [1-2]. It is highly active against Pseudomonas species. Toxicity issues meant that this compound did not progress beyond preclinical evaluation.
1. Noguchi H, Eda Y, Tobiki H, Nakagome T, Komatsu T. (1976)
PC-904, a novel broad-spectrum semisynthetic penicillin with marked antipseudomonal activity: microbiological evaluation.
Antimicrob Agents Chemother, 9 (2): 262-73. [PMID:1046355]
2. Noguchi H, Matsuhashi M, Takaoka M, Mitsuhashi S. (1978)
New antipseudomonal penicillin, PC-904: affinity to penicillin-binding proteins and inhibition of the enzyme cross-linking peptidoglycan.
Antimicrob Agents Chemother, 14 (4): 617-24. [PMID:102247]