Synonyms: PC-904 | PC904 | WY-44,417 | WY-44417
Compound class:
Synthetic organic
Comment: Apalcillin (PC-904) is a semisynthetic penicillin (β-lactam) derivative antibacterial [1-2]. It is highly active against Pseudomonas species. Toxicity issues meant that this compound did not progress beyond preclinical evaluation.
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Bioactivity Comments |
PC-904 is reported to be 35 and 100 times more active than carbenicillin against Pseudomonas aeruginosa and Klebsiella pneumoniae respectively, and its MICs against P. aeruginosa are comparable to those of gentamicin [1], |