Synonyms: example 53 [US11530206]
Compound class:
Synthetic organic
Comment: The chemical structure for inlexisertib was obtained from proposed INN list 130 (Feb. 2024), in which the compound is described as a serine/ threonine kinase inhibitor with antineoplastic potential. The structure is claimed in Deciphera Pharmaceuticals' patent US11530206 in which inhibition of ULK1 kinase is demonstrated [1]. We predicted that inlexisertib might be Deciphera's clinical lead ULK inhibitor DCC-3116, and this was confirmed at the first time disclosures session at the 2024 ACS spring meeting in New Orleans.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
|
Classification ![]() |
|
Compound class | Synthetic organic |
IUPAC Name ![]() |
4-[3-[[2-[2-ethyl-4-(4-methylpiperazin-1-yl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]propyl]-1,4-oxazepan-5-one |
International Nonproprietary Names ![]() |
|
INN number | INN |
13005 | inlexisertib |
Synonyms ![]() |
example 53 [US11530206] |
Database Links ![]() |
|
CAS Registry No. | 2543673-19-2 (source: WHO INN record) |
GtoPdb PubChem SID | 491299991 |
PubChem CID | 155269708 |
Search Google for chemical match using the InChIKey | CNBTYICEJGEABG-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | CNBTYICEJGEABG |
Search PubMed clinical trials | inlexisertib |
Search PubMed titles | inlexisertib |
Search PubMed titles/abstracts | inlexisertib |
UniChem Compound Search for chemical match using the InChIKey | CNBTYICEJGEABG-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | CNBTYICEJGEABG-UHFFFAOYSA-N |