ChEMBL ligand: CHEMBL499876
GPR55/G-protein coupled receptor 55 in Human [ChEMBL: CHEMBL1075322] [GtoPdb: 109] [UniProtKB: Q9Y2T6] There should be some charts here, you may need to enable JavaScript!
GPR18/N-arachidonyl glycine receptor in Human [ChEMBL: CHEMBL2384898] [GtoPdb: 89] [UniProtKB: Q14330] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
GPR55/G-protein coupled receptor 55 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075322] [GtoPdb: 109] [UniProtKB: Q9Y2T6]
ChEMBL	Antagonist activity at Prolink1-tagged human GPR55 receptor expressed in CHO cells assessed as inhibition of lysophosphatidylinositol-induced beta arrestin recruitment after 90 mins by beta-galactosidase based topcount luminescence analysis	F	5	pIC50	>10000	nM	IC50	ACS Med Chem Lett (2020) 11: 2024-2031 [PMID:33062188]
ChEMBL	Agonist activity at Prolink1-tagged human GPR55 receptor expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase based topcount luminescence analysis	B	5	pEC50	>10000	nM	EC50	ACS Med Chem Lett (2020) 11: 2024-2031 [PMID:33062188]
GtoPdb	-	-	5.71	pEC50	1944	nM	EC50	Br J Pharmacol (2007) 152: 1092-101 [PMID:17876302]
GtoPdb	-	-	8.6	pEC50	2.5	nM	EC50	Br J Pharmacol (2007) 152: 825-31 [PMID:17704827]
ChEMBL	Activation of recombinant human GPR55 expressed in HEK293 cells assessed as increase in [35S]-GTPgammaS stimulation incubated for 60 min by scintillation counting method	F	8.7	pEC50	2	nM	EC50	J Med Chem (2020) 63: 12137-12155 [PMID:32804502]
GPR18/N-arachidonyl glycine receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2384898] [GtoPdb: 89] [UniProtKB: Q14330]
ChEMBL	Antagonist activity at Prolink1-tagged human GPR18 receptor expressed in CHO cells assessed as inhibition of THC-induced beta arrestin recruitment after 90 mins by beta-galactosidase based topcount luminescence analysis	F	5	pIC50	>10000	nM	IC50	ACS Med Chem Lett (2020) 11: 2024-2031 [PMID:33062188]
ChEMBL	Agonist activity at Prolink1-tagged human GPR18 receptor expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase based topcount luminescence analysis	B	5	pEC50	>10000	nM	EC50	ACS Med Chem Lett (2020) 11: 2024-2031 [PMID:33062188]
GtoPdb	-	-	6.08	pEC50	835.7	nM	EC50	Br J Pharmacol (2012) 165: 2414-24 [PMID:21595653]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]