abnormal cannabidiol [Ligand Id: 5526] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL499876
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
GPR55/G-protein coupled receptor 55 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075322] [GtoPdb: 109] [UniProtKB: Q9Y2T6]
ChEMBL Antagonist activity at Prolink1-tagged human GPR55 receptor expressed in CHO cells assessed as inhibition of lysophosphatidylinositol-induced beta arrestin recruitment after 90 mins by beta-galactosidase based topcount luminescence analysis F 5 pIC50 >10000 nM IC50 ACS Med Chem Lett (2020) 11: 2024-2031 [PMID:33062188]
ChEMBL Agonist activity at Prolink1-tagged human GPR55 receptor expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase based topcount luminescence analysis B 5 pEC50 >10000 nM EC50 ACS Med Chem Lett (2020) 11: 2024-2031 [PMID:33062188]
GtoPdb - - 5.71 pEC50 1944 nM EC50 Br J Pharmacol (2007) 152: 1092-101 [PMID:17876302]
GtoPdb - - 8.6 pEC50 2.5 nM EC50 Br J Pharmacol (2007) 152: 825-31 [PMID:17704827]
ChEMBL Activation of recombinant human GPR55 expressed in HEK293 cells assessed as increase in [35S]-GTPgammaS stimulation incubated for 60 min by scintillation counting method F 8.7 pEC50 2 nM EC50 J Med Chem (2020) 63: 12137-12155 [PMID:32804502]
GPR18/N-arachidonyl glycine receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2384898] [GtoPdb: 89] [UniProtKB: Q14330]
ChEMBL Antagonist activity at Prolink1-tagged human GPR18 receptor expressed in CHO cells assessed as inhibition of THC-induced beta arrestin recruitment after 90 mins by beta-galactosidase based topcount luminescence analysis F 5 pIC50 >10000 nM IC50 ACS Med Chem Lett (2020) 11: 2024-2031 [PMID:33062188]
ChEMBL Agonist activity at Prolink1-tagged human GPR18 receptor expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase based topcount luminescence analysis B 5 pEC50 >10000 nM EC50 ACS Med Chem Lett (2020) 11: 2024-2031 [PMID:33062188]
GtoPdb - - 6.08 pEC50 835.7 nM EC50 Br J Pharmacol (2012) 165: 2414-24 [PMID:21595653]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]