Synonyms: CR-4056 | US8633208, 1
Compound class:
Synthetic organic
Comment: CR4056 is reported to bind imidazoline-binding sites known as imidazoline receptor I2 [2]. It was developed by Rottapharm Biotech and is being pursued as a novel analgesic for inflammatory and neuropathic pain [1,3-4]. Potential for efficacy in humans has been demonstrated in rodent models of nociceptive and neuropathic pain. To date (August 2019) clinical efficacy from a proof-of-concept study in patients with knee osteoarthritis pain has only been reported in meeting abstract form (see Rovati et al. Abstract Number: 1193, 2017 ACR/ARHP Annual Meeting). The associated trial registry number is EudraCT 2015-001136-37.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
6-imidazol-1-yl-2-phenylquinazoline |
Synonyms ![]() |
CR-4056 | US8633208, 1 |
Database Links ![]() |
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BindingDB Ligand | 113058 |
CAS Registry No. | 1004997-71-0 (source: PubChem) |
ChEMBL Ligand | CHEMBL2179398 |
GtoPdb PubChem SID | 385612213 |
PubChem CID | 24898732 |
Search Google for chemical match using the InChIKey | CSZGXYBGYFNSCO-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | CSZGXYBGYFNSCO |
UniChem Compound Search for chemical match using the InChIKey | CSZGXYBGYFNSCO-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | CSZGXYBGYFNSCO-UHFFFAOYSA-N |