compound 18 [PMID: 8426367] [Ligand Id: 2961] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL133434
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  • hydroxymethylglutaryl-CoA reductase/HMG-CoA reductase in Human [ChEMBL: CHEMBL402] [GtoPdb: 639] [UniProtKB: P04035]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CYP51A1/Cytochrome P450 51 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4981] [GtoPdb: 1374] [UniProtKB: Q64654]
ChEMBL Inhibition rat liver microsome cytochrome P450DM B 5.04 pIC50 9100 nM IC50 J Med Chem (1993) 36: 410-416 [PMID:8426367]
ChEMBL Inhibition rat liver microsome cytochrome P450DM B 5.57 pIC50 2700 nM IC50 J Med Chem (1993) 36: 410-416 [PMID:8426367]
hydroxymethylglutaryl-CoA reductase/HMG-CoA reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL402] [GtoPdb: 639] [UniProtKB: P04035]
ChEMBL Inhibition of HMG-coA Reductase enzyme in AR45 cells B 4.7 pIC50 >20000 nM IC50 J Med Chem (1993) 36: 410-416 [PMID:8426367]
GtoPdb Inhibition of HMG-CoA reductase - 6 pIC50 1000 nM IC50 J Med Chem (1993) 36: 410-6 [PMID:8426367]
ChEMBL Inhibition of HMG-coA Reductase enzyme in chinese hamster ovary cells B 6 pIC50 1000 nM IC50 J Med Chem (1993) 36: 410-416 [PMID:8426367]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]