PBIT [Ligand Id: 7026] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1336959 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Caspase 3/Caspase-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2334] [GtoPdb: 1619] [UniProtKB: P42574] | ||||||||
| ChEMBL | Inhibition of recombinant human caspase-3 using Ac-LDEVD-AMC as substrate assessed as accumulation of 7-AMC incubated for 10 mins followed by substrate addition measured for 10 mins by fluorimetric analysis | B | 6.33 | pIC50 | 465.7 | nM | IC50 | Bioorg Med Chem (2013) 21: 2960-2967 [PMID:23632366] |
| lysine demethylase 5B/Lysine-specific demethylase 5B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3774295] [GtoPdb: 2681] [UniProtKB: Q9UGL1] | ||||||||
| GtoPdb | - | - | 5.52 | pIC50 | 3000 | nM | IC50 | J Biol Chem (2013) 288: 9408-17 [PMID:23408432] |
| ChEMBL | Inhibition of KDM5B (unknown origin) | B | 5.52 | pIC50 | 3000 | nM | IC50 | Eur J Med Chem (2019) 161: 131-140 [PMID:30343192] |
| Mannose-6-phosphate isomerase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2758] [UniProtKB: P34949] | ||||||||
| ChEMBL | Inhibition of human purified phosphomannose isomerase | B | 5.28 | pIC50 | 5200 | nM | IC50 | J Med Chem (2011) 54: 3661-3668 [PMID:21539312] |
| ChEMBL | Inhibition of phosphomannose isomerase (unknown origin) | B | 5.41 | pIC50 | 3900 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 4308-4311 [PMID:25124115] |
| Phosphoethanolamine/phosphocholine phosphatase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6113] [UniProtKB: Q8TCT1] | ||||||||
| ChEMBL | Inhibition of PHOSPHO1 phosphoethanolamine activity (unknown origin) assessed as amount of inorganic phosphate release after 30 mins | B | 5.89 | pIC50 | 1300 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 4308-4311 [PMID:25124115] |
| Phosphomannomutase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1741162] [UniProtKB: O15305] | ||||||||
| ChEMBL | Inhibition of PMM2 (unknown origin) | B | 4.52 | pIC50 | >30000 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 4308-4311 [PMID:25124115] |
| ChEMBL | Inhibition of human purified PMM2 | B | 4.7 | pIC50 | >20000 | nM | IC50 | J Med Chem (2011) 54: 3661-3668 [PMID:21539312] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 staining based fluorescence assay | F | 5.78 | pIC50 | 1660 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 1291-1295 [PMID:28159413] |
| lysine demethylase 5A in Human [GtoPdb: 2680] [UniProtKB: P29375] | ||||||||
| GtoPdb | - | - | 5.22 | pIC50 | 6000 | nM | IC50 | J Biol Chem (2013) 288: 9408-17 [PMID:23408432] |
| lysine demethylase 5C in Human [GtoPdb: 2682] [UniProtKB: P41229] | ||||||||
| GtoPdb | - | - | 5.31 | pIC50 | 4900 | nM | IC50 | J Biol Chem (2013) 288: 9408-17 [PMID:23408432] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
