TAK-637 [Ligand Id: 9329] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL339486 (TAK-637) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| NK1 receptor/Neurokinin 1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL249] [GtoPdb: 360] [UniProtKB: P25103] | ||||||||
| ChEMBL | Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells) | B | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (1999) 42: 3982-3993 [PMID:10508446] |
| ChEMBL | Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells) | B | 9.35 | pIC50 | 0.45 | nM | IC50 | J Med Chem (1999) 42: 3982-3993 [PMID:10508446] |
| ChEMBL | Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting | B | 9.35 | pIC50 | 0.45 | nM | IC50 | Bioorg Med Chem (2011) 19: 5175-5182 [PMID:21807525] |
| GtoPdb | Inhibition of [125I]BH-SP binding in human IM-9 cells. | - | 9.35 | pIC50 | 0.45 | nM | IC50 | J Med Chem (1999) 42: 3982-93 [PMID:10508446] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
