diltiazem [Ligand Id: 2298] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL23 (Cardizem, Dilt-CD, Diltiazem, Diltiazem extended release, Diltzac, Ditiaz, Surazem, Tiamate, Tiazac) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CYP3A4/Cytochrome P450 3A4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL340] [GtoPdb: 1337] [UniProtKB: P08684] | ||||||||
| ChEMBL | DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin) | B | 5.74 | pIC50 | 1836.6 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Inhibitory concentration against potassium channel HERG | B | 4.76 | pIC50 | 17378.01 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 2886-2890 [PMID:15911273] |
| ChEMBL | Inhibition of human Potassium channel HERG expressed in mammalian cells | B | 4.76 | pIC50 | 17378.01 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 2773-2775 [PMID:12873512] |
| ChEMBL | Inhibition of human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel) in open state | F | 4.76 | pIC50 | 17378.01 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 1737-1741 [PMID:15745831] |
| ChEMBL | Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique | B | 4.76 | pIC50 | 17378.01 | nM | IC50 | Bioorg Med Chem (2008) 16: 6252-6260 [PMID:18448342] |
| ChEMBL | Inhibition of human ERG in MCF7 cells | B | 4.76 | pIC50 | 17378.01 | nM | IC50 | Eur J Med Chem (2009) 44: 1926-1932 [PMID:19110341] |
| ChEMBL | K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1 | F | 4.76 | pIC50 | 17300 | nM | IC50 | J Med Chem (2002) 45: 3844-3853 [PMID:12190308] |
| ChEMBL | Inhibition of hERG K channel | F | 4.76 | pIC50 | 17300 | nM | IC50 | Cardiovasc Res (2011) 91: 53-61 [PMID:21300721] |
| ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183] | ||||||||
| ChEMBL | TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 0.1 uM) in MDR1-expressing LLC-PK1 cells | F | 4.11 | pIC50 | 77700 | nM | IC50 | Eur J Pharm Sci (2002) 16: 159-165 [PMID:12128170] |
| ChEMBL | Inhibition of P-glycoprotein by Hoechst assay | B | 4.21 | pIC50 | 61659.5 | nM | IC50 | Bioorg Med Chem (2007) 15: 7470-7479 [PMID:17890094] |
| ChEMBL | Inhibition of P-glycoprotein-mediated multidrug resistance in adriamycin-resistant human A2780/ADR cells by calcein AM assay | B | 4.31 | pIC50 | 49000 | nM | IC50 | Bioorg Med Chem (2009) 17: 2524-2535 [PMID:19250834] |
| ChEMBL | Inhibition of P-glycoprotein expressed in A2780/ADR cells by calcein AM assay | B | 4.37 | pIC50 | 42657.95 | nM | IC50 | Bioorg Med Chem (2007) 15: 7470-7479 [PMID:17890094] |
| ChEMBL | Inhibition of P-gp in human adriamycin-resistant A2780 cells by Hoechst 33342 assay | B | 4.37 | pIC50 | 42657.95 | nM | IC50 | Bioorg Med Chem (2008) 16: 8224-8236 [PMID:18678495] |
| Organic cation transporter 1/Solute carrier family 22 member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245] | ||||||||
| ChEMBL | Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy | B | 4.91 | pIC50 | 12400 | nM | IC50 | J Med Chem (2008) 51: 5932-5942 [PMID:18788725] |
| Voltage-dependent L-type calcium channel subunit alpha-1C in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366456] [UniProtKB: O35505] | ||||||||
| ChEMBL | Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytes | F | 4.13 | pIC50 | 74000 | nM | IC50 | J Appl Toxicol (2012) 32: 858-866 [PMID:22761000] |
| ChEMBL | Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytes | F | 4.52 | pIC50 | 30000 | nM | IC50 | J Appl Toxicol (2012) 32: 858-866 [PMID:22761000] |
| ChEMBL | Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytes | F | 6.2 | pIC50 | 630 | nM | IC50 | J Appl Toxicol (2012) 32: 858-866 [PMID:22761000] |
| Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1940] [GtoPdb: 529] [UniProtKB: Q13936] | ||||||||
| ChEMBL | Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C subunit | F | 4.36 | pIC50 | 44000 | nM | IC50 | J Appl Toxicol (2012) 32: 858-866 [PMID:22761000] |
| Cav1.2 in Ferret [GtoPdb: 529] | ||||||||
| GtoPdb | - | - | 6.3 | pIC50 | - | - | - | J Pharmacol Exp Ther (1984) 228: 245-51 [PMID:6694106] |
| Voltage-gated L-type calcium channel alpha-1C subunit in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2830] [UniProtKB: P15381] | ||||||||
| ChEMBL | Inhibition of [3H]nitrendipine binding to calcium channels in rabbit cardiac muscle | B | 4.52 | pIC50 | 30000 | nM | IC50 | J Med Chem (1988) 31: 2221-2227 [PMID:3184128] |
| Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3762] [GtoPdb: 529] [UniProtKB: P22002] | ||||||||
| ChEMBL | Calcium antagonistic activity by measuring [3H]nitrendipine displacement from rat heart L-type [Ca2+] channel | F | 6.55 | pKi | 280 | nM | Ki | J Med Chem (1995) 38: 4393-4410 [PMID:7473567] |
| ChEMBL | Binding of [3H]nitrendipine to calcium channel in rat heart membranes was determined | B | 6 | pIC50 | >1000 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 351-354 |
| ChEMBL | In vitro inhibition of K+ induced contractions of the isolated rat aorta. | F | 7 | pIC50 | 100 | nM | IC50 | J Med Chem (1998) 41: 4309-4316 [PMID:9784106] |
| ChEMBL | Ability to inhibit [3H]nitrendipine binding to the L-type calcium channel receptor(CCR) in rat heart homogenate. | B | 7.27 | pIC50 | 54 | nM | IC50 | J Med Chem (1996) 39: 2922-2938 [PMID:8709127] |
| Cav1.3 in Mouse [GtoPdb: 530] [UniProtKB: Q99246] | ||||||||
| GtoPdb | - | - | 3.5 | pIC50 | - | - | - | Eur J Pharmacol (2007) 573: 39-48 [PMID:17651721] |
| Cav1.3/Voltage-gated L-type calcium channel alpha-1D subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4132] [GtoPdb: 530] [UniProtKB: P27732] | ||||||||
| ChEMBL | Inhibition of [3H]nitrendipine binding to L-type [Ca2+] channel in rat cortex homogenate, activity expressed as pIC50 | B | 7.34 | pIC50 | 45.71 | nM | IC50 | J Med Chem (1997) 40: 125-131 [PMID:9016337] |
| Cav1.1/Voltage-gated L-type calcium channel alpha-1S subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3805] [GtoPdb: 528] [UniProtKB: Q13698] | ||||||||
| ChEMBL | Displacement of [3H]diltiazem from L-type calcium channel of guinea pig striated muscle | B | 6.42 | pKi | 380 | nM | Ki | Bioorg Med Chem Lett (1993) 3: 2797-2800 |
| Cav1.1 in Rabbit [GtoPdb: 528] | ||||||||
| GtoPdb | - | - | 4.2 | pIC50 | 63096 | nM | IC50 | J Pharmacol Exp Ther (1986) 236: 403-7 [PMID:2418195] |
| 5-HT3A in Human [GtoPdb: 379] | ||||||||
| GtoPdb | - | - | 4.68 | pIC50 | 21000 | nM | IC50 | Mol Pharmacol (2011) 80: 183-90 [PMID:21505038] |
| 5-HT3A in Mouse [GtoPdb: 379] | ||||||||
| GtoPdb | - | - | 5.26 | pIC50 | 5500 | nM | IC50 |
J Physiol (Lond.) (1999) 519 Pt 3: 713-22 [PMID:10457085]; Biol Pharm Bull (2009) 32: 861-7 [PMID:19420755] |
| Cav1.4 in Mouse [GtoPdb: 531] [UniProtKB: Q9JIS7] | ||||||||
| GtoPdb | - | - | 4 | pIC50 | - | - | - | Invest Ophthalmol Vis Sci (2004) 45: 708-13 [PMID:14744918] |
| Kv1.1 in Mouse [GtoPdb: 538] [UniProtKB: P16388] | ||||||||
| GtoPdb | - | - | 3.8 | pIC50 | - | - | - | Mol Pharmacol (1994) 45: 1227-34 [PMID:7517498] |
| Kv1.2 in Rat [GtoPdb: 539] [UniProtKB: P63142] | ||||||||
| GtoPdb | - | - | 3.7 | pKd | 187000 | nM | Kd | Mol Pharmacol (1994) 45: 1227-34 [PMID:7517498] |
| Kv1.5 in Human [GtoPdb: 542] [UniProtKB: P22460] | ||||||||
| GtoPdb | - | - | 3.9 | pKd | 115000 | nM | Kd | Mol Pharmacol (1994) 45: 1227-34 [PMID:7517498] |
| Kv1.7 in Mouse [GtoPdb: 544] [UniProtKB: Q17ST2] | ||||||||
| GtoPdb | - | - | 4.2 | pIC50 | - | - | - | J Biol Chem (1998) 273: 5851-7 [PMID:9488722] |
| Kv3.1 in Mouse [GtoPdb: 548] [UniProtKB: P15388] | ||||||||
| GtoPdb | - | - | 4 | pIC50 | - | - | - | Mol Pharmacol (1994) 45: 1227-34 [PMID:7517498] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
