acipimox [Ligand Id: 1596] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL345714 (Acipimox, NSC-759818, Olbetam)
  • HCA2 receptor/Hydroxycarboxylic acid receptor 2 in Human [ChEMBL: CHEMBL3785] [GtoPdb: 312] [UniProtKB: Q8TDS4]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
HCA2 receptor/Hydroxycarboxylic acid receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3785] [GtoPdb: 312] [UniProtKB: Q8TDS4]
ChEMBL Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation F 5.28 pEC50 5300 nM EC50 J. Med. Chem. (2007) 50: 1445-1448 [PMID:17358052]
GtoPdb - - 5.6 pEC50 2510 nM EC50 J Biol Chem (2003) 278: 9869-74 [PMID:12522134];
Biochem Biophys Res Commun (2003) 303: 364-9 [PMID:12646212]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]