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ChEMBL ligand: CHEMBL345714 (Acipimox, NSC-759818, Olbetam) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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HCA2 receptor/Hydroxycarboxylic acid receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3785] [GtoPdb: 312] [UniProtKB: Q8TDS4] | ||||||||
ChEMBL | Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation | F | 5.28 | pEC50 | 5300 | nM | EC50 | J. Med. Chem. (2007) 50: 1445-1448 [PMID:17358052] |
GtoPdb | - | - | 5.6 | pEC50 | 2510 | nM | EC50 |
J Biol Chem (2003) 278: 9869-74 [PMID:12522134]; Biochem Biophys Res Commun (2003) 303: 364-9 [PMID:12646212] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]