aloin [Ligand Id: 12498] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL497001 (Alloin, Aloin, Aloin A, Aloins, Aloinum, Barbaloin) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Arachidonate 5-lipoxygenase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2980] [UniProtKB: Q9BEG3] | ||||||||
| ChEMBL | 5-LO inhibitory activity was determined by inhibition of LTB4 biosynthesis in bovine polymorphonuclear leukocytes (PMNL) | F | 4.52 | pIC50 | >30000 | nM | IC50 | J Med Chem (1997) 40: 3773-3780 [PMID:9371243] |
| epoxide hydrolase 2/Epoxide hydratase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2409] [GtoPdb: 2970] [UniProtKB: P34913] | ||||||||
| ChEMBL | Mixed-type inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 30 mins by Dixon plot analysis | B | 4.24 | pKi | 57300 | nM | Ki | Bioorg Med Chem (2015) 23: 6659-6665 [PMID:26372074] |
| ChEMBL | Inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 1 hr by fluorescence photometric analysis | B | 4.43 | pIC50 | 37400 | nM | IC50 | Bioorg Med Chem (2015) 23: 6659-6665 [PMID:26372074] |
| P2Y12 receptor/Purinergic receptor P2Y12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2001] [GtoPdb: 328] [UniProtKB: Q9H244] | ||||||||
| ChEMBL | Displacement of [3H]PSB0413 from human platelet P2Y12 receptor | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2009) 52: 3784-3793 [PMID:19463000] |
| TAS2R43 in Human [GtoPdb: 678] [UniProtKB: P59537] | ||||||||
| GtoPdb | - | - | 5.92 | pEC50 | 1200 | nM | EC50 | Curr Biol (2007) 17: 1403-8 [PMID:17702579] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
