aloin [Ligand Id: 12498] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL497001 (Alloin, Aloin, Aloin A, Aloins, Aloinum, Barbaloin)
  • Arachidonate 5-lipoxygenase in Bovine [ChEMBL: CHEMBL2980] [UniProtKB: Q9BEG3]
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  • epoxide hydrolase 2/Epoxide hydratase in Human [ChEMBL: CHEMBL2409] [GtoPdb: 2970] [UniProtKB: P34913]
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  • P2Y12 receptor/Purinergic receptor P2Y12 in Human [ChEMBL: CHEMBL2001] [GtoPdb: 328] [UniProtKB: Q9H244]
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  • TAS2R43 in Human [GtoPdb: 678] [UniProtKB: P59537]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Arachidonate 5-lipoxygenase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2980] [UniProtKB: Q9BEG3]
ChEMBL 5-LO inhibitory activity was determined by inhibition of LTB4 biosynthesis in bovine polymorphonuclear leukocytes (PMNL) F 4.52 pIC50 >30000 nM IC50 J Med Chem (1997) 40: 3773-3780 [PMID:9371243]
epoxide hydrolase 2/Epoxide hydratase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2409] [GtoPdb: 2970] [UniProtKB: P34913]
ChEMBL Mixed-type inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 30 mins by Dixon plot analysis B 4.24 pKi 57300 nM Ki Bioorg Med Chem (2015) 23: 6659-6665 [PMID:26372074]
ChEMBL Inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 1 hr by fluorescence photometric analysis B 4.43 pIC50 37400 nM IC50 Bioorg Med Chem (2015) 23: 6659-6665 [PMID:26372074]
P2Y12 receptor/Purinergic receptor P2Y12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2001] [GtoPdb: 328] [UniProtKB: Q9H244]
ChEMBL Displacement of [3H]PSB0413 from human platelet P2Y12 receptor B 5 pKi >10000 nM Ki J Med Chem (2009) 52: 3784-3793 [PMID:19463000]
TAS2R43 in Human [GtoPdb: 678] [UniProtKB: P59537]
GtoPdb - - 5.92 pEC50 1200 nM EC50 Curr Biol (2007) 17: 1403-8 [PMID:17702579]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]