aloin [Ligand Id: 12498] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL497001 (Alloin, Aloin, Aloin A, Aloins, Aloinum, Barbaloin) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Arachidonate 5-lipoxygenase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2980] [UniProtKB: Q9BEG3] | ||||||||
| ChEMBL | 5-LO inhibitory activity was determined by inhibition of LTB4 biosynthesis in bovine polymorphonuclear leukocytes (PMNL) | F | 4.52 | pIC50 | >30000 | nM | IC50 | J Med Chem (1997) 40: 3773-3780 [PMID:9371243] |
| epoxide hydrolase 2/Epoxide hydratase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2409] [GtoPdb: 2970] [UniProtKB: P34913] | ||||||||
| ChEMBL | Mixed-type inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 30 mins by Dixon plot analysis | B | 4.24 | pKi | 57300 | nM | Ki | Bioorg Med Chem (2015) 23: 6659-6665 [PMID:26372074] |
| ChEMBL | Inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 1 hr by fluorescence photometric analysis | B | 4.43 | pIC50 | 37400 | nM | IC50 | Bioorg Med Chem (2015) 23: 6659-6665 [PMID:26372074] |
| P2Y12 receptor/Purinergic receptor P2Y12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2001] [GtoPdb: 328] [UniProtKB: Q9H244] | ||||||||
| ChEMBL | Displacement of [3H]PSB0413 from human platelet P2Y12 receptor | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2009) 52: 3784-3793 [PMID:19463000] |
| TAS2R43 in Human [GtoPdb: 678] [UniProtKB: P59537] | ||||||||
| GtoPdb | - | - | 5.92 | pEC50 | 1200 | nM | EC50 | Curr Biol (2007) 17: 1403-8 [PMID:17702579] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
