ChEMBL ligand: CHEMBL1229 (GS-4071 ETHYL ESTER, GS 4104, GS-4104, GS4104, Oseltamivir, Oseltamivir Carboxylate, RO 640796, RO-64-0796, RO-640796, RO64-0796)
Neuraminidase in Influenza A virus (A/Puerto Rico/8/1934(H1N1)) [ChEMBL: CHEMBL2051] [UniProtKB: P03468] Neuraminidase in Influenza A virus [ChEMBL: CHEMBL1667683] [UniProtKB: Q6Q793] Neuraminidase in Influenza A virus [ChEMBL: CHEMBL1667685] [UniProtKB: Q2LFS1] Neuraminidase in Influenza A virus (strain A/USSR/90/1977 H1N1) [ChEMBL: CHEMBL3559643] [UniProtKB: P03469] Neuraminidase in Influenza A virus [ChEMBL: CHEMBL6135] [UniProtKB: B4URF0] Neuraminidase in Influenza A virus (A/Aichi/2/1968(H3N2)) [ChEMBL: CHEMBL1287607] [UniProtKB: Q75VQ4] Neuraminidase in Influenza A virus [ChEMBL: CHEMBL1667684] [UniProtKB: A5Z252] Neuraminidase in Influenza B virus (strain B/Lee/1940) [ChEMBL: CHEMBL3377] [UniProtKB: P03474] Neuraminidase in Influenza A virus [ChEMBL: CHEMBL1667686] [UniProtKB: C4LRQ6] There should be some charts here, you may need to enable JavaScript!
Sialidase in Clostridium perfringens [ChEMBL: CHEMBL5189] [UniProtKB: P10481] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Neuraminidase in Influenza A virus (A/Puerto Rico/8/1934(H1N1)) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2051] [UniProtKB: P03468]
ChEMBL	Inhibition of neuraminidase in influenza A virus (A/Puerto Rico/8/1934(H1N1)) pre-incubated for 30 mins before NA-Star substrate addition for 30 mins by luminescence based assay	B	4.92	pKi	12100	nM	Ki	Bioorg Med Chem (2017) 25: 5185-5193 [PMID:28958846]
ChEMBL	Inhibition of Influenza A virus A/California/04/2009(H1N1) neuraminidase H274Y mutant using MUNANA as substrate preincubated for 5 to 15 mins followed by substrate addition measured after 30 mins by fluorescence assay	B	5.39	pIC50	4071	nM	IC50	Eur J Med Chem (2017) 141: 648-656 [PMID:29107426]
ChEMBL	Inhibition of Influenza A virus (A/Anhui/1/2005(H5N1)) neuraminidase expressed by HEK293 cells incubated for 1 hr using 4-MU-NANA substrate by spectrofluorometric assay	B	5.59	pIC50	2600	nM	IC50	Bioorg Med Chem (2019) 27: 3846-3852 [PMID:31324565]
ChEMBL	Inhibition of neuraminidase activity in Influenza A virus (A/PR/8/34 (H1N1)) infected in MDCK cells using 4-MU-NANA as substrate pretreated for 30 mins followed by substrate addition measured after 2 hrs by fluorescence assay	B	7.11	pIC50	77.6	nM	IC50	J Nat Prod (2017) 80: 2818-2824 [PMID:28984452]
ChEMBL	Inhibition of Influenza A virus (A/California/04/2009 (H1N1) neuraminidase expressed by HEK293 cells incubated for 1 hr using 4-MU-NANA substrate by spectrofluorometric assay	B	7.3	pIC50	50	nM	IC50	Bioorg Med Chem (2019) 27: 3846-3852 [PMID:31324565]
ChEMBL	Inhibition of human Influenza A virus A/PR/8/34(H1N1) neuraminidase by fluorometric method using 4MU-NeuAc substrate	B	8.15	pIC50	7.09	nM	IC50	Antimicrob Agents Chemother (2008) 52: 3484-3491 [PMID:18694948]
ChEMBL	Inhibitory activity against influenza A neuraminidase	B	9	pIC50	<1	nM	IC50	J Med Chem (2001) 44: 4379-4392 [PMID:11728184]
Neuraminidase in Influenza A virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1667683] [UniProtKB: Q6Q793]
ChEMBL	Inhibition of Influenza A virus (A/Thailand/1(KAN-1)/2004(H5N1)) neuraminidase by by Michaelis-Menten equation analysis	B	10	pKi	0.1	nM	Ki	Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520]
ChEMBL	Inhibition of Influenza A virus (A/Thailand/1(KAN-1)/2004(H5N1)) neuraminidase by fluorometric assay	B	9.52	pIC50	0.3	nM	IC50	Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520]
ChEMBL	Inhibition of Influenza A virus (A/Thailand/1(KAN-1)/2004(H5N1)) neuraminidase isolated from virus-infected BALB/c mouse by fluorometric assay	B	9.7	pIC50	0.2	nM	IC50	Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520]
Neuraminidase in Influenza A virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1667685] [UniProtKB: Q2LFS1]
ChEMBL	Inhibition of Influenza A virus (A/chicken/Yogjakarta/BBVet-IX/2004(H5N1)) neuraminidase by Michaelis-Menten equation analysis	B	8.31	pKi	4.9	nM	Ki	Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520]
ChEMBL	Inhibition of Influenza A virus (A/chicken/Yogjakarta/BBVet-IX/2004(H5N1)) neuraminidase by fluorometric assay	B	8.31	pIC50	4.9	nM	IC50	Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520]
ChEMBL	Inhibition of Influenza A virus (A/chicken/Yogjakarta/BBVet-IX/2004(H5N1)) neuraminidase isolated from virus-infected BALB/c mouse by fluorometric assay	B	8.43	pIC50	3.7	nM	IC50	Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520]
Neuraminidase in Influenza A virus (strain A/USSR/90/1977 H1N1) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3559643] [UniProtKB: P03469]
ChEMBL	Inhibition of Influenza A virus H5N1 neuraminidase using 4-methylumbelliferyl-alpha-D-Nacetylneuraminic acid sodium salt hydrate as substrate by fluorometry	B	4.05	pIC50	88200	nM	IC50	Bioorg Med Chem (2014) 22: 6047-6052 [PMID:25277281]
ChEMBL	Inhibition of recombinant Influenza A virus H1N1 neuraminidase using 4-methylumbelliferyl-alpha-D-Nacetylneuraminic acid sodium salt hydrate as substrate by fluorometry	B	4.69	pIC50	20500	nM	IC50	Bioorg Med Chem (2014) 22: 6047-6052 [PMID:25277281]
ChEMBL	Inhibition of influenza A virus (A/California/07/2009(H1N1)) pdm09 neuraminidase using MUNANA substrate pre-incubated for 30 mins before substrate addition by fluorometric assay	B	8.59	pIC50	2.57	nM	IC50	Bioorg Med Chem Lett (2014) 24: 4312-4317 [PMID:25096296]
ChEMBL	Inhibition of influenza A virus (A/Perth/16/2009(H3N2)) neuraminidase using MUNANA substrate pre-incubated for 30 mins before substrate addition by fluorometric assay	B	8.86	pIC50	1.39	nM	IC50	Bioorg Med Chem Lett (2014) 24: 4312-4317 [PMID:25096296]
Neuraminidase in Influenza A virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6135] [UniProtKB: B4URF0]
ChEMBL	Inhibition of Influenza A virus (A/whooper swan/Mongolia/1/2009(H5N1)) neuraminidase by Michaelis-Menten equation analysis	B	9.05	pKi	0.9	nM	Ki	Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520]
ChEMBL	Inhibition of influenza A/N1/PR/8/34 neuraminidase	B	10	pKi	0.1	nM	Ki	Bioorg Med Chem Lett (2008) 18: 1692-1695 [PMID:18242993]
ChEMBL	Inhibition of Influenza A virus (A/Sw/Kor/CAH1/04 (H1N1) KCTC 11165BP neuraminidase after 30 mins by spectrofluorimetric analysis	B	4.02	pIC50	95220	nM	IC50	J Nat Prod (2010) 73: 1636-1642 [PMID:20886838]
ChEMBL	Inhibition of Influenza A virus H1N1 neuraminidase H275Y mutant	B	4.1	pIC50	79940	nM	IC50	Bioorg Med Chem (2015) 23: 7777-7784 [PMID:26643220]
ChEMBL	Inhibition of Influenza A virus (A/California/08/2009(H1N1)) wild type neuraminidase expressed in human 293T cells after 30 mins by spectrofluorimetric analysis	B	4.29	pIC50	51540	nM	IC50	J Nat Prod (2010) 73: 1636-1642 [PMID:20886838]
ChEMBL	Inhibition of oseltamivir-resistant Influenza A virus (A/California/08/2009(H1N1)) neuraminidase H274Y mutant expressed in human 293T cells after 30 mins by spectrofluorimetric analysis	B	4.91	pIC50	12290	nM	IC50	J Nat Prod (2010) 73: 1636-1642 [PMID:20886838]
ChEMBL	Inhibition of Influenza A virus (A/Kawasaki/IMS22A-954/2003(H3N2)) neuraminidase R292K mutant after 30 mins by fluorescence analysis	B	4.98	pIC50	10400	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus (A/chicken/Korea/01310/2001 (H9N2)) neuraminidase after 30 mins by spectrofluorimetric analysis	B	4.99	pIC50	10340	nM	IC50	J Nat Prod (2010) 73: 1636-1642 [PMID:20886838]
ChEMBL	Inhibition of Influenza A virus (A/Anhui/1/2013 (H7N9) neuraminidase expressed by HEK293 cells incubated for 1 hr using 4-MU-NANA substrate by spectrofluorometric assay	B	5.02	pIC50	9600	nM	IC50	Bioorg Med Chem (2019) 27: 3846-3852 [PMID:31324565]
ChEMBL	Inhibition of oseltamivir-resistant Influenza A virus H3N2 neuraminidase E119V mutant	B	5.38	pIC50	4190	nM	IC50	Bioorg Med Chem (2015) 23: 7777-7784 [PMID:26643220]
ChEMBL	Inhibition of Influenza A virus type A H3N2 neuraminidase	B	5.49	pIC50	3235.94	nM	IC50	Bioorg Med Chem (2007) 15: 2749-2758 [PMID:17287121]
ChEMBL	Inhibition of Influenza A virus type A H3N2 neuraminidase	B	5.97	pIC50	1060	nM	IC50	Bioorg Med Chem (2007) 15: 2749-2758 [PMID:17287121]
ChEMBL	Inhibition of Influenza A virus (A/Yokohama/67/2006(clone 11)(H1N1)) neuraminidase H274Y mutant after 30 mins by fluorescence analysis	B	6.12	pIC50	755	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus H1N1 wild type neuraminidase	B	6.68	pIC50	210	nM	IC50	Bioorg Med Chem (2015) 23: 7777-7784 [PMID:26643220]
ChEMBL	Inhibition of oseltamivir-resistant Influenza A virus H3N2 neuraminidase	B	6.82	pIC50	150	nM	IC50	Bioorg Med Chem (2015) 23: 7777-7784 [PMID:26643220]
ChEMBL	Inhibition of Influenza A virus (A/Yokohama/IMS9A-2029/2003(H3N2)) neuraminidase E119V mutant after 30 mins by fluorescence analysis	B	6.85	pIC50	140	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus (A/Turkey/651242/2006(H5N1)) neuraminidase A119A mutant isolated from virus-infected BALB/c mouse by fluorometric assay	B	6.86	pIC50	136.9	nM	IC50	Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520]
ChEMBL	Inhibition of oseltamivir-resistant Influenza A virus H1N1 B/55/08 neuraminidase by chemiluminescence based assay	B	7.1	pIC50	80	nM	IC50	J Nat Prod (2014) 77: 563-570 [PMID:24313801]
ChEMBL	Inhibition of Influenza A virus H5N1 neuraminidase using MUNANA as substrate preincubated for 30 mins measured after 2 hrs	B	7.3	pIC50	50	nM	IC50	Bioorg Med Chem Lett (2014) 24: 636-643 [PMID:24374271]
ChEMBL	Inhibition of Influenza A virus H3N2 neuraminidase using MUNANA as substrate preincubated for 30 mins measured after 2 hrs	B	7.3	pIC50	50	nM	IC50	Bioorg Med Chem Lett (2014) 24: 636-643 [PMID:24374271]
ChEMBL	Inhibition of Influenza A virus (A/Kawasaki/MS31A-1030/2002(H3N2)) neuraminidase N294S mutant after 30 mins by fluorescence analysis	B	7.43	pIC50	37.2	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus H7N1 N1 neuraminidase expressed in baculovirus using 2'-(4-Methylumbelliferyl)-alpha-D-acetyl neuraminic acid as substrate incubated for 2 hrs prior to substrate addition measured after 5 hrs by fluorimetry	B	7.6	pIC50	24.9	nM	IC50	Bioorg Med Chem (2012) 20: 2152-2157 [PMID:22342267]
ChEMBL	Inhibition of influenza A virus neuraminidase assessed as cleavage of MUNANA substrate by fluorescence assay	B	7.7	pIC50	20	nM	IC50	Bioorg Med Chem (2011) 19: 2342-2348 [PMID:21382719]
ChEMBL	Inhibition of influenza A virus A/duck/China/QJ/01(H5N1) neuraminidase using 4-MU-NANA as substrate incubated for 5 mins prior to substrate addition measured after 30 to 60 mins by fluorescence assay	B	7.8	pIC50	16	nM	IC50	Bioorg Med Chem (2013) 21: 7715-7723 [PMID:24262883]
ChEMBL	Inhibition of Influenza A virus A/Anhui/1/2013(H7N9) neuraminidase 150 cavity at 10 uM using MUNANA as substrate preincubated for 5 to 15 mins followed by substrate addition measured after 30 mins by fluorescence assay relative to control	B	7.83	pIC50	14.8	nM	IC50	Eur J Med Chem (2017) 141: 648-656 [PMID:29107426]
ChEMBL	Inhibition of Influenza A virus H1N1 A/duck/China/QJ/01 neuraminidase N1 using 4-MU-NANA as substrate after 5 mins by fluorescence assay	B	8	pIC50	10	nM	IC50	Bioorg Med Chem Lett (2013) 23: 3556-3560 [PMID:23664211]
ChEMBL	Inhibition of Influenza A virus A/California/07/2009 (H1N1) neuraminidase using MUNANA as substrate preincubated for 30 mins measured after 2 hrs	B	8	pIC50	10	nM	IC50	Bioorg Med Chem Lett (2014) 24: 636-643 [PMID:24374271]
ChEMBL	Inhibition of Influenza A virus A/Hong Kong/8/1968 (H3N2) neuraminidase using MUNANA as substrate preincubated for 30 mins measured after 2 hrs	B	8.1	pIC50	8	nM	IC50	Bioorg Med Chem Lett (2014) 24: 636-643 [PMID:24374271]
ChEMBL	Inhibition of human influenza A virus A/DK/HK/313/4/78(H5N3) neuraminidase by fluorometric method using 4MU-NeuAc substrate	B	8.31	pIC50	4.95	nM	IC50	Antimicrob Agents Chemother (2008) 52: 3484-3491 [PMID:18694948]
ChEMBL	Inhibition of Influenza A virus (A/turkey/Ontario/6,118/1968(H8N4)) neuraminidase after 30 mins by fluorescence analysis	B	8.44	pIC50	3.65	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus (A/Wisconsin/67/2005(H3N2)) neuraminidase after 30 mins by fluorescence analysis	B	8.46	pIC50	3.44	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus (A/duck/Hokkaido/84/2002(H5N3)) neuraminidase after 30 mins by fluorescence analysis	B	8.53	pIC50	2.94	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus (A/duck/England/1/1956(H11N6)) neuraminidase after 30 mins by fluorescence analysis	B	8.55	pIC50	2.81	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus (A/Chicken/Shandong/LY/08(H9N2)) neuraminidase using 4-MU-NANA as substrate incubated for 5 mins prior to substrate addition measured after 30 to 60 mins by fluorescence assay	B	8.55	pIC50	2.8	nM	IC50	Bioorg Med Chem (2013) 21: 7715-7723 [PMID:24262883]
ChEMBL	Inhibition of Influenza A virus (A/seal/Massachusetts/1/1980(H7N7)) neuraminidase after 30 mins by fluorescence analysis	B	8.59	pIC50	2.56	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus A/California/04/2009(H1N1) neuraminidase using MUNANA as substrate preincubated for 5 to 15 mins followed by substrate addition measured after 30 mins by fluorescence assay	B	8.6	pIC50	2.5	nM	IC50	Eur J Med Chem (2017) 141: 648-656 [PMID:29107426]
ChEMBL	Inhibition of Influenza A virus (A/Puerto Rico/8/1934(H1N1)) neuraminidase after 30 mins by fluorescence analysis	B	8.62	pIC50	2.39	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus (A/Aichi/2/1968(H3N2)) neuraminidase after 30 mins by fluorescence analysis	B	8.62	pIC50	2.39	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus (A/Yokohama/67/2006(clone 1)(H1N1)) wild type neuraminidase after 30 mins by fluorescence analysis	B	8.64	pIC50	2.28	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus (A/R(duck/Mongolia/54/01-duck/Mongolia/47/01)(H5H1)) neuraminidase after 30 mins by fluorescence analysis	B	8.66	pIC50	2.17	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus (A/duck/Ukraine/1/1963(H3N8)) neuraminidase after 30 mins by fluorescence analysis	B	8.67	pIC50	2.12	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus (A/Wellington/1/2004(H3N2)) neuraminidase after 30 mins by fluorescence analysis	B	8.7	pIC50	1.99	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus (A/California/07/2004(H3N2)) neuraminidase after 30 mins by fluorescence analysis	B	8.72	pIC50	1.9	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus (A/Okinawa/42/2004(H1N1)) neuraminidase after 30 mins by fluorescence analysis	B	8.73	pIC50	1.86	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus (A/Yokohama/IMS9A-2029/2003(H3N2)) wild type neuraminidase after 30 mins by fluorescence analysis	B	8.75	pIC50	1.78	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus (A/Wyoming/03/2003(H3N2)) neuraminidase after 30 mins by fluorescence analysis	B	8.77	pIC50	1.71	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus (A/duck/Memphis/546/1974(H11N9)) neuraminidase after 30 mins by fluorescence analysis	B	8.77	pIC50	1.7	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus (A/chicken/Sandong/Li/2008(H9N2)) neuraminidase N2 using 4-MU-NANA as substrate after 5 mins by fluorescence assay	B	8.77	pIC50	1.7	nM	IC50	Bioorg Med Chem Lett (2013) 23: 3556-3560 [PMID:23664211]
ChEMBL	Inhibition of Influenza A virus (A/Kitakyushu/159/1993(H3N2)) neuraminidase after 30 mins by fluorescence analysis	B	8.8	pIC50	1.6	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Noncompetitive inhibition of recombinant influenza A virus rvH1N1 A/Bervig_Mission/1/18 neuraminidase	B	8.8	pIC50	1.59	nM	IC50	Bioorg Med Chem (2009) 17: 6816-6823 [PMID:19729316]
ChEMBL	Inhibition of Influenza A virus (A/New Caledonia/20/1999(H1N1)) neuraminidase after 30 mins by fluorescence analysis	B	8.8	pIC50	1.58	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus (A/New York/55/2004(H3N2)) neuraminidase after 30 mins by fluorescence analysis	B	8.81	pIC50	1.56	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus (A/Yamagata/32/1989(H1N1)) neuraminidase after 30 mins by fluorescence analysis	B	8.81	pIC50	1.54	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus (A/whooper swan/Mongolia/1/2009(H5N1)) neuraminidase by fluorometric assay	B	8.82	pIC50	1.5	nM	IC50	Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520]
ChEMBL	Inhibition of Influenza A virus (A/duck/Alberta/60/1976(H12N5)) neuraminidase after 30 mins by fluorescence analysis	B	8.84	pIC50	1.43	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus (A/Shiga/1/2002(H1N1)) neuraminidase after 30 mins by fluorescence analysis	B	8.87	pIC50	1.34	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus (A/Hiroshima/52/2005(H3N2)) neuraminidase after 30 mins by fluorescence analysis	B	8.88	pIC50	1.33	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus (A/Aichi/193/2004(H1N1)) neuraminidase after 30 mins by fluorescence analysis	B	8.9	pIC50	1.26	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus (A/Kawasaki/IMS22A-954/2003(H3N2)) wild type neuraminidase after 30 mins by fluorescence analysis	B	8.9	pIC50	1.25	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus (A/whooper swan/Mongolia/1/2009(H5N1)) neuraminidase isolated from virus-infected BALB/c mouse by fluorometric assay	B	8.92	pIC50	1.2	nM	IC50	Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520]
ChEMBL	Inhibition of Influenza A virus (A/Kawasaki/MS31A-1030/2002(H3N2)) wild type neuraminidase after 30 mins by fluorescence analysis	B	8.93	pIC50	1.18	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus (A/Aichi/169/2005(H1N1)) neuraminidase after 30 mins by fluorescence analysis	B	8.95	pIC50	1.12	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus (A/Saitama/78/2003(H1N1)) neuraminidase after 30 mins by fluorescence analysis	B	8.95	pIC50	1.12	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus (A/Yamagata/1/2002(H3N2)) neuraminidase after 30 mins by fluorescence analysis	B	8.96	pIC50	1.09	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus (A/Yamagata/3/2002(H1N1)) neuraminidase after 30 mins by fluorescence analysis	B	8.97	pIC50	1.08	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus (A/Osaka/56/2004(H3N2)) neuraminidase after 30 mins by fluorescence analysis	B	8.97	pIC50	1.08	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of influenza A virus neuraminidase	B	9	pIC50	1	nM	IC50	Bioorg Med Chem Lett (2011) 21: 7137-7141 [PMID:22001088]
ChEMBL	Inhibition of Influenza A virus (A/Yamagata/2/2002(H3N2)) neuraminidase after 30 mins by fluorescence analysis	B	9.01	pIC50	0.98	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus (A/Singapore/1/1957(H2N2)) neuraminidase after 30 mins by fluorescence analysis	B	9.03	pIC50	0.93	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus (A/Tokushima/1/2005(H3N2)) neuraminidase after 30 mins by fluorescence analysis	B	9.03	pIC50	0.93	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus (A/Saitama/07/2006(H3N2)) neuraminidase after 30 mins by fluorescence analysis	B	9.05	pIC50	0.89	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A H1N1 virus neuraminidase after 1 hr by spectrofluorimetry using 2-(4-meythylumbelliferyl)-alpha-D-acetylneuramic acid as substrate	B	9.06	pIC50	0.87	nM	IC50	Eur J Med Chem (2014) 83: 466-473 [PMID:24992074]
ChEMBL	Inhibition of Influenza A virus (A/Yamagata/83/2006(H1N1)) neuraminidase after 30 mins by fluorescence analysis	B	9.11	pIC50	0.79	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus (A/Saitama/80/2003(H3N2)) neuraminidase after 30 mins by fluorescence analysis	B	9.15	pIC50	0.71	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus (A/Shiga/5/2002(H3N2)) neuraminidase after 30 mins by fluorescence analysis	B	9.15	pIC50	0.71	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus (A/Yamagata/57/2002(H1N1)) neuraminidase after 30 mins by fluorescence analysis	B	9.18	pIC50	0.66	nM	IC50	Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520]
ChEMBL	Inhibition of Influenza A virus J/8178/09 neuraminidase by chemiluminescence based assay	B	9.3	pIC50	0.5	nM	IC50	J Nat Prod (2014) 77: 563-570 [PMID:24313801]
ChEMBL	Inhibition of Influenza A virus (A/Puerto Rico/8/1934(H1N1)) neuraminidase by chemiluminescence based assay	B	9.52	pIC50	0.3	nM	IC50	J Nat Prod (2014) 77: 563-570 [PMID:24313801]
ChEMBL	Inhibition of Influenza A virus H7N3 N3 neuraminidase expressed in baculovirus using 2'-(4-Methylumbelliferyl)-alpha-D-acetyl neuraminic acid as substrate incubated for 2 hrs prior to substrate addition measured after 5 hrs by fluorimetry	B	9.7	pIC50	0.2	nM	IC50	Bioorg Med Chem (2012) 20: 2152-2157 [PMID:22342267]
ChEMBL	Inhibition of Influenza A virus (A/Hong Kong/1/1968(H3N2)) neuraminidase by chemiluminescence based assay	B	9.7	pIC50	0.2	nM	IC50	J Nat Prod (2014) 77: 563-570 [PMID:24313801]
ChEMBL	Inhibition of Influenza Virus A/Belzig/2/01 (H1N1) neuraminidase	B	9.7	pIC50	0.2	nM	IC50	J Med Chem (2010) 53: 778-786 [PMID:20014777]
ChEMBL	Inhibition of Influenza Virus A/Brest/IDT7490/08 (H1N1) neuraminidase	B	9.72	pIC50	0.19	nM	IC50	J Med Chem (2010) 53: 778-786 [PMID:20014777]
ChEMBL	Inhibition of Influenza Virus A/Potsdam/15/81 (H1N1) neuraminidase	B	9.8	pIC50	0.16	nM	IC50	J Med Chem (2010) 53: 778-786 [PMID:20014777]
ChEMBL	Inhibition of Influenza Virus A/Horneburg/IDT7489/08 (H1N1) neuraminidase	B	10.22	pIC50	0.06	nM	IC50	J Med Chem (2010) 53: 778-786 [PMID:20014777]
Neuraminidase in Influenza A virus (A/Aichi/2/1968(H3N2)) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1287607] [UniProtKB: Q75VQ4]
ChEMBL	Inhibition of human influenza A virus A/Aichi/2/1968(H3N2) neuraminidase by fluorometric method using 4MU-NeuAc substrate	B	8.81	pIC50	1.55	nM	IC50	Antimicrob Agents Chemother (2008) 52: 3484-3491 [PMID:18694948]
Neuraminidase in Influenza A virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1667684] [UniProtKB: A5Z252]
ChEMBL	Inhibition of Influenza A virus (A/Turkey/651242/2006(H5N1)) neuraminidase by Michaelis-Menten equation analysis	B	8.1	pKi	7.9	nM	Ki	Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520]
ChEMBL	Inhibition of Influenza A virus A/Anhui/1/2005(H5N1) neuraminidase using MUNANA as substrate preincubated for 5 to 15 mins followed by substrate addition measured after 30 mins by fluorescence assay	B	6.68	pIC50	210	nM	IC50	Eur J Med Chem (2017) 141: 648-656 [PMID:29107426]
ChEMBL	Inhibition of Influenza A virus (A/Turkey/651242/2006(H5N1)) neuraminidase by fluorometric assay	B	7.97	pIC50	10.8	nM	IC50	Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520]
Neuraminidase in Influenza B virus (strain B/Lee/1940) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3377] [UniProtKB: P03474]
ChEMBL	Inhibition of influenza B/Memphis/3/89 neuraminidase	B	8.96	pKi	1.1	nM	Ki	Bioorg Med Chem Lett (2008) 18: 1692-1695 [PMID:18242993]
ChEMBL	Inhibitory activity against influenza B neuraminidase	B	8.3	pIC50	5	nM	IC50	J Med Chem (2001) 44: 4379-4392 [PMID:11728184]
Neuraminidase in Influenza A virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1667686] [UniProtKB: C4LRQ6]
ChEMBL	Inhibition of Influenza A virus (A/duck/Laos/25/2006(H5N1)) neuraminidase by Michaelis-Menten equation analysis	B	8.96	pKi	1.1	nM	Ki	Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520]
ChEMBL	Inhibition of Influenza A virus A/Anhui/1/2005(H5N1) neuraminidase H274Y mutant using MUNANA as substrate preincubated for 5 to 15 mins followed by substrate addition measured after 30 mins by fluorescence assay	B	5.22	pIC50	6095	nM	IC50	Eur J Med Chem (2017) 141: 648-656 [PMID:29107426]
ChEMBL	Inhibition of Influenza A virus (A/duck/Laos/25/2006(H5N1)) neuraminidase by fluorometric assay	B	10	pIC50	0.1	nM	IC50	Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520]
ChEMBL	Inhibition of Influenza A virus (A/duck/Laos/25/2006(H5N1)) neuraminidase isolated from virus-infected BALB/c mouse by fluorometric assay	B	10	pIC50	0.1	nM	IC50	Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520]
Sialidase in Clostridium perfringens (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5189] [UniProtKB: P10481]
ChEMBL	Inhibition of Clostridium perfringenes neuraminidase activity using 4-methylumbelliferyl-1-alpha-D-N-acetylneuramic acid sodium salt hydrate as substrate by fluorescence based assay	B	4.21	pIC50	61100	nM	IC50	Bioorg Med Chem Lett (2017) 27: 5429-5435 [PMID:29141777]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]