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ChEMBL ligand: CHEMBL1229 (GS-4071 ETHYL ESTER, GS 4104, GS-4104, GS4104, Oseltamivir, Oseltamivir Carboxylate, RO 640796, RO-64-0796, RO-640796, RO64-0796) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Neuraminidase in Influenza B virus (strain B/Lee/1940) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3377] [UniProtKB: P03474] | ||||||||
ChEMBL | Inhibition of influenza B/Memphis/3/89 neuraminidase | B | 8.96 | pKi | 1.1 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 1692-1695 [PMID:18242993] |
ChEMBL | Inhibitory activity against influenza B neuraminidase | B | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (2001) 44: 4379-4392 [PMID:11728184] |
Neuraminidase in Influenza A virus (A/Puerto Rico/8/1934(H1N1)) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2051] [UniProtKB: P03468] | ||||||||
ChEMBL | Inhibition of neuraminidase in influenza A virus (A/Puerto Rico/8/1934(H1N1)) pre-incubated for 30 mins before NA-Star substrate addition for 30 mins by luminescence based assay | B | 4.92 | pKi | 12100 | nM | Ki | Bioorg Med Chem (2017) 25: 5185-5193 [PMID:28958846] |
ChEMBL | Inhibition of Influenza A virus A/California/04/2009(H1N1) neuraminidase H274Y mutant using MUNANA as substrate preincubated for 5 to 15 mins followed by substrate addition measured after 30 mins by fluorescence assay | B | 5.39 | pIC50 | 4071 | nM | IC50 | Eur J Med Chem (2017) 141: 648-656 [PMID:29107426] |
ChEMBL | Inhibition of Influenza A virus (A/Anhui/1/2005(H5N1)) neuraminidase expressed by HEK293 cells incubated for 1 hr using 4-MU-NANA substrate by spectrofluorometric assay | B | 5.59 | pIC50 | 2600 | nM | IC50 | Bioorg Med Chem (2019) 27: 3846-3852 [PMID:31324565] |
ChEMBL | Inhibition of neuraminidase activity in Influenza A virus (A/PR/8/34 (H1N1)) infected in MDCK cells using 4-MU-NANA as substrate pretreated for 30 mins followed by substrate addition measured after 2 hrs by fluorescence assay | B | 7.11 | pIC50 | 77.6 | nM | IC50 | J Nat Prod (2017) 80: 2818-2824 [PMID:28984452] |
ChEMBL | Inhibition of Influenza A virus (A/California/04/2009 (H1N1) neuraminidase expressed by HEK293 cells incubated for 1 hr using 4-MU-NANA substrate by spectrofluorometric assay | B | 7.3 | pIC50 | 50 | nM | IC50 | Bioorg Med Chem (2019) 27: 3846-3852 [PMID:31324565] |
ChEMBL | Inhibition of human Influenza A virus A/PR/8/34(H1N1) neuraminidase by fluorometric method using 4MU-NeuAc substrate | B | 8.15 | pIC50 | 7.09 | nM | IC50 | Antimicrob Agents Chemother (2008) 52: 3484-3491 [PMID:18694948] |
ChEMBL | Inhibitory activity against influenza A neuraminidase | B | 9 | pIC50 | <1 | nM | IC50 | J Med Chem (2001) 44: 4379-4392 [PMID:11728184] |
Neuraminidase in Influenza A virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1667683] [UniProtKB: Q6Q793] | ||||||||
ChEMBL | Inhibition of Influenza A virus (A/Thailand/1(KAN-1)/2004(H5N1)) neuraminidase by by Michaelis-Menten equation analysis | B | 10 | pKi | 0.1 | nM | Ki | Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520] |
ChEMBL | Inhibition of Influenza A virus (A/Thailand/1(KAN-1)/2004(H5N1)) neuraminidase by fluorometric assay | B | 9.52 | pIC50 | 0.3 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520] |
ChEMBL | Inhibition of Influenza A virus (A/Thailand/1(KAN-1)/2004(H5N1)) neuraminidase isolated from virus-infected BALB/c mouse by fluorometric assay | B | 9.7 | pIC50 | 0.2 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520] |
Neuraminidase in Influenza A virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1667685] [UniProtKB: Q2LFS1] | ||||||||
ChEMBL | Inhibition of Influenza A virus (A/chicken/Yogjakarta/BBVet-IX/2004(H5N1)) neuraminidase by Michaelis-Menten equation analysis | B | 8.31 | pKi | 4.9 | nM | Ki | Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520] |
ChEMBL | Inhibition of Influenza A virus (A/chicken/Yogjakarta/BBVet-IX/2004(H5N1)) neuraminidase by fluorometric assay | B | 8.31 | pIC50 | 4.9 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520] |
ChEMBL | Inhibition of Influenza A virus (A/chicken/Yogjakarta/BBVet-IX/2004(H5N1)) neuraminidase isolated from virus-infected BALB/c mouse by fluorometric assay | B | 8.43 | pIC50 | 3.7 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520] |
Neuraminidase in Influenza A virus (strain A/USSR/90/1977 H1N1) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3559643] [UniProtKB: P03469] | ||||||||
ChEMBL | Inhibition of Influenza A virus H5N1 neuraminidase using 4-methylumbelliferyl-alpha-D-Nacetylneuraminic acid sodium salt hydrate as substrate by fluorometry | B | 4.05 | pIC50 | 88200 | nM | IC50 | Bioorg Med Chem (2014) 22: 6047-6052 [PMID:25277281] |
ChEMBL | Inhibition of recombinant Influenza A virus H1N1 neuraminidase using 4-methylumbelliferyl-alpha-D-Nacetylneuraminic acid sodium salt hydrate as substrate by fluorometry | B | 4.69 | pIC50 | 20500 | nM | IC50 | Bioorg Med Chem (2014) 22: 6047-6052 [PMID:25277281] |
ChEMBL | Inhibition of influenza A virus (A/California/07/2009(H1N1)) pdm09 neuraminidase using MUNANA substrate pre-incubated for 30 mins before substrate addition by fluorometric assay | B | 8.59 | pIC50 | 2.57 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 4312-4317 [PMID:25096296] |
ChEMBL | Inhibition of influenza A virus (A/Perth/16/2009(H3N2)) neuraminidase using MUNANA substrate pre-incubated for 30 mins before substrate addition by fluorometric assay | B | 8.86 | pIC50 | 1.39 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 4312-4317 [PMID:25096296] |
Neuraminidase in Influenza A virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6135] [UniProtKB: B4URF0] | ||||||||
ChEMBL | Inhibition of Influenza A virus (A/whooper swan/Mongolia/1/2009(H5N1)) neuraminidase by Michaelis-Menten equation analysis | B | 9.05 | pKi | 0.9 | nM | Ki | Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520] |
ChEMBL | Inhibition of influenza A/N1/PR/8/34 neuraminidase | B | 10 | pKi | 0.1 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 1692-1695 [PMID:18242993] |
ChEMBL | Inhibition of Influenza A virus (A/Sw/Kor/CAH1/04 (H1N1) KCTC 11165BP neuraminidase after 30 mins by spectrofluorimetric analysis | B | 4.02 | pIC50 | 95220 | nM | IC50 | J Nat Prod (2010) 73: 1636-1642 [PMID:20886838] |
ChEMBL | Inhibition of Influenza A virus H1N1 neuraminidase H275Y mutant | B | 4.1 | pIC50 | 79940 | nM | IC50 | Bioorg Med Chem (2015) 23: 7777-7784 [PMID:26643220] |
ChEMBL | Inhibition of Influenza A virus (A/California/08/2009(H1N1)) wild type neuraminidase expressed in human 293T cells after 30 mins by spectrofluorimetric analysis | B | 4.29 | pIC50 | 51540 | nM | IC50 | J Nat Prod (2010) 73: 1636-1642 [PMID:20886838] |
ChEMBL | Inhibition of oseltamivir-resistant Influenza A virus (A/California/08/2009(H1N1)) neuraminidase H274Y mutant expressed in human 293T cells after 30 mins by spectrofluorimetric analysis | B | 4.91 | pIC50 | 12290 | nM | IC50 | J Nat Prod (2010) 73: 1636-1642 [PMID:20886838] |
ChEMBL | Inhibition of Influenza A virus (A/Kawasaki/IMS22A-954/2003(H3N2)) neuraminidase R292K mutant after 30 mins by fluorescence analysis | B | 4.98 | pIC50 | 10400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus (A/chicken/Korea/01310/2001 (H9N2)) neuraminidase after 30 mins by spectrofluorimetric analysis | B | 4.99 | pIC50 | 10340 | nM | IC50 | J Nat Prod (2010) 73: 1636-1642 [PMID:20886838] |
ChEMBL | Inhibition of Influenza A virus (A/Anhui/1/2013 (H7N9) neuraminidase expressed by HEK293 cells incubated for 1 hr using 4-MU-NANA substrate by spectrofluorometric assay | B | 5.02 | pIC50 | 9600 | nM | IC50 | Bioorg Med Chem (2019) 27: 3846-3852 [PMID:31324565] |
ChEMBL | Inhibition of oseltamivir-resistant Influenza A virus H3N2 neuraminidase E119V mutant | B | 5.38 | pIC50 | 4190 | nM | IC50 | Bioorg Med Chem (2015) 23: 7777-7784 [PMID:26643220] |
ChEMBL | Inhibition of Influenza A virus type A H3N2 neuraminidase | B | 5.49 | pIC50 | 3235.94 | nM | IC50 | Bioorg Med Chem (2007) 15: 2749-2758 [PMID:17287121] |
ChEMBL | Inhibition of Influenza A virus type A H3N2 neuraminidase | B | 5.97 | pIC50 | 1060 | nM | IC50 | Bioorg Med Chem (2007) 15: 2749-2758 [PMID:17287121] |
ChEMBL | Inhibition of Influenza A virus (A/Yokohama/67/2006(clone 11)(H1N1)) neuraminidase H274Y mutant after 30 mins by fluorescence analysis | B | 6.12 | pIC50 | 755 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus H1N1 wild type neuraminidase | B | 6.68 | pIC50 | 210 | nM | IC50 | Bioorg Med Chem (2015) 23: 7777-7784 [PMID:26643220] |
ChEMBL | Inhibition of oseltamivir-resistant Influenza A virus H3N2 neuraminidase | B | 6.82 | pIC50 | 150 | nM | IC50 | Bioorg Med Chem (2015) 23: 7777-7784 [PMID:26643220] |
ChEMBL | Inhibition of Influenza A virus (A/Yokohama/IMS9A-2029/2003(H3N2)) neuraminidase E119V mutant after 30 mins by fluorescence analysis | B | 6.85 | pIC50 | 140 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus (A/Turkey/651242/2006(H5N1)) neuraminidase A119A mutant isolated from virus-infected BALB/c mouse by fluorometric assay | B | 6.86 | pIC50 | 136.9 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520] |
ChEMBL | Inhibition of oseltamivir-resistant Influenza A virus H1N1 B/55/08 neuraminidase by chemiluminescence based assay | B | 7.1 | pIC50 | 80 | nM | IC50 | J Nat Prod (2014) 77: 563-570 [PMID:24313801] |
ChEMBL | Inhibition of Influenza A virus H5N1 neuraminidase using MUNANA as substrate preincubated for 30 mins measured after 2 hrs | B | 7.3 | pIC50 | 50 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 636-643 [PMID:24374271] |
ChEMBL | Inhibition of Influenza A virus H3N2 neuraminidase using MUNANA as substrate preincubated for 30 mins measured after 2 hrs | B | 7.3 | pIC50 | 50 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 636-643 [PMID:24374271] |
ChEMBL | Inhibition of Influenza A virus (A/Kawasaki/MS31A-1030/2002(H3N2)) neuraminidase N294S mutant after 30 mins by fluorescence analysis | B | 7.43 | pIC50 | 37.2 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus H7N1 N1 neuraminidase expressed in baculovirus using 2'-(4-Methylumbelliferyl)-alpha-D-acetyl neuraminic acid as substrate incubated for 2 hrs prior to substrate addition measured after 5 hrs by fluorimetry | B | 7.6 | pIC50 | 24.9 | nM | IC50 | Bioorg Med Chem (2012) 20: 2152-2157 [PMID:22342267] |
ChEMBL | Inhibition of influenza A virus neuraminidase assessed as cleavage of MUNANA substrate by fluorescence assay | B | 7.7 | pIC50 | 20 | nM | IC50 | Bioorg Med Chem (2011) 19: 2342-2348 [PMID:21382719] |
ChEMBL | Inhibition of influenza A virus A/duck/China/QJ/01(H5N1) neuraminidase using 4-MU-NANA as substrate incubated for 5 mins prior to substrate addition measured after 30 to 60 mins by fluorescence assay | B | 7.8 | pIC50 | 16 | nM | IC50 | Bioorg Med Chem (2013) 21: 7715-7723 [PMID:24262883] |
ChEMBL | Inhibition of Influenza A virus A/Anhui/1/2013(H7N9) neuraminidase 150 cavity at 10 uM using MUNANA as substrate preincubated for 5 to 15 mins followed by substrate addition measured after 30 mins by fluorescence assay relative to control | B | 7.83 | pIC50 | 14.8 | nM | IC50 | Eur J Med Chem (2017) 141: 648-656 [PMID:29107426] |
ChEMBL | Inhibition of Influenza A virus H1N1 A/duck/China/QJ/01 neuraminidase N1 using 4-MU-NANA as substrate after 5 mins by fluorescence assay | B | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3556-3560 [PMID:23664211] |
ChEMBL | Inhibition of Influenza A virus A/California/07/2009 (H1N1) neuraminidase using MUNANA as substrate preincubated for 30 mins measured after 2 hrs | B | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 636-643 [PMID:24374271] |
ChEMBL | Inhibition of Influenza A virus A/Hong Kong/8/1968 (H3N2) neuraminidase using MUNANA as substrate preincubated for 30 mins measured after 2 hrs | B | 8.1 | pIC50 | 8 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 636-643 [PMID:24374271] |
ChEMBL | Inhibition of human influenza A virus A/DK/HK/313/4/78(H5N3) neuraminidase by fluorometric method using 4MU-NeuAc substrate | B | 8.31 | pIC50 | 4.95 | nM | IC50 | Antimicrob Agents Chemother (2008) 52: 3484-3491 [PMID:18694948] |
ChEMBL | Inhibition of Influenza A virus (A/turkey/Ontario/6,118/1968(H8N4)) neuraminidase after 30 mins by fluorescence analysis | B | 8.44 | pIC50 | 3.65 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus (A/Wisconsin/67/2005(H3N2)) neuraminidase after 30 mins by fluorescence analysis | B | 8.46 | pIC50 | 3.44 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus (A/duck/Hokkaido/84/2002(H5N3)) neuraminidase after 30 mins by fluorescence analysis | B | 8.53 | pIC50 | 2.94 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus (A/duck/England/1/1956(H11N6)) neuraminidase after 30 mins by fluorescence analysis | B | 8.55 | pIC50 | 2.81 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus (A/Chicken/Shandong/LY/08(H9N2)) neuraminidase using 4-MU-NANA as substrate incubated for 5 mins prior to substrate addition measured after 30 to 60 mins by fluorescence assay | B | 8.55 | pIC50 | 2.8 | nM | IC50 | Bioorg Med Chem (2013) 21: 7715-7723 [PMID:24262883] |
ChEMBL | Inhibition of Influenza A virus (A/seal/Massachusetts/1/1980(H7N7)) neuraminidase after 30 mins by fluorescence analysis | B | 8.59 | pIC50 | 2.56 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus A/California/04/2009(H1N1) neuraminidase using MUNANA as substrate preincubated for 5 to 15 mins followed by substrate addition measured after 30 mins by fluorescence assay | B | 8.6 | pIC50 | 2.5 | nM | IC50 | Eur J Med Chem (2017) 141: 648-656 [PMID:29107426] |
ChEMBL | Inhibition of Influenza A virus (A/Puerto Rico/8/1934(H1N1)) neuraminidase after 30 mins by fluorescence analysis | B | 8.62 | pIC50 | 2.39 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus (A/Aichi/2/1968(H3N2)) neuraminidase after 30 mins by fluorescence analysis | B | 8.62 | pIC50 | 2.39 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus (A/Yokohama/67/2006(clone 1)(H1N1)) wild type neuraminidase after 30 mins by fluorescence analysis | B | 8.64 | pIC50 | 2.28 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus (A/R(duck/Mongolia/54/01-duck/Mongolia/47/01)(H5H1)) neuraminidase after 30 mins by fluorescence analysis | B | 8.66 | pIC50 | 2.17 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus (A/duck/Ukraine/1/1963(H3N8)) neuraminidase after 30 mins by fluorescence analysis | B | 8.67 | pIC50 | 2.12 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus (A/Wellington/1/2004(H3N2)) neuraminidase after 30 mins by fluorescence analysis | B | 8.7 | pIC50 | 1.99 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus (A/California/07/2004(H3N2)) neuraminidase after 30 mins by fluorescence analysis | B | 8.72 | pIC50 | 1.9 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus (A/Okinawa/42/2004(H1N1)) neuraminidase after 30 mins by fluorescence analysis | B | 8.73 | pIC50 | 1.86 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus (A/Yokohama/IMS9A-2029/2003(H3N2)) wild type neuraminidase after 30 mins by fluorescence analysis | B | 8.75 | pIC50 | 1.78 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus (A/Wyoming/03/2003(H3N2)) neuraminidase after 30 mins by fluorescence analysis | B | 8.77 | pIC50 | 1.71 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus (A/duck/Memphis/546/1974(H11N9)) neuraminidase after 30 mins by fluorescence analysis | B | 8.77 | pIC50 | 1.7 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus (A/chicken/Sandong/Li/2008(H9N2)) neuraminidase N2 using 4-MU-NANA as substrate after 5 mins by fluorescence assay | B | 8.77 | pIC50 | 1.7 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3556-3560 [PMID:23664211] |
ChEMBL | Inhibition of Influenza A virus (A/Kitakyushu/159/1993(H3N2)) neuraminidase after 30 mins by fluorescence analysis | B | 8.8 | pIC50 | 1.6 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Noncompetitive inhibition of recombinant influenza A virus rvH1N1 A/Bervig_Mission/1/18 neuraminidase | B | 8.8 | pIC50 | 1.59 | nM | IC50 | Bioorg Med Chem (2009) 17: 6816-6823 [PMID:19729316] |
ChEMBL | Inhibition of Influenza A virus (A/New Caledonia/20/1999(H1N1)) neuraminidase after 30 mins by fluorescence analysis | B | 8.8 | pIC50 | 1.58 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus (A/New York/55/2004(H3N2)) neuraminidase after 30 mins by fluorescence analysis | B | 8.81 | pIC50 | 1.56 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus (A/Yamagata/32/1989(H1N1)) neuraminidase after 30 mins by fluorescence analysis | B | 8.81 | pIC50 | 1.54 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus (A/whooper swan/Mongolia/1/2009(H5N1)) neuraminidase by fluorometric assay | B | 8.82 | pIC50 | 1.5 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520] |
ChEMBL | Inhibition of Influenza A virus (A/duck/Alberta/60/1976(H12N5)) neuraminidase after 30 mins by fluorescence analysis | B | 8.84 | pIC50 | 1.43 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus (A/Shiga/1/2002(H1N1)) neuraminidase after 30 mins by fluorescence analysis | B | 8.87 | pIC50 | 1.34 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus (A/Hiroshima/52/2005(H3N2)) neuraminidase after 30 mins by fluorescence analysis | B | 8.88 | pIC50 | 1.33 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus (A/Aichi/193/2004(H1N1)) neuraminidase after 30 mins by fluorescence analysis | B | 8.9 | pIC50 | 1.26 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus (A/Kawasaki/IMS22A-954/2003(H3N2)) wild type neuraminidase after 30 mins by fluorescence analysis | B | 8.9 | pIC50 | 1.25 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus (A/whooper swan/Mongolia/1/2009(H5N1)) neuraminidase isolated from virus-infected BALB/c mouse by fluorometric assay | B | 8.92 | pIC50 | 1.2 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520] |
ChEMBL | Inhibition of Influenza A virus (A/Kawasaki/MS31A-1030/2002(H3N2)) wild type neuraminidase after 30 mins by fluorescence analysis | B | 8.93 | pIC50 | 1.18 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus (A/Aichi/169/2005(H1N1)) neuraminidase after 30 mins by fluorescence analysis | B | 8.95 | pIC50 | 1.12 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus (A/Saitama/78/2003(H1N1)) neuraminidase after 30 mins by fluorescence analysis | B | 8.95 | pIC50 | 1.12 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus (A/Yamagata/1/2002(H3N2)) neuraminidase after 30 mins by fluorescence analysis | B | 8.96 | pIC50 | 1.09 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus (A/Yamagata/3/2002(H1N1)) neuraminidase after 30 mins by fluorescence analysis | B | 8.97 | pIC50 | 1.08 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus (A/Osaka/56/2004(H3N2)) neuraminidase after 30 mins by fluorescence analysis | B | 8.97 | pIC50 | 1.08 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of influenza A virus neuraminidase | B | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 7137-7141 [PMID:22001088] |
ChEMBL | Inhibition of Influenza A virus (A/Yamagata/2/2002(H3N2)) neuraminidase after 30 mins by fluorescence analysis | B | 9.01 | pIC50 | 0.98 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus (A/Singapore/1/1957(H2N2)) neuraminidase after 30 mins by fluorescence analysis | B | 9.03 | pIC50 | 0.93 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus (A/Tokushima/1/2005(H3N2)) neuraminidase after 30 mins by fluorescence analysis | B | 9.03 | pIC50 | 0.93 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus (A/Saitama/07/2006(H3N2)) neuraminidase after 30 mins by fluorescence analysis | B | 9.05 | pIC50 | 0.89 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A H1N1 virus neuraminidase after 1 hr by spectrofluorimetry using 2-(4-meythylumbelliferyl)-alpha-D-acetylneuramic acid as substrate | B | 9.06 | pIC50 | 0.87 | nM | IC50 | Eur J Med Chem (2014) 83: 466-473 [PMID:24992074] |
ChEMBL | Inhibition of Influenza A virus (A/Yamagata/83/2006(H1N1)) neuraminidase after 30 mins by fluorescence analysis | B | 9.11 | pIC50 | 0.79 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus (A/Saitama/80/2003(H3N2)) neuraminidase after 30 mins by fluorescence analysis | B | 9.15 | pIC50 | 0.71 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus (A/Shiga/5/2002(H3N2)) neuraminidase after 30 mins by fluorescence analysis | B | 9.15 | pIC50 | 0.71 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus (A/Yamagata/57/2002(H1N1)) neuraminidase after 30 mins by fluorescence analysis | B | 9.18 | pIC50 | 0.66 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
ChEMBL | Inhibition of Influenza A virus J/8178/09 neuraminidase by chemiluminescence based assay | B | 9.3 | pIC50 | 0.5 | nM | IC50 | J Nat Prod (2014) 77: 563-570 [PMID:24313801] |
ChEMBL | Inhibition of Influenza A virus (A/Puerto Rico/8/1934(H1N1)) neuraminidase by chemiluminescence based assay | B | 9.52 | pIC50 | 0.3 | nM | IC50 | J Nat Prod (2014) 77: 563-570 [PMID:24313801] |
ChEMBL | Inhibition of Influenza A virus H7N3 N3 neuraminidase expressed in baculovirus using 2'-(4-Methylumbelliferyl)-alpha-D-acetyl neuraminic acid as substrate incubated for 2 hrs prior to substrate addition measured after 5 hrs by fluorimetry | B | 9.7 | pIC50 | 0.2 | nM | IC50 | Bioorg Med Chem (2012) 20: 2152-2157 [PMID:22342267] |
ChEMBL | Inhibition of Influenza A virus (A/Hong Kong/1/1968(H3N2)) neuraminidase by chemiluminescence based assay | B | 9.7 | pIC50 | 0.2 | nM | IC50 | J Nat Prod (2014) 77: 563-570 [PMID:24313801] |
ChEMBL | Inhibition of Influenza Virus A/Belzig/2/01 (H1N1) neuraminidase | B | 9.7 | pIC50 | 0.2 | nM | IC50 | J Med Chem (2010) 53: 778-786 [PMID:20014777] |
ChEMBL | Inhibition of Influenza Virus A/Brest/IDT7490/08 (H1N1) neuraminidase | B | 9.72 | pIC50 | 0.19 | nM | IC50 | J Med Chem (2010) 53: 778-786 [PMID:20014777] |
ChEMBL | Inhibition of Influenza Virus A/Potsdam/15/81 (H1N1) neuraminidase | B | 9.8 | pIC50 | 0.16 | nM | IC50 | J Med Chem (2010) 53: 778-786 [PMID:20014777] |
ChEMBL | Inhibition of Influenza Virus A/Horneburg/IDT7489/08 (H1N1) neuraminidase | B | 10.22 | pIC50 | 0.06 | nM | IC50 | J Med Chem (2010) 53: 778-786 [PMID:20014777] |
Neuraminidase in Influenza A virus (A/Aichi/2/1968(H3N2)) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1287607] [UniProtKB: Q75VQ4] | ||||||||
ChEMBL | Inhibition of human influenza A virus A/Aichi/2/1968(H3N2) neuraminidase by fluorometric method using 4MU-NeuAc substrate | B | 8.81 | pIC50 | 1.55 | nM | IC50 | Antimicrob Agents Chemother (2008) 52: 3484-3491 [PMID:18694948] |
Neuraminidase in Influenza A virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1667684] [UniProtKB: A5Z252] | ||||||||
ChEMBL | Inhibition of Influenza A virus (A/Turkey/651242/2006(H5N1)) neuraminidase by Michaelis-Menten equation analysis | B | 8.1 | pKi | 7.9 | nM | Ki | Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520] |
ChEMBL | Inhibition of Influenza A virus A/Anhui/1/2005(H5N1) neuraminidase using MUNANA as substrate preincubated for 5 to 15 mins followed by substrate addition measured after 30 mins by fluorescence assay | B | 6.68 | pIC50 | 210 | nM | IC50 | Eur J Med Chem (2017) 141: 648-656 [PMID:29107426] |
ChEMBL | Inhibition of Influenza A virus (A/Turkey/651242/2006(H5N1)) neuraminidase by fluorometric assay | B | 7.97 | pIC50 | 10.8 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520] |
Neuraminidase in Influenza A virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1667686] [UniProtKB: C4LRQ6] | ||||||||
ChEMBL | Inhibition of Influenza A virus (A/duck/Laos/25/2006(H5N1)) neuraminidase by Michaelis-Menten equation analysis | B | 8.96 | pKi | 1.1 | nM | Ki | Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520] |
ChEMBL | Inhibition of Influenza A virus A/Anhui/1/2005(H5N1) neuraminidase H274Y mutant using MUNANA as substrate preincubated for 5 to 15 mins followed by substrate addition measured after 30 mins by fluorescence assay | B | 5.22 | pIC50 | 6095 | nM | IC50 | Eur J Med Chem (2017) 141: 648-656 [PMID:29107426] |
ChEMBL | Inhibition of Influenza A virus (A/duck/Laos/25/2006(H5N1)) neuraminidase by fluorometric assay | B | 10 | pIC50 | 0.1 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520] |
ChEMBL | Inhibition of Influenza A virus (A/duck/Laos/25/2006(H5N1)) neuraminidase isolated from virus-infected BALB/c mouse by fluorometric assay | B | 10 | pIC50 | 0.1 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520] |
Sialidase in Clostridium perfringens (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5189] [UniProtKB: P10481] | ||||||||
ChEMBL | Inhibition of Clostridium perfringenes neuraminidase activity using 4-methylumbelliferyl-1-alpha-D-N-acetylneuramic acid sodium salt hydrate as substrate by fluorescence based assay | B | 4.21 | pIC50 | 61100 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 5429-5435 [PMID:29141777] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]