bifikafusp alfa   Click here for help

GtoPdb Ligand ID: 9756

Synonyms: Darleukin | L19-IL2 | L19IL2
Immunopharmacology Ligand
Compound class: Antibody
Comment: Bifikafusp alfa (Darleukin) is a fusion protein of pro-inflammatory IL-2 and an L19 human mAb fragment (scFv domain) that binds the tumour microenvironment expressed fibronectin extradomain B (EDB) [1]. Structurally it is a diabody with two IL-2 units per molecule. Incorporation of the L19 binding fragment targets the drug to the tumour, improving selective site accumulation and tumour killing and at the same time reducing the effective dose required to achieve a meaningful response, and reducing the otherwise dose-limiting toxicities associated with high-dose IL-2 administration that would be required to produce the same killing effect. Darleukin is one of a growing number of so-called 'immunocytokines' entering clinical development.
Classification Click here for help
Compound class Antibody
International Nonproprietary Names Click here for help
INN number INN
10652 bifikafusp alfa
Synonyms Click here for help
Darleukin | L19-IL2 | L19IL2
Database Links Click here for help
GtoPdb PubChem SID 354702229
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