triprolidine [Ligand Id: 1228] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL855 (Actahist, Actidil, Actifed, Allerfed, Corphed, Histafed, Myfed, Myidyl, Trilitron, Triphed, Triprolidine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| H1 receptor/Histamine H1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL231] [GtoPdb: 262] [UniProtKB: P35367] | ||||||||
| ChEMBL | Displacement of [3H]pyrilamine from histamine H1 receptor | B | 8.8 | pKi | 1.6 | nM | Ki | J Nat Prod (1993) 56: 441-455 [PMID:8496700] |
| GtoPdb | - | - | 9 | pKi | 1 | nM | Ki |
Eur J Biochem (1994) 224: 489-95 [PMID:7925364]; J Pharmacol Exp Ther (2002) 302: 328-36 [PMID:12065734] |
| Histamine H1 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3943] [UniProtKB: P31389] | ||||||||
| ChEMBL | Potency against histamine H1 receptor on guinea pig ileum | B | 9.9 | pKd | 0.13 | nM | Kd | J Med Chem (1995) 38: 3351-3360 [PMID:7650688] |
| ChEMBL | Inhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 min | B | 8.78 | pKi | 1.66 | nM | Ki | J Med Chem (1995) 38: 3351-3360 [PMID:7650688] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
