macozinone [Ligand Id: 13055] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3330226 (Macozinona, Macozinone, PBTZ-169, PBTZ169) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Decaprenylphosphoryl-beta-D-ribose oxidase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3804751] [UniProtKB: P9WJF1] | ||||||||
| ChEMBL | Binding affinity to Mycobacterium tuberculosis DprE1 assessed as dissociation constant by biolayer interferometry | B | 5.77 | pKd | 1680 | nM | Kd | J Med Chem (2024) 67: 1914-1931 [PMID:38232131] |
| ChEMBL | Inhibition of recombinant Mycobacterium tuberculosis DprE1 expressed in Escherichia coli measured after 120 mins by Amplex Red/peroxidase coupled assay | B | 7.92 | pIC50 | 12 | nM | IC50 | Eur J Med Chem (2024) 264: 115976-115976 [PMID:38039794] |
| ChEMBL | Inhibition of Mycobacterium tuberculosis DprE1 expressed in Escherichia coli BL21 (DE3) cells assessed as formation of resorufin using FPR as substrate by Amplex Red hydrogen/peroxidase coupled assay | B | 8 | pIC50 | 10 | nM | IC50 | Eur J Med Chem (2020) 208: 112773-112773 [PMID:32898793] |
| ChEMBL | Inhibition of Mycobacterium tuberculosis H37Rv recombinant DprE1 expressed in Escherichia coli assessed as formation of resorufin using FPR as substrate by Amplex Red hydrogen/peroxidase coupled assay | B | 8 | pIC50 | 10 | nM | IC50 | ACS Med Chem Lett (2022) 13: 593-598 [PMID:35450361] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
