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ChEMBL ligand: CHEMBL53753 (PD-158780) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
ChEMBL | Inhibition of EGF-dependent autophosphorylation of EGF-R in A431 cells | F | 4.89 | pIC50 | 13000 | nM | IC50 | J Med Chem (1998) 41: 742-751 [PMID:9513602] |
GtoPdb | Inhibition of EGFR autophosphorylation | - | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (1997) 40: 1820-6 [PMID:9191958] |
ChEMBL | Tested for inhibition of autophosphorylation in Epidermal growth factor receptor stimulated A431 cells | F | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (1997) 40: 1820-1826 [PMID:9191958] |
ChEMBL | Inhibition of Epidermal growth factor receptor autophosphorylation in A431 human epidermoid carcinoma cells | B | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (1996) 39: 1823-1835 [PMID:8627606] |
ChEMBL | Inhibition of autophosphorylation of epidermal growth factor receptor in A431 cells in culture | F | 7.89 | pIC50 | 13 | nM | IC50 | J Med Chem (1998) 41: 742-751 [PMID:9513602] |
MAPK interacting serine/threonine kinase 1/MAP kinase-interacting serine/threonine-protein kinase MNK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4718] [GtoPdb: 2104] [UniProtKB: Q9BUB5] | ||||||||
ChEMBL | Inhibition of MNK1 | B | 5.77 | pIC50 | 1700 | nM | IC50 | J Med Chem (2010) 53: 6618-6628 [PMID:20722422] |
erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626] | ||||||||
ChEMBL | Inhibition of heregulin-dependent autophosphorylation of ErbB2 receptor in MDA-MB-453 cells | F | 4.28 | pIC50 | 52000 | nM | IC50 | J Med Chem (1998) 41: 742-751 [PMID:9513602] |
tyrosine kinase non receptor 2/Tyrosine kinase non-receptor protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4599] [GtoPdb: 2246] [UniProtKB: Q07912] | ||||||||
ChEMBL | Inhibition of ACK1 (unknown origin) | B | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (2021) 64: 16328-16348 [PMID:34735773] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]