ChEMBL ligand: CHEMBL14453
MT1 receptor/Melatonin receptor 1A in Human [ChEMBL: CHEMBL1945] [GtoPdb: 287] [UniProtKB: P48039] There should be some charts here, you may need to enable JavaScript!
MT2 receptor/Melatonin receptor 1B in Human [ChEMBL: CHEMBL1946] [GtoPdb: 288] [UniProtKB: P49286] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
MT1 receptor/Melatonin receptor 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1945] [GtoPdb: 287] [UniProtKB: P48039]
ChEMBL	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	B	8.51	pKi	3.1	nM	Ki	J Med Chem (2014) 57: 3161-3185 [PMID:24228714]
GtoPdb	-	-	9.2	pKi	-	-	-	Naunyn Schmiedebergs Arch Pharmacol (2003) 367: 553-61 [PMID:12764576]
ChEMBL	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	B	9.22	pKi	0.6	nM	Ki	J Med Chem (2003) 46: 1127-1129 [PMID:12646022]
ChEMBL	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	B	9.22	pKi	0.6	nM	Ki	Bioorg Med Chem (2010) 18: 3426-3436 [PMID:20444610]
ChEMBL	Binding affinity to MT1 receptor (unknown origin) expressed in HEK cells	B	9.22	pKi	0.6	nM	Ki	J Med Chem (2014) 57: 3161-3185 [PMID:24228714]
ChEMBL	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in HEK293 cells after 120 mins	B	9.22	pKi	0.6	nM	Ki	Medchemcomm (2015) 6: 1340-1344
ChEMBL	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	F	7.14	pEC50	73	nM	EC50	Bioorg Med Chem (2010) 18: 3426-3436 [PMID:20444610]
MT2 receptor/Melatonin receptor 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1946] [GtoPdb: 288] [UniProtKB: P49286]
ChEMBL	Displacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cells	B	6.78	pKi	167	nM	Ki	J Med Chem (2014) 57: 3161-3185 [PMID:24228714]
ChEMBL	Binding affinity to MT2 receptor (unknown origin) expressed in HEK cells	B	7.14	pKi	73.2	nM	Ki	J Med Chem (2014) 57: 3161-3185 [PMID:24228714]
ChEMBL	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in HEK293 cells after 120 mins	B	7.14	pKi	73.2	nM	Ki	Medchemcomm (2015) 6: 1340-1344
ChEMBL	Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	B	7.14	pKi	72.7	nM	Ki	J Med Chem (2003) 46: 1127-1129 [PMID:12646022]
ChEMBL	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	B	7.14	pKi	72.7	nM	Ki	Bioorg Med Chem (2010) 18: 3426-3436 [PMID:20444610]
GtoPdb	-	-	7.2	pKi	-	-	-	Naunyn Schmiedebergs Arch Pharmacol (2003) 367: 553-61 [PMID:12764576]
ChEMBL	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	F	6.39	pEC50	405	nM	EC50	Bioorg Med Chem (2010) 18: 3426-3436 [PMID:20444610]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]