Synonyms: Duvroq® | GSK-1278863 | GSK1278863 | Jesduvroq®
daprodustat is an approved drug (Japan (2020), FDA (2023))
Compound class:
Synthetic organic
Comment: Daprodustat is a compound which inhibits hypoxia inducible factor prolyl hydroxylase (HIF-PH) activity. HIF-PH inhibitors are being investigated as novel therapies for anemia, especially anemia caused by chronic kindney disease (CKD). It is hoped that HIF-PH inhibitors will provide a more effective alternative to the use of erythropoetin replacement therapy plus iron supplementation in CKD patients
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Classification | |
Compound class | Synthetic organic |
Approved drug? | Yes (Japan (2020), FDA (2023)) |
IUPAC Name |
2-[(1,3-dicyclohexyl-2,4,6-trioxo-1,3-diazinane-5-carbonyl)amino]acetic acid |
International Nonproprietary Names | |
INN number | INN |
10167 | daprodustat |
Synonyms |
Duvroq® | GSK-1278863 | GSK1278863 | Jesduvroq® |
Database Links | |
CAS Registry No. | 960539-70-2 |
DrugCentral Ligand | 5421 |
GtoPdb PubChem SID | 252166665 |
PubChem CID | 91617630 |
Search Google for chemical match using the InChIKey | RUEYEZADQJCKGV-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | RUEYEZADQJCKGV |
Search PubMed clinical trials | daprodustat |
Search PubMed titles | daprodustat |
Search PubMed titles/abstracts | daprodustat |
UniChem Compound Search for chemical match using the InChIKey | RUEYEZADQJCKGV-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | RUEYEZADQJCKGV-UHFFFAOYSA-N |