daprodustat   Click here for help

GtoPdb Ligand ID: 8455

Synonyms: Duvroq® | GSK-1278863 | GSK1278863 | Jesduvroq®
Approved drug
daprodustat is an approved drug (Japan (2020), FDA (2023))
Compound class: Synthetic organic
Comment: Daprodustat is a compound which inhibits hypoxia inducible factor prolyl hydroxylase (HIF-PH) activity. HIF-PH inhibitors are being investigated as novel therapies for anemia, especially anemia caused by chronic kindney disease (CKD). It is hoped that HIF-PH inhibitors will provide a more effective alternative to the use of erythropoetin replacement therapy plus iron supplementation in CKD patients
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 9
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 124.09
Molecular weight 393.19
XLogP 1.68
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES OC(=O)CNC(=O)C1C(=O)N(C2CCCCC2)C(=O)N(C1=O)C1CCCCC1
Isomeric SMILES OC(=O)CNC(=O)C1C(=O)N(C2CCCCC2)C(=O)N(C1=O)C1CCCCC1
InChI InChI=1S/C19H27N3O6/c23-14(24)11-20-16(25)15-17(26)21(12-7-3-1-4-8-12)19(28)22(18(15)27)13-9-5-2-6-10-13/h12-13,15H,1-11H2,(H,20,25)(H,23,24)
InChI Key RUEYEZADQJCKGV-UHFFFAOYSA-N
No information available.
Summary of Clinical Use Click here for help
Daprodustat (GSK1278863) was progressed to advanced clinical trial in both hemodialysis-dependent and non-dialysis dependent patient groups. Separate studies investigating GSK1278863's ability to reduce ischemic events in patients undergoing thoracic aortic aneurysm repair and evaluating any clinical benefit in patients with peripheral vascular disease (where tissue hypoxia is an issue) are also registered with ClinicalTrials.gov. In June 2020 daprodustat was approved in Japan as a treatment for renal anaemia [2]. FDA approval followed in 2023, to treat anemia caused by chronic kidney disease (for patients on dialysis for ≥4 months).
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Under normoxic conditions HIF-PH effects the degradation of HIF1-α subunits (using O2 as a substrate to hydroxylate proline residues in HIF-1α), resulting in minimal HIF-induced transcriptional activity. When oxygen levels are limited, HIF-1α is not directed for degradation, permittinh induction of transcription. HIF-PH inhibitors mimic this natural response to hypoxia, which stablises HIFα transcription factors thereby switching on transcription of genes associated with processes such as erythropoiesis and vasculogenesis [3]. In anemic patients HIF-PH inhibitors increase erythropoietin levels and subsequently increase red blood cell counts [1]. There are three human HIF-PHs, with gene symbols EGLN1, -2 and -3.