surufatinib   Click here for help

GtoPdb Ligand ID: 9769

Synonyms: HMPL-012 | HMPL012 | KDR-IN-1 | Sulanda® | VEGFR2 inhibitor [WO2011060746]
Approved drug
surufatinib is an approved drug (China (2020))
Compound class: Synthetic organic
Comment: Surufatinib is an oral tyrosine kinase inhibitor that selectively targets VEGFR 1, 2, and 3, FGFR1 and CSF-1R, to inhibit key angiogenic and immune pathways in solid tumours. Surufatinib's chemical structure is claimed in patent WO2011060746, and its use as a potential anti-angiogenic agent is included [1]. In this patent it is referred to as 'Compound of Formula A'.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 10
Topological polar surface area 120.62
Molecular weight 480.19
XLogP 2.96
No. Lipinski's rules broken 0
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Canonical SMILES CN(CCNS(=O)(=O)Cc1cccc(c1)Nc1nccc(n1)Oc1ccc2c(c1)cc([nH]2)C)C
Isomeric SMILES CN(CCNS(=O)(=O)Cc1cccc(c1)Nc1nccc(n1)Oc1ccc2c(c1)cc([nH]2)C)C
InChI InChI=1S/C24H28N6O3S/c1-17-13-19-15-21(7-8-22(19)27-17)33-23-9-10-25-24(29-23)28-20-6-4-5-18(14-20)16-34(31,32)26-11-12-30(2)3/h4-10,13-15,26-27H,11-12,16H2,1-3H3,(H,25,28,29)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (China (2020))
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
10349 surufatinib
Synonyms Click here for help
HMPL-012 | HMPL012 | KDR-IN-1 | Sulanda® | VEGFR2 inhibitor [WO2011060746]
Database Links Click here for help
CAS Registry No. 1308672-74-3 (source: WHO INN record)
GtoPdb PubChem SID 354702242
PubChem CID 52920501
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