DG-041 [Ligand Id: 5822] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL565591 (DG-041) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| EP1 receptor/Prostanoid EP1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1811] [GtoPdb: 340] [UniProtKB: P34995] | ||||||||
| ChEMBL | Displacement of [3H]PGE2 from human EP1 receptor after 1 hr by liquid scintillation counting | B | 4.7 | pIC50 | >20000 | nM | IC50 | J Med Chem (2010) 53: 18-36 [PMID:19957930] |
| EP2 receptor/Prostanoid EP2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1881] [GtoPdb: 341] [UniProtKB: P43116] | ||||||||
| ChEMBL | Displacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation counting | B | 5.38 | pIC50 | 4169 | nM | IC50 | J Med Chem (2010) 53: 18-36 [PMID:19957930] |
| EP3 receptor/Prostanoid EP3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3710] [GtoPdb: 342] [UniProtKB: P43115] | ||||||||
| GtoPdb | - | - | 8.41 | pKi | 3.9 | nM | Ki | Br J Pharmacol (2009) 158: 372-81 [PMID:19486006] |
| GtoPdb | - | - | 9.52 | pKi | 0.3 | nM | Ki | Am J Physiol Renal Physiol (2008) 295: F984-94 [PMID:18632791] |
| GtoPdb | - | - | 9.92 | pKi | 0.12 | nM | Ki | Am J Physiol Renal Physiol (2008) 295: F984-94 [PMID:18632791] |
| GtoPdb | - | - | 10.1 | pKi | 0.08 | nM | Ki | Am J Physiol Renal Physiol (2008) 295: F984-94 [PMID:18632791] |
| ChEMBL | Displacement of [3H]PGE2 from human EP3 receptor after 1 hr by liquid scintillation counting in presence of 10% human serum | B | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (2010) 53: 18-36 [PMID:19957930] |
| ChEMBL | Displacement of [3H]PGE2 from human EP3 receptor after 60 mins repeated washing by liquid scintillation counting | B | 8.34 | pIC50 | 4.6 | nM | IC50 | J Med Chem (2010) 53: 18-36 [PMID:19957930] |
| ChEMBL | Displacement of [3H]PGE2 from human EP3 receptor after 1 hr by liquid scintillation counting | B | 8.34 | pIC50 | 4.6 | nM | IC50 | J Med Chem (2010) 53: 18-36 [PMID:19957930] |
| ChEMBL | Displacement of [3H]PGE2 from human EP3 receptor | B | 8.34 | pIC50 | 4.6 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 6797-6800 [PMID:19836233] |
| EP3 receptor/Prostanoid EP3 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4336] [GtoPdb: 342] [UniProtKB: P30557] | ||||||||
| ChEMBL | Displacement of [3H]PGE2 from mouse EP3 receptor after 1 hr by liquid scintillation counting | B | 7.96 | pIC50 | 11 | nM | IC50 | J Med Chem (2010) 53: 18-36 [PMID:19957930] |
| EP4 receptor/Prostanoid EP4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1836] [GtoPdb: 343] [UniProtKB: P35408] | ||||||||
| ChEMBL | Displacement of [3H]PGE2 from human EP4 receptor after 1 hr by liquid scintillation counting | B | 5.09 | pIC50 | 8039 | nM | IC50 | J Med Chem (2010) 53: 18-36 [PMID:19957930] |
| IP receptor/Prostanoid IP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119] | ||||||||
| ChEMBL | Displacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation counting | B | 4.84 | pIC50 | 14414 | nM | IC50 | J Med Chem (2010) 53: 18-36 [PMID:19957930] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
